WormBase Tree Display for Gene: WBGene00004703
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WBGene00004703 | SMap | S_parent | Sequence | C33H5 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | rsp-6 | Person_evidence | WBPerson297 | |||||
Sequence_name | C33H5.12 | ||||||||
Molecular_name | C33H5.12a | ||||||||
C33H5.12a.1 | |||||||||
CE04155 | |||||||||
C33H5.12b | |||||||||
C33H5.12c | |||||||||
Other_name | srp-1 | ||||||||
CeSRp20 | |||||||||
CELE_C33H5.12 | Accession_evidence | NDB | BX284604 | ||||||
Public_name | rsp-6 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | rsp | ||||||||
Allele (26) | |||||||||
Strain | WBStrain00035906 | ||||||||
Component_of_genotype | WBGenotype00000093 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (21) | |||||||||
Contained_in_operon | CEOP4252 | ||||||||
Ortholog (44) | |||||||||
Paralog | WBGene00004315 | Caenorhabditis elegans | From_analysis | Panther | |||||
WBGene00004701 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WBGene00013293 | Caenorhabditis elegans | From_analysis | Panther | ||||||
Structured_description | Concise_description | rsp-6 encodes an RNA binding protein that is the C. elegans ortholog of the vertebrate SFRS3/SRp20 pre-mRNA splicing factors; although loss of rsp-6 activity alone results in no obvious abnormalities, RNAi experiments targeting multiple RSP proteins indicate that, in combination with other RSP proteins, RSP-6 plays a role in embryonic and larval development, germline sex determination (sperm-oocyte switch), somatic gonad and vulval development, body morphology, gut function, and normal growth rates; in addition to its predicted role in regulation of pre-mRNA splicing, RSP-6 also appears to play a role in some aspect of transcription termination, as rsp-6(lf) suppresses the SynMuv phenotype of lin-15(n765), a complex mutation that includes transposition of the 3'end of another gene into lin-15B; an RSP-6::GFP fusion protein is expressed beginning at the 20-30-cell stage of embryogenesis and localizes to the nucleus. | Paper_evidence | WBPaper00003988 | |||||
WBPaper00004261 | |||||||||
WBPaper00032289 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 16 Oct 2009 00:00:00 | ||||||||
Automated_description | Predicted to enable mRNA binding activity. Involved in gonad development and regulation of termination of DNA-templated transcription. Located in nucleus. Expressed in several structures, including PVDL and PVDR. Human ortholog(s) of this gene implicated in bipolar disorder; clear cell renal cell carcinoma; and ovary epithelial cancer. Is an ortholog of human SRSF7 (serine and arginine rich splicing factor 7). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:4467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10789) | ||||
DOID:3312 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10785) | ||||||
DOID:2152 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10785) | ||||||
Molecular_info | Corresponding_CDS | C33H5.12a | |||||||
Corresponding_CDS_history | C33H5.12b:wp241 | ||||||||
C33H5.12c:wp241 | |||||||||
Corresponding_transcript | C33H5.12b | ||||||||
C33H5.12c | |||||||||
C33H5.12a.1 | |||||||||
Other_sequence (122) | |||||||||
Associated_feature | WBsf651953 | ||||||||
WBsf651954 | |||||||||
WBsf668056 | |||||||||
WBsf668057 | |||||||||
WBsf981789 | |||||||||
WBsf997047 | |||||||||
WBsf230330 | |||||||||
WBsf230331 | |||||||||
WBsf230332 | |||||||||
Experimental_info | RNAi_result (39) | ||||||||
Expr_pattern | Expr419 | ||||||||
Expr1139 | |||||||||
Expr12218 | |||||||||
Expr12229 | |||||||||
Expr1029228 | |||||||||
Expr1032323 | |||||||||
Expr1145822 | |||||||||
Expr2015563 | |||||||||
Expr2033798 | |||||||||
Drives_construct | WBCnstr00010100 | ||||||||
WBCnstr00020417 | |||||||||
Construct_product | WBCnstr00020472 | ||||||||
Microarray_results | SMD_C33H5.12 | ||||||||
192183_s_at | |||||||||
A_12_P107050 | |||||||||
A_12_P112157 | |||||||||
A_12_P115676 | |||||||||
A_12_P133137 | |||||||||
A_12_P133138 | |||||||||
A_12_P133139 | |||||||||
Aff_C33H5.12 | |||||||||
GPL13394_WBGene00004703 | |||||||||
GPL13914_C33H5.12 | |||||||||
GPL14144_C33H5.12a_192-251_0.533_12_B | |||||||||
GPL14144_C33H5.12a_61-120_0.556_11_A | |||||||||
GPL14144_C33H5.12a_84-143_0.452_22_C | |||||||||
GPL19516_CGZ0007349 | |||||||||
GPL19516_CGZ0007350 | |||||||||
GPL19516_CGZ0007351 | |||||||||
GPL19516_CGZ0007352 | |||||||||
GPL21109_C33H5.12a | |||||||||
GPL21109_C33H5.12b.1 | |||||||||
GPL21109_C33H5.12b.2 | |||||||||
GPL3518_CE04155 | |||||||||
GPL3518_CE29697 | |||||||||
GPL3518_CE29698 | |||||||||
GPL8304_CE_WBGene00004703_A | |||||||||
GPL8673_C33H5_12aP00284 | |||||||||
GPL8673_C33H5_12aP00331 | |||||||||
GPL8673_C33H5_12aP00451 | |||||||||
GPL8673_C33H5_12bP00379 | |||||||||
GPL8673_C33H5_12cP00001 | |||||||||
GPL8673_C33H5_12cP00105 | |||||||||
GPL8673_C33H5_12cP00151 | |||||||||
GPL9450_C33H5.12a | |||||||||
GPL9450_C33H5.12b | |||||||||
GPL9450_C33H5.12c | |||||||||
cea2.d.01152 | |||||||||
cea2.d.07794 | |||||||||
cea2.d.15349 | |||||||||
cea2.d.15351 | |||||||||
Expression_cluster (155) | |||||||||
Interaction (116) | |||||||||
Map_info | Map | IV | Position | 3.48318 | Error | 0.001119 | |||
Positive | Positive_clone | C33H5 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Mapping_data | Multi_point | 4464 | |||||||
4649 | |||||||||
4935 | |||||||||
Pseudo_map_position | |||||||||
Reference (15) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |