WormBase Tree Display for Gene: WBGene00006869
expand all nodes | collapse all nodes | view schema
| WBGene00006869 | SMap | S_parent | Sequence | Y37E11AR | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | vab-2 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y37E11AR.6 | ||||||||
| Molecular_name | Y37E11AR.6a | ||||||||
| Y37E11AR.6a.1 | |||||||||
| CE27606 | |||||||||
| Y37E11AR.6b | |||||||||
| CE48555 | |||||||||
| Y37E11AR.6b.1 | |||||||||
| Other_name | efn-1 | ||||||||
| Y37E11AR.a | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| Y37E11AR.f | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y37E11AR.6 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | vab-2 | ||||||||
| DB_info | Database | AceView | gene | 4E526 | |||||
| WormQTL | gene | WBGene00006869 | |||||||
| WormFlux | gene | WBGene00006869 | |||||||
| NDB | locus_tag | CELE_Y37E11AR.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006869|UniProtKB=G5EEE7 | |||||||
| family | PTHR11304 | ||||||||
| NCBI | gene | 177140 | |||||||
| RefSeq | protein | NM_001307367.3 | |||||||
| NM_068011.4 | |||||||||
| TrEMBL | UniProtAcc | U4PQX3 | |||||||
| G5EEE7 | |||||||||
| UniProt_GCRP | UniProtAcc | G5EEE7 | |||||||
| OMIM | gene | 300035 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vab | ||||||||
| Reference_allele | WBVar00142958 | ||||||||
| Allele (103) | |||||||||
| Legacy_information | e96 : notched head especially in L1; resembles vab-1 alleles; penetrance 65%. ES3/0 ME3. NA3 (e141 e1208 : penetrance 50%). | ||||||||
| See also e96, e141, e1208 | |||||||||
| [C.elegansII] e96 : notched head, especially in L1; resembles vab-1 alleles; penetrance 65%. ES3/0 ME3. OA3: e141, e1208 (penetrance 50%), sy167. [Brenner 1974; Lewis and Hodgkin 1979; CB; CZ] | |||||||||
| Strain | WBStrain00004098 | ||||||||
| WBStrain00005375 | |||||||||
| WBStrain00005393 | |||||||||
| WBStrain00005671 | |||||||||
| WBStrain00008621 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00001163 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00001164 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001165 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | The vab-2 gene encodes an ephrin molecule related to human ephrin B2 (OMIM:600527); VAB-2, expressed primarily in neuronal cells, is a ligand for the VAB-1 ephrin receptor and plays a role in embryonic cell movements, epidermal morphogenesis during later embryogenesis, and oocyte maturation; VAB-2 synergizes with PTP-3, a LAR-like receptor tyrosine phosphatase, to regulate morphogenesis. | Paper_evidence | WBPaper00005237 | |||||
| WBPaper00005259 | |||||||||
| WBPaper00005631 | |||||||||
| WBPaper00005670 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway and epidermis morphogenesis. Located in axon and external side of plasma membrane. Expressed in several structures, including anterior ganglion; neuroblasts; neurons; somatic nervous system; and ventral ganglion (post). Human ortholog(s) of this gene implicated in craniofrontonasal syndrome; dysostosis; and stomach cancer. Is an ortholog of human EFNB1 (ephrin B1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1934 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3226) | ||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3226) | ||||||
| DOID:14737 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3226) | ||||||
| Molecular_info | Corresponding_CDS | Y37E11AR.6a | |||||||
| Y37E11AR.6b | |||||||||
| Corresponding_transcript | Y37E11AR.6a.1 | ||||||||
| Y37E11AR.6b.1 | |||||||||
| Other_sequence | JI465448.1 | ||||||||
| EX564327.1 | |||||||||
| EX566143.1 | |||||||||
| Dviv_isotig15487 | |||||||||
| Acan_isotig10223 | |||||||||
| ACC08414_1 | |||||||||
| Associated_feature (23) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00036800 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00055914 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00020222 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00020228 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00064657 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00064737 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1106 | ||||||||
| Expr1108 | |||||||||
| Expr11225 | |||||||||
| Expr1016061 | |||||||||
| Expr1032911 | |||||||||
| Expr1159434 | |||||||||
| Expr2017950 | |||||||||
| Expr2036086 | |||||||||
| Drives_construct (3) | |||||||||
| Construct_product | WBCnstr00000712 | ||||||||
| WBCnstr00017935 | |||||||||
| WBCnstr00034119 | |||||||||
| Antibody | WBAntibody00000261 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (146) | |||||||||
| Interaction (22) | |||||||||
| Map_info (4) | |||||||||
| Reference (64) | |||||||||
| Remark | Data extracted from Chin-Sang et al. by JAH. | ||||||||
| Positive_clone is based on fosmid rescue [Chin-Sang ID][030403 ck1] | |||||||||
| Method | Gene |
