WormBase Tree Display for Interaction: WBInteraction000542605

WBInteraction000542605 Interaction_type: Regulatory: Change_of_expression_level
  Interactor: Interactor_overlapping_gene: WBGene00006733 Interactor_type: Trans_regulator
      WBGene00006351 Interactor_type: Trans_regulated
      WBGene00002016 Interactor_type: Trans_regulated
      WBGene00002008 Interactor_type: Trans_regulated
      WBGene00004932 Interactor_type: Trans_regulated
      WBGene00001752 Interactor_type: Trans_regulated
  Interaction_summary: "We observe the greatest degree of regulation, however, amongst the 16 regulators of cytoprotective gene expression that regulate 2 or more of the tested cytoprotective pathways. lin-40 gene inactivation disrupts psod-3::gfp induction 17-fold, and pgst-4::gfp 2-fold. let-92 gene inactivation results in the most potent disruption of pgst-4::gfp induction, decreasing expression 25-fold, and inhibiting induction of psod-3::gfp and phsp-6::gfp by 3- and 4-fold, respectively. ima-3 and elt-2 gene inactivations both dramatically decrease induction of phsp-6::gfp by antimycin. ima-3 gene inactivation additionally inhibits the induction of pgst-4::gfp (4-fold). elt-2, like let-70 and cpsf-2, is required for the appropriate regulation of all four tested cytoprotective pathways (Table 1, Figure 1)... Induction of phsp-16.2::gfp following heat shock and the expression of a non-stress-induced fusion gene, psur-5::gfp, were quantified to control for generic transgene silencing phenotypes; none of these gene inactivations were potent transgene silencers (Table S4)"
  Detection_method: Reporter_gene: [hsp-4p::gfp], [sod-3p::gfp], [gst-4p::gfp], [hsp-16.2p::gfp], [sur-5p::gfp]
  Regulation_level: Transcriptional
  Paper: WBPaper00041330
  Remark: Table 1, Fig. 1, Table S4; hsp-16.2::gfp induced via 37C treatment for 1hr