wee-1.3 encodes one of two C. elegans homologs of the Wee1 family of dual-specificity protein kinases (wee-1.1 encodes the second homolog; wee-1.2 is a pseudogene); in particular, WEE-1.3 is related to the membrane-associated vertebrate MYT1 kinases.
Enables cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including negative regulation of reproductive process; nematode larval development; and sexual reproduction. Acts upstream of or within nematode male tail tip morphogenesis. Located in several cellular components, including condensed chromosome; nuclear envelope; and perinuclear endoplasmic reticulum. Expressed in several structures, including germ line; intestine; oocyte; somatic cell; and spermatheca. Is an ortholog of human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1).