n301 : adult hermaphrodite Muv vulva either functional or nonfunctional protrusion 0-4 small ventral protrusions. ES3. Male gross morphology wildtype ME0. Similar phenotype in n301/Df. NA11 (e1750 n376 etc.).
[C.elegansII] n301 : adult hermaphrodite Muv, vulva either functional or nonfunctional protrusion; 0-4 small ventral protrusions. VPC cells adopt 1ary/2ary/3ary fate at random.ES3 (adult). Male gross morphology wildtype ME0. Similar phenotype in n301/Df. Mosaic analysis indicates cell-autonomous action.OA>10: e1750, e2181, n376, n428, n1301 etc. Cloned: 1.5 transcript, expressed throughout development, encodes predicted 237 aa protein with similarity to fork head/HNF-3 transcription factors. lin-31:GFP expressed in P3.p - P8.p. [Miller et al. 1993; SD]
lin-31 encodes a winged helix (WH)-like transcription factor that is a member of the HNF3/Forkhead family of DNA-binding proteins; LIN-31 acts as a tissue-specific effector of MAP kinase-mediated signaling in the vulva; when MAP kinase is inactive, LIN-31 forms a complex with LIN-1/Ets that inhibits vulval cell fates; upon MAP kinase activation (vulval induction), LIN-31 becomes phosphorylated, dissociates from LIN-1, and goes on to promote primary and secondary vulval cell fates; LIN-31 is expressed in the vulval precursor cells.
Enables sequence-specific DNA binding activity. Involved in vulval development. Located in nucleus. Expressed in several structures, including P11.p; P9.p; gonad; nerve ring; and vulval precursor cell. Is an ortholog of human FOXB2 (forkhead box B2).