Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00002008

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00002008SMapS_parentSequenceCHROMOSOME_II
IdentityVersion1
Name (5)
DB_infoDatabaseAceViewgene2H640
WormQTLgeneWBGene00002008
WormFluxgeneWBGene00002008
NDBlocus_tagCELE_F43E2.8
PanthergeneCAEEL|WormBase=WBGene00002008|UniProtKB=P20163
familyPTHR19375
NCBIgene174203
RefSeqproteinNM_001383885.2
NM_001306541.3
SwissProtUniProtAccP20163
TrEMBLUniProtAccV6CL98
UniProt_GCRPUniProtAccP20163
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhsp
Allele (28)
Legacy_information[C.elegansII] NMK. Encodes protein related to mammalian grp78/BiP; strongly induced by heat shock. [Heschl and Baillie 1990; BC]
StrainWBStrain00036323
WBStrain00051694
RNASeq_FPKM (74)
GO_annotation (30)
Ortholog (50)
Paralog (11)
Structured_descriptionConcise_descriptionhsp-4 encodes one of two C. elegans heat shock response 70 (hsp70) proteins homologous to mammalian grp78/BiP (glucose regulated protein 78/immunoglobulin heavy chain-binding protein, OMIM:138120); hsp-4 affects embryonic and larval viability; hsp-4 is expressed in several tissues including the hypodermis, intestine, and spermatheca; hsp-4 transcription is upregulated in response to endoplasmic reticulum stress induced by dithiothreitol (DTT) or tunicamycin (unfolded protein response) as well as in response to heat shock and treatment of animals with pore-forming toxins such as Cry5B.Paper_evidenceWBPaper00001136
WBPaper00001320
WBPaper00005036
WBPaper00005044
WBPaper00006395
WBPaper00024269
WBPaper00031857
WBPaper00032255
WBPaper00005432
Curator_confirmedWBPerson48
WBPerson1843
Date_last_updated25 Oct 2013 00:00:00
Automated_descriptionEnables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in endoplasmic reticulum unfolded protein response. Located in rough endoplasmic reticulum. Expressed in PVDL; PVDR; intestinal muscle; and spermatheca. Human ortholog(s) of this gene implicated in several diseases, including dopamine beta-hydroxylase deficiency; inflammatory bowel disease; and rheumatoid arthritis. Is an ortholog of human HSPA5 (heat shock protein family A (Hsp70) member 5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:7148Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5238)
DOID:3070Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5238)
DOID:0090145Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5238)
DOID:0050589Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5238)
Molecular_infoCorresponding_CDSF43E2.8a
F43E2.8b
Corresponding_transcriptF43E2.8a.1
F43E2.8a.2
F43E2.8b.1
Other_sequence (44)
Associated_featureWBsf650221
WBsf650222
WBsf650223
WBsf665682
WBsf665683
WBsf988418
WBsf1012519
Experimental_infoRNAi_result (26)
Expr_pattern (17)
Drives_constructWBCnstr00002743
WBCnstr00005157
WBCnstr00009660
WBCnstr00013152
WBCnstr00014616
WBCnstr00016655
WBCnstr00018297
WBCnstr00020788
WBCnstr00036525
Construct_productWBCnstr00020788
WBCnstr00036525
Microarray_results (19)
Expression_cluster (233)
InteractionWBInteraction000003486
WBInteraction000003487
WBInteraction000003955
WBInteraction000004004
WBInteraction000004005
WBInteraction000005529
WBInteraction000005799
WBInteraction000008978
WBInteraction000008991
WBInteraction000008992
WBInteraction000029498
WBInteraction000029499
WBInteraction000029851
WBInteraction000030873
WBInteraction000030874
WBInteraction000103549
WBInteraction000103652
WBInteraction000103747
WBInteraction000104294
WBInteraction000104358
WBInteraction000104374
WBInteraction000104577
WBInteraction000104622
WBInteraction000104705
WBInteraction000104961
WBInteraction000106017
WBInteraction000108938
WBInteraction000109597
WBInteraction000109604
WBInteraction000109945
WBInteraction000110016
WBInteraction000114417
WBInteraction000119444
WBInteraction000119973
WBInteraction000122705
WBInteraction000122706
WBInteraction000122707
WBInteraction000122708
WBInteraction000122709
WBInteraction000122710
WBInteraction000123197
WBInteraction000123717
WBInteraction000133958
WBInteraction000136857
WBInteraction000141183
WBInteraction000157957
WBInteraction000157960
WBInteraction000158008
WBInteraction000158388
WBInteraction000158389
WBInteraction000158390
WBInteraction000158391
WBInteraction000158392
WBInteraction000158393
WBInteraction000158612
WBInteraction000158944
WBInteraction000159137
WBInteraction000159299
WBInteraction000159390
WBInteraction000162317
WBInteraction000162323
WBInteraction000162648
WBInteraction000162652
WBInteraction000163343
WBInteraction000164698
WBInteraction000165872
WBInteraction000167277
WBInteraction000167278
WBInteraction000167279
WBInteraction000167280
WBInteraction000167281
WBInteraction000167282
WBInteraction000167683
WBInteraction000167693
WBInteraction000169411
WBInteraction000169412
WBInteraction000170005
WBInteraction000174215
WBInteraction000189587
WBInteraction000189588
WBInteraction000203607
WBInteraction000249334
WBInteraction000281105
WBInteraction000289626
WBInteraction000306262
WBInteraction000315325
WBInteraction000318316
WBInteraction000334296
WBInteraction000335848
WBInteraction000338651
WBInteraction000343013
WBInteraction000349532
WBInteraction000352403
WBInteraction000369742
WBInteraction000372210
WBInteraction000375238
WBInteraction000387013
WBInteraction000387490
WBInteraction000420280
WBInteraction000424355
WBInteraction000432063
WBInteraction000434511
WBInteraction000436152
WBInteraction000438408
WBInteraction000449107
WBInteraction000452446
WBInteraction000454953
WBInteraction000455627
WBInteraction000463885
WBInteraction000464775
WBInteraction000465327
WBInteraction000472736
WBInteraction000474495
WBInteraction000474524
WBInteraction000501550
WBInteraction000501551
WBInteraction000502115
WBInteraction000502116
WBInteraction000502117
WBInteraction000502118
WBInteraction000502119
WBInteraction000502120
WBInteraction000502121
WBInteraction000502122
WBInteraction000502123
WBInteraction000502374
WBInteraction000502375
WBInteraction000502624
WBInteraction000502625
WBInteraction000502985
WBInteraction000503015
WBInteraction000503451
WBInteraction000503457
WBInteraction000503633
WBInteraction000503771
WBInteraction000503783
WBInteraction000503811
WBInteraction000503986
WBInteraction000503988
WBInteraction000504343
WBInteraction000504603
WBInteraction000504604
WBInteraction000504842
WBInteraction000517784
WBInteraction000518806
WBInteraction000519532
WBInteraction000519541
WBInteraction000519594
WBInteraction000519597
WBInteraction000519600
WBInteraction000520400
WBInteraction000520515
WBInteraction000520516
WBInteraction000520518
WBInteraction000520519
WBInteraction000520578
WBInteraction000520579
WBInteraction000520583
WBInteraction000520593
WBInteraction000520597
WBInteraction000520605
WBInteraction000520608
WBInteraction000520647
WBInteraction000520648
WBInteraction000520649
WBInteraction000520650
WBInteraction000520651
WBInteraction000520652
WBInteraction000520653
WBInteraction000520677
WBInteraction000520678
WBInteraction000520679
WBInteraction000520680
WBInteraction000520681
WBInteraction000520683
WBInteraction000520698
WBInteraction000520855
WBInteraction000521070
WBInteraction000521896
WBInteraction000523392
WBInteraction000523393
WBInteraction000523945
WBInteraction000535210
WBInteraction000535211
WBInteraction000535212
WBInteraction000535213
WBInteraction000535214
WBInteraction000535215
WBInteraction000535216
WBInteraction000535217
WBInteraction000535218
WBInteraction000535219
WBInteraction000535220
WBInteraction000535221
WBInteraction000535222
WBInteraction000535223
WBInteraction000535224
WBInteraction000535225
WBInteraction000535226
WBInteraction000535227
WBInteraction000535228
WBInteraction000535229
WBInteraction000535230
WBInteraction000535231
WBInteraction000535232
WBInteraction000535233
WBInteraction000535234
WBInteraction000535235
WBInteraction000535236
WBInteraction000535237
WBInteraction000535238
WBInteraction000535239
WBInteraction000535398
WBInteraction000535431
WBInteraction000535432
WBInteraction000536212
WBInteraction000536214
WBInteraction000536217
WBInteraction000536415
WBInteraction000536416
WBInteraction000536417
WBInteraction000536424
WBInteraction000536425
WBInteraction000536426
WBInteraction000536432
WBInteraction000536433
WBInteraction000536434
WBInteraction000536435
WBInteraction000536436
WBInteraction000536443
WBInteraction000536515
WBInteraction000536516
WBInteraction000536517
WBInteraction000536519
WBInteraction000536520
WBInteraction000536522
WBInteraction000536523
WBInteraction000536608
WBInteraction000536683
WBInteraction000536747
WBInteraction000536748
WBInteraction000536749
WBInteraction000536750
WBInteraction000536751
WBInteraction000536752
WBInteraction000536753
WBInteraction000536754
WBInteraction000536755
WBInteraction000536756
WBInteraction000536768
WBInteraction000536769
WBInteraction000536770
WBInteraction000536771
WBInteraction000536772
WBInteraction000536777
WBInteraction000536788
WBInteraction000536791
WBInteraction000536792
WBInteraction000536793
WBInteraction000536794
WBInteraction000536797
WBInteraction000536798
WBInteraction000536799
WBInteraction000536800
WBInteraction000536801
WBInteraction000536802
WBInteraction000536805
WBInteraction000536806
WBInteraction000536807
WBInteraction000536808
WBInteraction000536809
WBInteraction000536819
WBInteraction000536820
WBInteraction000536822
WBInteraction000536823
WBInteraction000536824
WBInteraction000536830
WBInteraction000536833
WBInteraction000536835
WBInteraction000536843
WBInteraction000536845
WBInteraction000536869
WBInteraction000536871
WBInteraction000536963
WBInteraction000536970
WBInteraction000536971
WBInteraction000536972
WBInteraction000536975
WBInteraction000537213
WBInteraction000537214
WBInteraction000537215
WBInteraction000537216
WBInteraction000537217
WBInteraction000537218
WBInteraction000537219
WBInteraction000537220
WBInteraction000537221
WBInteraction000537222
WBInteraction000537223
WBInteraction000537224
WBInteraction000537225
WBInteraction000537226
WBInteraction000537227
WBInteraction000537228
WBInteraction000537229
WBInteraction000537230
WBInteraction000537231
WBInteraction000537232
WBInteraction000537233
WBInteraction000537234
WBInteraction000537235
WBInteraction000537236
WBInteraction000537237
WBInteraction000537238
WBInteraction000537239
WBInteraction000537240
WBInteraction000537241
WBInteraction000537242
WBInteraction000537243
WBInteraction000537244
WBInteraction000537245
WBInteraction000537435
WBInteraction000537438
WBInteraction000537576
WBInteraction000539702
WBInteraction000540383
WBInteraction000541097
WBInteraction000541098
WBInteraction000542357
WBInteraction000542358
WBInteraction000542377
WBInteraction000542378
WBInteraction000542386
WBInteraction000542515
WBInteraction000542605
WBInteraction000542606
WBInteraction000542607
WBInteraction000542608
WBInteraction000542609
WBInteraction000542610
WBInteraction000542611
WBInteraction000542612
WBInteraction000542613
WBInteraction000542614
WBInteraction000542615
WBInteraction000542616
WBInteraction000542617
WBInteraction000542618
WBInteraction000542619
WBInteraction000542620
WBInteraction000542621
WBInteraction000542622
WBInteraction000542623
WBInteraction000542624
WBInteraction000542625
WBInteraction000542626
WBInteraction000542627
WBInteraction000542628
WBInteraction000542629
WBInteraction000542630
WBInteraction000542631
WBInteraction000542632
WBInteraction000542633
WBInteraction000542634
WBInteraction000542635
WBInteraction000543347
WBInteraction000548206
WBInteraction000549905
WBInteraction000549925
WBInteraction000549952
WBInteraction000549953
WBInteraction000549954
WBInteraction000551285
WBInteraction000552142
WBInteraction000561756
WBInteraction000563094
WBInteraction000567218
WBInteraction000567387
WBInteraction000569605
WBInteraction000571276
WBInteraction000571322
WBInteraction000571527
WBInteraction000571533
WBInteraction000571534
WBInteraction000571535
WBInteraction000571539
WBInteraction000571541
WBInteraction000571544
WBInteraction000571547
WBInteraction000571548
WBInteraction000571553
WBInteraction000571554
WBInteraction000571979
WBInteraction000573441
WBInteraction000577368
WBInteraction000580073
WBInteraction000584559
WBInteraction000584635
WBInteraction000586208
WBProcessWBbiopr:00000046
WBbiopr:00000076
WBbiopr:00000079
WBbiopr:00000121
Map_infoMapIIPosition0.502202Error0.000194
PositivePositive_cloneF43E2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5625
4390
Pseudo_map_position
Reference (124)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene