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WormBase Tree Display for Gene: WBGene00006434

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Name Class

WBGene00006434EvidenceCGC_data_submission
SMapS_parentSequenceF09E5
IdentityVersion2
NameCGC_nameprdx-2Paper_evidenceWBPaper00006517
Sequence_nameF09E5.15
Molecular_nameF09E5.15a
F09E5.15a.1
CE32361
F09E5.15b
CE41559
F09E5.15c
CE50863
F09E5.15b.1
F09E5.15c.1
Other_nameceprx2Paper_evidenceWBPaper00006517
tag-56CGC_data_submission
CELE_F09E5.15Accession_evidenceNDBBX284602
Public_nameprdx-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
213 Dec 2004 10:52:32WBPerson2970Name_changeCGC_nameprdx-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classprdx
Allele (20)
StrainWBStrain00035650
RNASeq_FPKM (74)
GO_annotation (29)
Contained_in_operonCEOP2172
CEOP2745
Ortholog (43)
ParalogWBGene00011110Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00021401Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionprdx-2 encodes one of two C. elegans typical 2-Cys peroxiredoxins,peroxidase enzymes that reduce hydrogen peroxide and contributeto the oxidative-stress response of multicellular organisms; loss of prdx-2 activity results in increased sensitivity to sublethal dosesof hydrogen peroxide and increased resistance to heavy metals, likely via increased expression of Phase II detoxification enzymes such as GCS-1 in a SKN-1-independent manner; in addition, loss ofprdx-2 results in decreased longevity and conditions that elevate levels of hyperoxidized PRDX-2 result in increased thermotolerance;PRDX-2 is expressed from early embryogenesis through postembryonicdevelopment, where it is detected in the intestine, gonad, and neurons;PRDX-2 appears to be a cytoplasmic protein, excluded from the nucleus;intestinal expression of PRDX-2 is necessary and sufficient for survivalin the presence of hydrogen peroxide, but cannot rescue the heavy-metalresistance and longevity phenotypes of prdx-2 mutants.Paper_evidenceWBPaper00032399
Curator_confirmedWBPerson1843
Date_last_updated10 Dec 2008 00:00:00
Automated_descriptionEnables thioredoxin peroxidase activity. Involved in several processes, including determination of adult lifespan; positive regulation of brood size; and response to inorganic substance. Located in cytoplasm. Expressed in body wall musculature; corpus; gonad; head; and tail. Human ortholog(s) of this gene implicated in colorectal cancer; methylmalonic aciduria and homocystinuria type cblC; and oral squamous cell carcinoma. Is an ortholog of human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050866Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9353)
DOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9353)
DOID:0050715Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9352)
Molecular_infoCorresponding_CDS (3)
Corresponding_CDS_historyF09E5.15:wp182
Corresponding_transcriptF09E5.15a.1
F09E5.15b.1
F09E5.15c.1
Other_sequence (484)
Associated_feature (15)
Experimental_infoRNAi_result (14)
Expr_patternExpr2948
Expr2949
Expr5699
Expr8393
Expr12198
Expr1024080
Expr1032614
Expr1148092
Expr2015087
Expr2033324
Drives_constructWBCnstr00003077
WBCnstr00011033
WBCnstr00020592
WBCnstr00034358
Construct_productWBCnstr00005484
WBCnstr00011033
WBCnstr00020592
WBCnstr00034358
AntibodyWBAntibody00000736
WBAntibody00001484
Microarray_results (20)
Expression_cluster (165)
InteractionWBInteraction000034759
WBInteraction000034899
WBInteraction000035306
WBInteraction000035309
WBInteraction000038538
WBInteraction000038790
WBInteraction000039179
WBInteraction000040606
WBInteraction000040608
WBInteraction000042986
WBInteraction000044447
WBInteraction000045204
WBInteraction000047118
WBInteraction000047949
WBInteraction000049552
WBInteraction000050376
WBInteraction000050499
WBInteraction000052907
WBInteraction000103028
WBInteraction000120532
WBInteraction000133667
WBInteraction000133668
WBInteraction000135180
WBInteraction000139401
WBInteraction000143724
WBInteraction000144105
WBInteraction000148409
WBInteraction000148558
WBInteraction000149533
WBInteraction000151208
WBInteraction000152736
WBInteraction000159981
WBInteraction000161049
WBInteraction000163391
WBInteraction000169733
WBInteraction000169734
WBInteraction000169735
WBInteraction000176933
WBInteraction000177682
WBInteraction000180131
WBInteraction000180242
WBInteraction000183530
WBInteraction000188508
WBInteraction000191156
WBInteraction000191157
WBInteraction000191797
WBInteraction000193392
WBInteraction000198685
WBInteraction000203181
WBInteraction000204873
WBInteraction000205137
WBInteraction000206389
WBInteraction000206854
WBInteraction000208533
WBInteraction000218712
WBInteraction000219446
WBInteraction000230572
WBInteraction000231958
WBInteraction000258873
WBInteraction000267073
WBInteraction000272009
WBInteraction000279220
WBInteraction000279221
WBInteraction000282478
WBInteraction000292795
WBInteraction000294669
WBInteraction000295796
WBInteraction000298401
WBInteraction000304949
WBInteraction000308211
WBInteraction000309238
WBInteraction000309239
WBInteraction000310175
WBInteraction000310293
WBInteraction000315424
WBInteraction000331479
WBInteraction000334845
WBInteraction000335173
WBInteraction000343667
WBInteraction000347096
WBInteraction000354718
WBInteraction000359745
WBInteraction000362325
WBInteraction000365718
WBInteraction000366690
WBInteraction000367820
WBInteraction000370926
WBInteraction000370927
WBInteraction000374423
WBInteraction000377196
WBInteraction000378919
WBInteraction000385943
WBInteraction000389226
WBInteraction000397211
WBInteraction000404786
WBInteraction000407290
WBInteraction000408905
WBInteraction000428031
WBInteraction000428770
WBInteraction000428924
WBInteraction000429230
WBInteraction000431560
WBInteraction000435170
WBInteraction000435171
WBInteraction000441598
WBInteraction000443541
WBInteraction000453967
WBInteraction000455850
WBInteraction000456666
WBInteraction000463225
WBInteraction000463489
WBInteraction000463551
WBInteraction000463552
WBInteraction000464892
WBInteraction000465332
WBInteraction000465713
WBInteraction000465714
WBInteraction000466189
WBInteraction000466376
WBInteraction000467091
WBInteraction000467880
WBInteraction000468853
WBInteraction000468968
WBInteraction000468970
WBInteraction000469146
WBInteraction000470038
WBInteraction000470039
WBInteraction000470942
WBInteraction000471737
WBInteraction000471820
WBInteraction000473222
WBInteraction000473317
WBInteraction000473499
WBInteraction000473520
WBInteraction000473666
WBInteraction000473701
WBInteraction000473867
WBInteraction000474280
WBInteraction000474535
WBInteraction000474753
WBInteraction000474968
WBInteraction000475463
WBInteraction000503847
WBInteraction000520387
WBInteraction000521967
WBInteraction000525265
WBInteraction000525266
WBInteraction000534738
WBInteraction000542377
WBInteraction000542378
WBInteraction000542386
WBInteraction000542794
WBInteraction000549601
WBInteraction000552728
WBInteraction000560792
WBInteraction000561862
WBInteraction000562211
WBInteraction000562392
WBInteraction000563234
WBInteraction000565831
WBInteraction000566364
WBInteraction000566643
WBInteraction000566876
WBInteraction000567238
WBInteraction000567392
WBInteraction000569298
WBInteraction000570473
WBInteraction000572207
WBInteraction000572686
WBInteraction000572895
WBInteraction000574016
WBInteraction000574625
WBInteraction000577788
WBInteraction000580432
WBInteraction000583133
WBInteraction000585438
WBInteraction000585947
Anatomy_functionWBbtf0939
WBbtf0940
WBProcessWBbiopr:00000001
WBbiopr:00000055
Map_infoMapIIPosition-1.78616Error0.000241
PositivePositive_cloneF09E5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4588
Pseudo_map_position
Reference (38)
RemarkGene name created from parsing 'genotype' field from CGC strain informationCGC_data_submission
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene