WormBase Tree Display for Gene: WBGene00002990
expand all nodes | collapse all nodes | view schema
| WBGene00002990 | SMap | S_parent | Sequence | C37F5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lin-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C37F5.1 | ||||||||
| Molecular_name | C37F5.1a | ||||||||
| C37F5.1a.1 | |||||||||
| CE31440 | |||||||||
| C37F5.1b | |||||||||
| CE27833 | |||||||||
| C37F5.1b.1 | |||||||||
| Other_name | elk-1 | Person_evidence | WBPerson260 | ||||||
| CELE_C37F5.1 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | lin-1 | ||||||||
| DB_info | Database | AceView | gene | 4D42 | |||||
| WormQTL | gene | WBGene00002990 | |||||||
| SignaLink | protein | WBGene00002990 | |||||||
| WormFlux | gene | WBGene00002990 | |||||||
| NDB | locus_tag | CELE_C37F5.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002990|UniProtKB=G5EDL0 | |||||||
| family | PTHR11849 | ||||||||
| NCBI | gene | 177016 | |||||||
| RefSeq | protein | NM_001027880.5 | |||||||
| NM_001307372.2 | |||||||||
| TrEMBL | UniProtAcc | U4PLN0 | |||||||
| G5EDL0 | |||||||||
| UniProt_GCRP | UniProtAcc | G5EDL0 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 08 Nov 2011 16:15:59 | WBPerson2970 | Name_change | Other_name | elk-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Reference_allele | WBVar00144296 | ||||||||
| Allele (643) | |||||||||
| Legacy_information | e1777amber : adult hermaphrodite has multiple (one to four) vulval protrusions often bursts at abnormal vulva during L4 molt; ES3 (adult)/ ES1 (larvae); HME2; adult male has redimentary ectopic hooks ES1 ME0. NA16 (e1026 n431amber (phenotype resembles e1777) e1275 (weaker slightly ts phenotype ME1) etc.). | ||||||||
| See also e1026, e1275, e1777, n176, n303, n304, n381, n383, n430, n431, n746, n753, n757, n1047, n1054, n1140, n1141 | |||||||||
| [Beitel G and Tuck S] e1777, although an amber mutation, is not NULL. | Paper_evidence | WBPaper00002125 | |||||||
| WBPaper00002352 | |||||||||
| [C.elegansII] e1777amb : adult hermaphrodite has multiple (one to four) vulval protrusions, often bursts at abnormal vulva during L4 molt; ES3 (adult)/ ES1 (larvae); HME2; adult male has rudimentary ectopic hooks ES1 ME0. OA>20: e1026, n431amb (phenotype resembles e1777), e1275 (weaker, slightly ts phenotype; ME1), n746, n1141 etc. Cloned: encodes predicted protein with strong similarity to ETS family transcription factors. [Ferguson et al. 1985; Katz et al. 1995; GS; MT] | |||||||||
| Strain (27) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (31) | |||||||||
| Contained_in_operon | CEOP4648 | ||||||||
| Ortholog (40) | |||||||||
| Paralog (11) | |||||||||
| Structured_description | Concise_description | lin-1 encodes an Ets-domain-containing transcription factor that is a member of the ETS gene family that includes human ELK1, 3, and 4 (OMIM:600247); LIN-1 functions as a general effector of MAP kinase-mediated signaling; when MAP kinase is inactive, LIN-1 forms a complex with LIN-31/WH that inhibits vulval cell fate specification; upon MAP kinase activation (vulval induction), LIN-1 is phosphorylated, dissociates from LIN-31, and becomes inactive, thus allowing for vulval development. | Paper_evidence | WBPaper00000496 | |||||
| WBPaper00003087 | |||||||||
| WBPaper00005344 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 01 Feb 2006 00:00:00 | ||||||||
| Automated_description | Enables sequence-specific DNA binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; negative regulation of transcription by RNA polymerase II; and vulval development. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Expressed in vulval precursor cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Lewy body dementia; and schizophrenia. Is an ortholog of human ELK1 (ETS transcription factor ELK1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:12217 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3321) | ||||
| DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3321) | ||||||
| DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3321) | ||||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3321) | ||||||
| Molecular_info | Corresponding_CDS | C37F5.1a | |||||||
| C37F5.1b | |||||||||
| Corresponding_CDS_history | C37F5.1:wp82 | ||||||||
| Corresponding_transcript | C37F5.1a.1 | ||||||||
| C37F5.1b.1 | |||||||||
| Associated_feature (35) | |||||||||
| Gene_product_binds | WBsf034358 | ||||||||
| WBsf034359 | |||||||||
| WBsf047656 | |||||||||
| WBsf919592 | |||||||||
| WBsf919593 | |||||||||
| WBsf919594 | |||||||||
| WBsf977956 | |||||||||
| Transcription_factor | WBTranscriptionFactor000135 | ||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern | Chronogram1167 | ||||||||
| Expr5464 | |||||||||
| Expr10344 | |||||||||
| Expr11522 | |||||||||
| Expr1023535 | |||||||||
| Expr1031389 | |||||||||
| Expr1146119 | |||||||||
| Expr2013165 | |||||||||
| Expr2031397 | |||||||||
| Drives_construct | WBCnstr00003801 | ||||||||
| WBCnstr00015268 | |||||||||
| Antibody | WBAntibody00001826 | ||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (244) | |||||||||
| WBProcess | WBbiopr:00000020 | ||||||||
| WBbiopr:00000024 | |||||||||
| WBbiopr:00000121 | |||||||||
| Map_info (5) | |||||||||
| Reference (249) | |||||||||
| Picture | WBPicture0000013092 | ||||||||
| Method | Gene |
