WormBase Tree Display for Interaction: WBInteraction000542627

WBInteraction000542627 Interaction_type: Regulatory: Change_of_expression_level
  Interactor: Interactor_overlapping_gene: WBGene00017578 Interactor_type: Trans_regulator
      WBGene00002008 Interactor_type: Trans_regulated
      WBGene00001752 Interactor_type: Trans_regulated
  Interaction_summary: "We observe the greatest degree of regulation, however, amongst the 16 regulators of cytoprotective gene expression that regulate 2 or more of the tested cytoprotective pathways. lin-40 gene inactivation disrupts psod-3::gfp induction 17-fold, and pgst-4::gfp 2-fold. let-92 gene inactivation results in the most potent disruption of pgst-4::gfp induction, decreasing expression 25-fold, and inhibiting induction of psod-3::gfp and phsp-6::gfp by 3- and 4-fold, respectively. ima-3 and elt-2 gene inactivations both dramatically decrease induction of phsp-6::gfp by antimycin. ima-3 gene inactivation additionally inhibits the induction of pgst-4::gfp (4-fold). elt-2, like let-70 and cpsf-2, is required for the appropriate regulation of all four tested cytoprotective pathways (Table 1, Figure 1)."
  Detection_method: Reporter_gene: [hsp-4p::gfp], [gst-4p::gfp]
  Regulation_level: Transcriptional
  Paper: WBPaper00041330
  Remark: Table 1, Fig. 1