WormBase Tree Display for Gene: WBGene00004980

WBGene00004980 SMap: S_parent: Sequence: B0464
  Identity: Version: 1
    Name: CGC_name: spk-1 Person_evidence: WBPerson1315
      Sequence_name: B0464.5
      Molecular_name (13)
      Other_name: srk-1
        rsk-1 Paper_evidence: WBPaper00003988
        CELE_B0464.5 Accession_evidence: NDB BX284603
      Public_name: spk-1
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:37 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: spk
    Allele (80)
    Strain: WBStrain00035941
    RNASeq_FPKM (74)
    GO_annotation (25)
    Ortholog: WBGene00055099 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00031566 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00142757 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00156596 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00164918 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00144286 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00125104 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00222077 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g4779 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g2475 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g5699 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g14104 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g3278 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g17718 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g15349 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g8994 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g6107 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g3364 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-spk-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g18399 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold630.g18400 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00405.g10878 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_07414 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_009428 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04604 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g10292 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g1228 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g14453 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g20289 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g5602 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30270100 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g8622 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00245115 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00096406 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00260356 Strongyloides ratti From_analysis: WormBase-Compara
      SGD:S000004829 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0030697 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
      FB:FBgn0025702 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
      ZFIN:ZDB-GENE-030131-2399 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-101025-2 Danio rerio From_analysis: OrthoFinder
            OrthoInspector
            PhylomeDB
      ZFIN:ZDB-GENE-070112-2292 Danio rerio From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-090312-151 Danio rerio From_analysis: OrthoFinder
            Panther
            PhylomeDB
      HGNC:11305 Homo sapiens From_analysis: Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:11306 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            PhylomeDB
            SonicParanoid
      HGNC:11402 Homo sapiens From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:106908 Mus musculus From_analysis: Inparanoid
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1201408 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            PhylomeDB
            SonicParanoid
      MGI:1891338 Mus musculus From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:727856 Rattus norvegicus From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:1305107 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            SonicParanoid
      RGD:1308272 Rattus norvegicus From_analysis: OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00001121 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002178 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002187 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002188 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003048 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003401 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003402 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004055 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004056 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004057 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004859 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00015478 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019665 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013091 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008200 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013705 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007977 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017672 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00013701 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017277 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009921 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). Paper_evidence (2)
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables protein serine/threonine kinase activity. Involved in embryo development. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including gonad and tail. Is an ortholog of human SRPK1 (SRSF protein kinase 1); SRPK2 (SRSF protein kinase 2); and SRPK3 (SRSF protein kinase 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: B0464.5a
      B0464.5b
      B0464.5c
      B0464.5d
    Corresponding_CDS_history: B0464.5a:wp123
      B0464.5c:wp119
    Corresponding_transcript: B0464.5a.1
      B0464.5a.2
      B0464.5b.1
      B0464.5c.1
      B0464.5d.1
    Other_sequence (83)
    Associated_feature (20)
  Experimental_info: RNAi_result (17)
    Expr_pattern: Chronogram621
      Expr439
      Expr1128
      Expr5076
      Expr1028333
      Expr1032478
      Expr1143250
      Expr2016060
      Expr2034296
    Drives_construct: WBCnstr00004059
      WBCnstr00035294
    Construct_product: WBCnstr00035294
    Microarray_results (50)
    Expression_cluster (119)
    Interaction (131)
    WBProcess: WBbiopr:00000014
  Map_info: Map: III Position: 0.536942 Error: 0.008194
    Positive: Positive_clone: B0464 Inferred_automatically: From sequence, transcript, pseudogene data
        T01H8
    Mapping_data: Multi_point: 5000
    Pseudo_map_position
  Reference (19)
  Remark: The srk-1 gene was merged into this gene following advice by Jonathan Hodgkin. srk-1 was connected to different sequences which may have been in error and these sequence connections have been removed from the merged gene. krb 27/02/02
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene