WormBase Tree Display for Gene: WBGene00004206
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| WBGene00004206 | Evidence | Person_evidence | WBPerson1705 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | M03F8 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | pst-1 | Person_evidence | WBPerson260 | |||||
| Sequence_name | M03F8.2 | ||||||||
| Molecular_name (16) | |||||||||
| Other_name | let-462 | Paper_evidence | WBPaper00035477 | ||||||
| Person_evidence | WBPerson533 | ||||||||
| CELE_M03F8.2 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | pst-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 03 Dec 2009 13:15:13 | WBPerson2970 | Event | Acquires_merge | WBGene00002674 | ||||
| Name_change | Other_name | let-462 | |||||||
| Acquires_merge | WBGene00002674 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pst | ||||||||
| Reference_allele | WBVar00242153 | ||||||||
| Allele (120) | |||||||||
| Legacy_information | Early-mid larval | ||||||||
| [C.elegansII] s1594 : embryonic/early larval lethal. OA3: s1481 (larval lethal, molting problem), s1590, s1956uvi. [Johnsen and Baillie 1991; BC] | |||||||||
| Strain | WBStrain00000589 | ||||||||
| WBStrain00000727 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Contained_in_operon | CEOP5092 | ||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00018827 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00017480 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00013740 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00008275 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | pst-1 encodes the C. elegans ortholog of the vertebrate PAPST1 PAPS (3'-phosphoadenosine-5'-phosphosulfate) transporter and Drosophila Slalom; pst-1 is required in vivo for heparan sulfation; pst-1 is an essential gene, required both maternally and zygotically for late embryonic and larval development; pst-1 is also required for a subset of neuronal and axonal migrations and for presynaptic development in motor, and possibly touch, neurons; in regulating these developmental processes, pst-1 can function cell non-autonomously; pst-1::gfp is first detected at the two-fold stage of embryogenesis in hypodermal cells; later, pst-1::gfp expression is seen in the seam cells, pharyngeal gland cells, additional anterior cells and possibly in the intestine; PST-1::GFP shows partial localization to the Golgi. | Paper_evidence | WBPaper00005236 | |||||
| WBPaper00035477 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 18 Mar 2010 00:00:00 | ||||||||
| Automated_description | Enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate transport. Located in Golgi cisterna membrane. Expressed in AMshL; AMshR; pharyngeal gland cell; and seam cell. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 26. Is an ortholog of human SLC35B2 (solute carrier family 35 member B2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070403 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16872) | ||||
| Molecular_info (5) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00082865 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00017166 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000639 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034413 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050882 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094960 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8856 | ||||||||
| Expr8858 | |||||||||
| Expr9061 | |||||||||
| Expr9063 | |||||||||
| Expr1011961 | |||||||||
| Expr1032063 | |||||||||
| Expr1154575 | |||||||||
| Expr2015139 | |||||||||
| Expr2033377 | |||||||||
| Drives_construct | WBCnstr00007894 | ||||||||
| WBCnstr00007895 | |||||||||
| WBCnstr00007896 | |||||||||
| WBCnstr00007897 | |||||||||
| WBCnstr00013565 | |||||||||
| WBCnstr00013567 | |||||||||
| WBCnstr00013693 | |||||||||
| WBCnstr00035638 | |||||||||
| Construct_product | WBCnstr00007883 | ||||||||
| WBCnstr00007885 | |||||||||
| WBCnstr00007890 | |||||||||
| WBCnstr00007891 | |||||||||
| WBCnstr00013565 | |||||||||
| WBCnstr00013567 | |||||||||
| WBCnstr00013693 | |||||||||
| WBCnstr00035638 | |||||||||
| Microarray_results (36) | |||||||||
| Expression_cluster (97) | |||||||||
| Interaction (30) | |||||||||
| Map_info | Map | V | Position | -0.722265 | Error | 0.010879 | |||
| Positive | Positive_clone | M03F8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Pos_neg_data | 5747 | |||||||
| 5748 | |||||||||
| 8406 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
