WormBase Tree Display for Gene: WBGene00002978
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WBGene00002978 | SMap | S_parent | Sequence | Y105E8B | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | lev-11 | Person_evidence | WBPerson368 | |||||
Sequence_name | Y105E8B.1 | ||||||||
Molecular_name (58) | |||||||||
Other_name | tmy-1 | ||||||||
Y105E8B.c | Curator_confirmed | WBPerson1983 | |||||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
CeTM | Paper_evidence (2) | ||||||||
CELE_Y105E8B.1 | Accession_evidence | NDB | BX284601 | ||||||
Public_name | lev-11 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lev | ||||||||
Reference_allele | WBVar00275207 | ||||||||
Allele (206) | |||||||||
Legacy_information | x12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal). | ||||||||
See also e1724 | |||||||||
[Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping. | |||||||||
[C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS. | |||||||||
[C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK] | |||||||||
Strain | WBStrain00002959 | ||||||||
WBStrain00033515 | |||||||||
WBStrain00033518 | |||||||||
WBStrain00033524 | |||||||||
WBStrain00040917 | |||||||||
WBStrain00040918 | |||||||||
WBStrain00004923 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (20) | |||||||||
Ortholog | WBGene00060848 | Caenorhabditis remanei | From_analysis | OMA | |||||
TreeFam | |||||||||
Inparanoid_8 | |||||||||
WBGene00038957 | Caenorhabditis briggsae | From_analysis | Hillier-set | ||||||
OrthoMCL | |||||||||
Inparanoid_8 | |||||||||
WormBase-Compara | |||||||||
WBGene00157417 | Caenorhabditis brenneri | From_analysis | OMA | ||||||
TreeFam | |||||||||
Inparanoid_8 | |||||||||
WBGene00080168 | Caenorhabditis remanei | From_analysis | OMA | ||||||
WBGene00121673 | Caenorhabditis japonica | From_analysis | TreeFam | ||||||
Inparanoid_8 | |||||||||
WormBase-Compara | |||||||||
WBGene00113939 | Pristionchus pacificus | From_analysis | Inparanoid_8 | ||||||
WBGene00268837 | Brugia malayi | From_analysis | WormBase-Compara | ||||||
CSP21.g6566 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara | ||||||
CSP26.g5884 | Caenorhabditis zanzibari | From_analysis | WormBase-Compara | ||||||
CSP28.g8286 | Caenorhabditis panamensis | From_analysis | WormBase-Compara | ||||||
CSP29.g13409 | Caenorhabditis becei | From_analysis | WormBase-Compara | ||||||
CSP31.g6003 | Caenorhabditis uteleia | From_analysis | WormBase-Compara | ||||||
CSP39.g12379 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara | ||||||
Cnig_chr_I.g3904 | Caenorhabditis nigoni | From_analysis | WormBase-Compara | ||||||
Csp11.Scaffold630.g19026 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara | ||||||
Csp5_scaffold_00354.g9973 | Caenorhabditis sinica | From_analysis | WormBase-Compara | ||||||
FL83_09174 | Caenorhabditis latens | From_analysis | WormBase-Compara | ||||||
GCK72_001496 | Caenorhabditis remanei | From_analysis | WormBase-Compara | ||||||
OTIPU.nOt.2.0.1.g05518 | Oscheius tipulae | From_analysis | WormBase-Compara | ||||||
Pan_g8532 | Panagrellus redivivus | From_analysis | WormBase-Compara | ||||||
Sp34_10004400 | Caenorhabditis inopinata | From_analysis | WormBase-Compara | ||||||
chrI_pilon.g2931 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00238002 | Onchocerca volvulus | From_analysis | WormBase-Compara | ||||||
WBGene00259763 | Strongyloides ratti | From_analysis | WormBase-Compara | ||||||
WBGene00287695 | Trichuris muris | From_analysis | WormBase-Compara | ||||||
SGD:S000005023 | Saccharomyces cerevisiae | From_analysis | OMA | ||||||
Panther | |||||||||
FB:FBgn0003721 | Drosophila melanogaster | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
Inparanoid | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
SonicParanoid | |||||||||
FB:FBgn0004117 | Drosophila melanogaster | From_analysis | EnsEMBL-Compara | ||||||
OMA | |||||||||
OrthoFinder | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
ZFIN:ZDB-GENE-990415-269 | Danio rerio | From_analysis | Hieranoid | ||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
SonicParanoid | |||||||||
ZFIN:ZDB-GENE-030131-2964 | Danio rerio | From_analysis | Hieranoid | ||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
SonicParanoid | |||||||||
ZFIN:ZDB-GENE-030826-16 | Danio rerio | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
SonicParanoid | |||||||||
ZFIN:ZDB-GENE-040426-854 | Danio rerio | From_analysis | Hieranoid | ||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
SonicParanoid | |||||||||
ZFIN:ZDB-GENE-040426-2185 | Danio rerio | From_analysis | Hieranoid | ||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
SonicParanoid | |||||||||
ZFIN:ZDB-GENE-040625-114 | Danio rerio | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
SonicParanoid | |||||||||
HGNC:12010 | Homo sapiens | From_analysis | Hieranoid | ||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
SonicParanoid | |||||||||
HGNC:12011 | Homo sapiens | From_analysis | Hieranoid | ||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
SonicParanoid | |||||||||
HGNC:12012 | Homo sapiens | From_analysis | Hieranoid | ||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
SonicParanoid | |||||||||
HGNC:12013 | Homo sapiens | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
SonicParanoid | |||||||||
MGI:98809 | Mus musculus | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
SonicParanoid | |||||||||
MGI:98810 | Mus musculus | From_analysis | Hieranoid | ||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
SonicParanoid | |||||||||
MGI:1890149 | Mus musculus | From_analysis | Hieranoid | ||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
SonicParanoid | |||||||||
MGI:2449202 | Mus musculus | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
MGI:99705 | Mus musculus | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
RGD:3898 | Rattus norvegicus | From_analysis | Hieranoid | ||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
SonicParanoid | |||||||||
RGD:3899 | Rattus norvegicus | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
OMA | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
SonicParanoid | |||||||||
RGD:621546 | Rattus norvegicus | From_analysis | EnsEMBL-Compara | ||||||
Hieranoid | |||||||||
OMA | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
PhylomeDB | |||||||||
RGD:1559479 | Rattus norvegicus | From_analysis | Hieranoid | ||||||
Inparanoid | |||||||||
OMA | |||||||||
OrthoFinder | |||||||||
OrthoInspector | |||||||||
Panther | |||||||||
SonicParanoid | |||||||||
Structured_description | Concise_description | lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line. | Paper_evidence (2) | ||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson1823 | |||||||||
WBPerson567 | |||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0111597 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | ||||
DOID:0110926 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
DOID:0110309 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
DOID:0110457 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
DOID:0110932 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | ||||||
DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
DOID:0080102 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
DOID:2218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12013) | ||||||
Molecular_info | Corresponding_CDS (19) | ||||||||
Corresponding_CDS_history | Y105E8B.1b:wp62 | ||||||||
Y105E8B.1b:wp114 | |||||||||
Y105E8B.1c:wp62 | |||||||||
Corresponding_transcript (20) | |||||||||
Other_sequence (913) | |||||||||
Associated_feature (35) | |||||||||
Experimental_info | RNAi_result | WBRNAi00065527 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00077371 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066821 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00064047 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00061185 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00077373 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00061195 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00077376 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00080639 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00073321 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00077374 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00085019 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00085020 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00028216 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00065529 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00085017 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00061192 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00065528 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00065526 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00077372 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00085016 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00055236 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00061187 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00064048 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00077375 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00061188 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00073322 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00061196 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00064046 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00061189 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00073323 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (15) | |||||||||
Drives_construct (12) | |||||||||
Construct_product | WBCnstr00010369 | ||||||||
WBCnstr00012505 | |||||||||
WBCnstr00016244 | |||||||||
WBCnstr00041176 | |||||||||
Antibody | WBAntibody00000099 | ||||||||
WBAntibody00000422 | |||||||||
WBAntibody00000423 | |||||||||
WBAntibody00000472 | |||||||||
Microarray_results (61) | |||||||||
Expression_cluster (304) | |||||||||
Interaction (175) | |||||||||
WBProcess | WBbiopr:00000006 | ||||||||
Map_info | Map | I | Position | 25.8125 | Error | 0.018971 | |||
Well_ordered | |||||||||
Positive | Positive_clone | Y105E8B | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Mapping_data | 2_point | 209 | |||||||
213 | |||||||||
214 | |||||||||
327 | |||||||||
5106 | |||||||||
6076 | |||||||||
Multi_point (11) | |||||||||
Pos_neg_data (13) | |||||||||
Reference (90) | |||||||||
Remark | Data extracted from Williams & Waterston 1994 | ||||||||
The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02 | |||||||||
Method | Gene |