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WormBase Tree Display for Gene: WBGene00000253

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Name Class

WBGene00000253EvidenceCGC_data_submission
SMapS_parentSequenceCHROMOSOME_I
IdentityVersion2
NameCGC_namebli-3Person_evidenceWBPerson261
Sequence_nameF56C11.1
Molecular_nameF56C11.1
F56C11.1.1
CE28463
F56C11.1.2
Other_nametag-31CGC_data_submission
duox-1Paper_evidenceWBPaper00004841
WBPaper00006395
Person_evidenceWBPerson56
CELE_F56C11.1Accession_evidenceNDBBX284601
Public_namebli-3
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
207 Sep 2009 12:21:16WBPerson9133Name_changeCGC_nameduox-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classbli
Reference_alleleWBVar00143469
Allele (139)
Legacy_informatione767 : small irregular shape variable slight blistering in adult. ES2 (adult late larvae) ME1. NA1.
See also e767, n529
[C.elegansII]e767 : small irregular shape variable slight blistering in adult. ES2 (adult late larvae) ME1. OA1: n529. [Brenner 1974; CB]
StrainWBStrain00005170
WBStrain00005171
WBStrain00005172
WBStrain00005173
WBStrain00026799
WBStrain00026835
WBStrain00027251
WBStrain00028999
WBStrain00037731
WBStrain00004204
RNASeq_FPKM (74)
GO_annotation (36)
OrthologWBGene00070507Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00027637Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00162854Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00159126Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00126923Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00114201Pristionchus pacificusFrom_analysisInparanoid_8
WormBase-Compara
WBGene00224727Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g12331Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g12206Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP21.g15043Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP21.g1901Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP21.g1902Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g6577Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP29.g11006Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g10764Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g8818Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g10795Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP38.g10796Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g17497Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g17826Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g7069Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP39.g7353Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g5320Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cnig_chr_I.g416Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g14582Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_01692.g22567Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_06360Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_001329Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g12957Oscheius tipulaeFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g12958Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g11380Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_10247800Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrI_pilon.g26Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00245165Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00262944Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00289879Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0283531Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-091117-14Danio rerioFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
OrthoInspector
SonicParanoid
HGNC:13273Homo sapiensFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
HGNC:3062Homo sapiensFrom_analysisInparanoid
OMA
OrthoFinder
OrthoInspector
SonicParanoid
MGI:3036280Mus musculusFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
RGD:628761Rattus norvegicusFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ParalogWBGene00018771Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
Structured_descriptionConcise_descriptionbli-3 encodes an NADPH oxidases of the dual oxidase (DUOX) variety that contains an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; BLI-3 is required for dityrosine cross-linking of collagen, and thus for cuticular integrity; BLI-3 is thought to use cytosolic NADPH to generate reactive oxygen, which then drives the peroxidase ectodomain to cross-link free tyrosine in collagen; BLI-3 is expressed exclusively in hypodermal cells at low levels, with peaks of expression corresponding to collagen/cuticle biosynthesis.Paper_evidenceWBPaper00000031
WBPaper00002665
WBPaper00004841
WBPaper00005747
WBPaper00033104
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated19 Aug 2009 00:00:00
Automated_descriptionEnables NAD(P)H oxidase H2O2-forming activity; heme binding activity; and peroxidase activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; defense response to other organism; and post-embryonic development. Located in plasma membrane. Expressed in hypodermis; intestine; and neurons. Used to study phenylketonuria. Human ortholog(s) of this gene implicated in cholera; inflammatory bowel disease (multiple); and thyroid dyshormonogenesis 6. Is an ortholog of human DUOX2 (dual oxidase 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:9281
Potential_modelDOID:0050328Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:13273)
DOID:8577Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:13273)
DOID:1498Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:13273)
DOID:8778Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:13273)
DOID:0112189Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:13273)
Models_disease_assertedWBDOannot00000626
Molecular_infoCorresponding_CDSF56C11.1
Corresponding_transcriptF56C11.1.1
F56C11.1.2
Other_sequence (17)
Associated_featureWBsf717434
WBsf982412
WBsf982413
WBsf982414
WBsf1009036
WBsf218873
WBsf218874
Experimental_infoRNAi_result (35)
Expr_patternExpr2613
Expr15757
Expr1010236
Expr1030163
Expr1152411
Expr2009629
Expr2027868
Drives_constructWBCnstr00021138
WBCnstr00037626
WBCnstr00042508
Construct_productWBCnstr00015484
WBCnstr00015485
WBCnstr00015489
WBCnstr00015491
WBCnstr00037626
AntibodyWBAntibody00000404
WBAntibody00002391
WBAntibody00002392
Microarray_results (21)
Expression_cluster (114)
Interaction (22)
WBProcessWBbiopr:00000039
WBbiopr:00000096
Map_infoMapIPosition-19.1485Error0.002825
Well_ordered
PositiveInside_rearrsDp2
Positive_cloneF56C11Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point1
2504
3941
4741
6080
7166
7167
7169
Multi_point (18)
Pos_neg_data6276
1026
955
4553
4554
4555
4556
Landmark_gene
ReferenceWBPaper00000031
WBPaper00000608
WBPaper00000976
WBPaper00001057
WBPaper00001328
WBPaper00001558
WBPaper00001747
WBPaper00001848
WBPaper00002339
WBPaper00004841
WBPaper00005747
WBPaper00006395
WBPaper00013709
WBPaper00013777
WBPaper00014382
WBPaper00014628
WBPaper00015350
WBPaper00016398
WBPaper00016504
WBPaper00021035
WBPaper00026596
WBPaper00027824
WBPaper00031861
WBPaper00033104
WBPaper00033201
WBPaper00033445
WBPaper00037626
WBPaper00037681
WBPaper00037982
WBPaper00038491
WBPaper00041110
WBPaper00041408
WBPaper00041607
WBPaper00041912
WBPaper00043278
WBPaper00044212
WBPaper00044344
WBPaper00044770
WBPaper00044963
WBPaper00046075
WBPaper00046081
WBPaper00046705
WBPaper00051455
WBPaper00051549
WBPaper00051802
WBPaper00055090
WBPaper00055154
WBPaper00055350
WBPaper00056090
WBPaper00059068
WBPaper00059817
WBPaper00059960
WBPaper00062245
WBPaper00064291
WBPaper00064539
WBPaper00065026
WBPaper00065123
WBPaper00065304
RemarkGene name created from parsing 'genotype' field from CGC strain informationCGC_data_submission
MethodGene