cc8266te : pharyngeal defects, poor feeding, some larval arrest. OA1: pk40tci Encodes protein related (83%) to NK-2 of Drosophila. Candidate binding protein for myo-2 enhancer. ceh-22:lacZ expressed in pharyngeal muscle. [Okkema and Fire 1994]
[C.elegansII] cc8266te : pharyngeal defects, poor feeding, some larval arrest. OA1: pk40tci Encodes protein related (83%) to NK-2 of Drosophila.Candidate binding protein for myo-2 enhancer. ceh-22:lacZ expressed in pharyngeal muscle. [Okkema and Fire 1994]
ceh-22 encodes an NK-2 family homeodomain factor homologous to Drosophila TINMAN and vertebrate Nkx2-5 proteins; CEH-22 activates pharyngeal muscle gene expression in combination with PHA-1 and is required for normal pharyngeal development; ceh-22 is the first gene known to be expressed in pharyngeal muscles, being exclusively active in that tissue.
Enables sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; pharyngeal muscle development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including G1; gonad; neurons; pharyngeal cell; and ventral nerve cord. Used to study cancer. Is an ortholog of human NKX2-2 (NK2 homeobox 2).