WormBase Tree Display for Gene: WBGene00001145

WBGene00001145 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C16C2
  Identity: Version: 1
    Name: CGC_name: eat-16 Person_evidence: WBPerson32
      Sequence_name: C16C2.2
      Molecular_name: C16C2.2a
        C16C2.2a.1
        CE17404
        C16C2.2b
        CE30491
        C16C2.2b.1
      Other_name: sag-2
        CELE_C16C2.2 Accession_evidence: NDB BX284601
      Public_name: eat-16
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: eat
    Allele (53)
    Legacy_information: [Leon Avery] Strong Eat: slippery isthmus and corpus.
      See also ad702
      [C.elegansII] ad702 : strong Eat: slippery isthmus and corpus. [Avery 1993; DA]
    Strain: WBStrain00022805
      WBStrain00023483
      WBStrain00026411
      WBStrain00004787
      WBStrain00005505
      WBStrain00022017
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (38)
    Paralog: WBGene00001179 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004344 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004345 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004347 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004349 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004350 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: The eat-16 gene encodes an RGS protein that affects movement, pharyngeal pumping, egg laying, and synaptic transmission; it genetically interacts with the egl-30 and goa-1 signaling pathways, and is expressed in excitable cells and in the spermatheca. Paper_evidence: WBPaper00004713
            WBPaper00004721
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables GTPase activator activity. Involved in several processes, including phospholipase C-inhibiting G protein-coupled receptor signaling pathway; regulation of cell communication; and response to monoamine. Located in cytoplasm; neuron projection; and plasma membrane. Expressed in HSNL; HSNR; neurons; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in bradyopsia 1. Is an ortholog of human RGS9 (regulator of G protein signaling 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070363 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10004)
  Molecular_info: Corresponding_CDS: C16C2.2a
      C16C2.2b
    Corresponding_CDS_history: C16C2.2:wp77
    Corresponding_transcript: C16C2.2a.1
      C16C2.2b.1
    Other_sequence (34)
    Associated_feature: WBsf643615
      WBsf655796
      WBsf656787
      WBsf218329
      WBsf218330
      WBsf218331
  Experimental_info: RNAi_result (16)
    Expr_pattern: Expr1333
      Expr8085
      Expr8866
      Expr8867
      Expr1022292
      Expr1030727
      Expr1144733
      Expr2011152
      Expr2029388
    Drives_construct: WBCnstr00004867
      WBCnstr00005925
      WBCnstr00010225
      WBCnstr00013101
    Construct_product: WBCnstr00004867
      WBCnstr00005925
      WBCnstr00010225
      WBCnstr00013101
    Antibody: WBAntibody00002110
    Microarray_results (33)
    Expression_cluster (105)
    Interaction: WBInteraction000000884
      WBInteraction000000885
      WBInteraction000000886
      WBInteraction000000888
      WBInteraction000000889
      WBInteraction000001232
      WBInteraction000001368
      WBInteraction000002695
      WBInteraction000004837
      WBInteraction000004838
      WBInteraction000004929
      WBInteraction000009819
      WBInteraction000009901
      WBInteraction000029271
      WBInteraction000030415
      WBInteraction000052107
      WBInteraction000126131
      WBInteraction000126132
      WBInteraction000126133
      WBInteraction000126134
      WBInteraction000126359
      WBInteraction000126370
      WBInteraction000126464
      WBInteraction000127114
      WBInteraction000144306
      WBInteraction000165707
      WBInteraction000171195
      WBInteraction000202360
      WBInteraction000215822
      WBInteraction000317800
      WBInteraction000435669
      WBInteraction000439537
      WBInteraction000446853
      WBInteraction000474328
      WBInteraction000500836
      WBInteraction000517387
      WBInteraction000518037
      WBInteraction000519689
      WBInteraction000519703
      WBInteraction000524571
      WBInteraction000524573
      WBInteraction000540263
      WBInteraction000542427
      WBInteraction000542431
      WBInteraction000542435
      WBInteraction000542439
      WBInteraction000549801
      WBInteraction000549808
      WBInteraction000551160
      WBInteraction000551161
      WBInteraction000551162
      WBInteraction000563787
      WBInteraction000571237
      WBInteraction000571242
    Anatomy_function: WBbtf0195
      WBbtf0990
  Map_info (5)
  Reference (94)
  Remark: Interacting_genes '[Leon Avery] unc-31: Partially suppresses the Unc phenotype of unc-31.
    Sequence From: paul sternberg via ACEDB feedback page <pws@caltech.edu>
    Sequence connection from [Hadju-Cronin YM, Sternberg PS]
    old_name sag-2 becomes new_name eat-16 from [Hadju-Cronin Y, Sternberg PW].
  Method: Gene