prdx-2 encodes one of two C. elegans typical 2-Cys peroxiredoxins,peroxidase enzymes that reduce hydrogen peroxide and contributeto the oxidative-stress response of multicellular organisms; loss of prdx-2 activity results in increased sensitivity to sublethal dosesof hydrogen peroxide and increased resistance to heavy metals, likely via increased expression of Phase II detoxification enzymes such as GCS-1 in a SKN-1-independent manner; in addition, loss ofprdx-2 results in decreased longevity and conditions that elevate levels of hyperoxidized PRDX-2 result in increased thermotolerance;PRDX-2 is expressed from early embryogenesis through postembryonicdevelopment, where it is detected in the intestine, gonad, and neurons;PRDX-2 appears to be a cytoplasmic protein, excluded from the nucleus;intestinal expression of PRDX-2 is necessary and sufficient for survivalin the presence of hydrogen peroxide, but cannot rescue the heavy-metalresistance and longevity phenotypes of prdx-2 mutants.
Enables thioredoxin peroxidase activity. Involved in several processes, including determination of adult lifespan; positive regulation of brood size; and response to inorganic substance. Located in cytoplasm. Expressed in body wall musculature; corpus; gonad; head; and tail. Human ortholog(s) of this gene implicated in colorectal cancer; methylmalonic aciduria and homocystinuria type cblC; and oral squamous cell carcinoma. Is an ortholog of human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2).
Gene name created from parsing 'genotype' field from CGC strain information
CGC_data_submission
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.