Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00000445

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00000445SMapS_parentSequenceF29F11
IdentityVersion2
NameCGC_nameceh-22Person_evidenceWBPerson83
Sequence_nameF29F11.5
Molecular_name (15)
Other_namesys-3Paper_evidenceWBPaper00027082
Person_evidenceWBPerson320
CELE_F29F11.5Accession_evidenceNDBBX284605
Public_nameceh-22
DB_infoDatabaseWormQTLgeneWBGene00000445
SignaLinkproteinWBGene00000445
WormFluxgeneWBGene00000445
NDBlocus_tagCELE_F29F11.5
PanthergeneCAEEL|WormBase=WBGene00000445|UniProtKB=P41936
familyPTHR24340
NCBIgene179485
RefSeqproteinNM_001083274.3
NM_001356739.4
NM_001083275.4
NM_001083273.4
NM_001356738.3
SwissProtUniProtAccP41936
TrEMBLUniProtAccA0A2C9C3N2
A0A2C9C312
UniProt_GCRPUniProtAccP41936
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
204 Dec 2006 14:52:18WBPerson1847EventAcquires_mergeWBGene00007040
Name_changeOther_namesys-3
Acquires_mergeWBGene00007040
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classceh
Reference_alleleWBVar00239183
Allele (54)
Legacy_informationcc8266te : pharyngeal defects, poor feeding, some larval arrest. OA1: pk40tci Encodes protein related (83%) to NK-2 of Drosophila. Candidate binding protein for myo-2 enhancer. ceh-22:lacZ expressed in pharyngeal muscle. [Okkema and Fire 1994]
[C.elegansII] cc8266te : pharyngeal defects, poor feeding, some larval arrest. OA1: pk40tci Encodes protein related (83%) to NK-2 of Drosophila.Candidate binding protein for myo-2 enhancer. ceh-22:lacZ expressed in pharyngeal muscle. [Okkema and Fire 1994]
StrainWBStrain00029938
WBStrain00029950
WBStrain00030611
WBStrain00002782
WBStrain00022585
WBStrain00022629
WBStrain00030612
WBStrain00029939
WBStrain00049270
RNASeq_FPKM (74)
GO_annotation (22)
Ortholog (35)
ParalogWBGene00000428Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000434Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000447Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00000584Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000449Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000450Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionceh-22 encodes an NK-2 family homeodomain factor homologous to Drosophila TINMAN and vertebrate Nkx2-5 proteins; CEH-22 activates pharyngeal muscle gene expression in combination with PHA-1 and is required for normal pharyngeal development; ceh-22 is the first gene known to be expressed in pharyngeal muscles, being exclusively active in that tissue.Paper_evidenceWBPaper00005167
WBPaper00002925
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated15 Feb 2014 00:00:00
Automated_descriptionEnables sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; pharyngeal muscle development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including G1; gonad; neurons; pharyngeal cell; and ventral nerve cord. Used to study cancer. Is an ortholog of human NKX2-2 (NK2 homeobox 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:162Homo sapiensPaper_evidenceWBPaper00060633
Curator_confirmedWBPerson324
Date_last_updated24 Jun 2021 00:00:00
Models_disease_assertedWBDOannot00000949
WBDOannot00000954
WBDOannot00000961
WBDOannot00000962
Molecular_infoCorresponding_CDSF29F11.5a
F29F11.5b
F29F11.5c
F29F11.5d
F29F11.5e
Corresponding_transcriptF29F11.5a.1
F29F11.5b.1
F29F11.5c.1
F29F11.5d.1
F29F11.5e.1
Other_sequenceAcan_isotig04736
Oden_isotig21208
CBC02288_1
MI05158
MIC04433_1
JI177847.1
Associated_feature (24)
Gene_product_binds (135)
Transcription_factorWBTranscriptionFactor000061
Experimental_infoRNAi_resultWBRNAi00071562Inferred_automaticallyRNAi_primary
WBRNAi00014111Inferred_automaticallyRNAi_primary
WBRNAi00031582Inferred_automaticallyRNAi_primary
WBRNAi00115657Inferred_automaticallyRNAi_primary
WBRNAi00027310Inferred_automaticallyRNAi_primary
WBRNAi00069884Inferred_automaticallyRNAi_primary
WBRNAi00025316Inferred_automaticallyRNAi_primary
WBRNAi00045934Inferred_automaticallyRNAi_primary
Expr_pattern (23)
Drives_construct (18)
Construct_product (13)
AntibodyWBAntibody00000082
WBAntibody00000083
Microarray_results (30)
Expression_cluster (133)
InteractionWBInteraction000000537
WBInteraction000002369
WBInteraction000002374
WBInteraction000003154
WBInteraction000003178
WBInteraction000003860
WBInteraction000005789
WBInteraction000028384
WBInteraction000028570
WBInteraction000030084
WBInteraction000034756
WBInteraction000035997
WBInteraction000037348
WBInteraction000037588
WBInteraction000038310
WBInteraction000038311
WBInteraction000038312
WBInteraction000038646
WBInteraction000038647
WBInteraction000038648
WBInteraction000039925
WBInteraction000041817
WBInteraction000042735
WBInteraction000043414
WBInteraction000043491
WBInteraction000043713
WBInteraction000044820
WBInteraction000045927
WBInteraction000046128
WBInteraction000046553
WBInteraction000047719
WBInteraction000049078
WBInteraction000049737
WBInteraction000052005
WBInteraction000052006
WBInteraction000052007
WBInteraction000052008
WBInteraction000052009
WBInteraction000126090
WBInteraction000126396
WBInteraction000126594
WBInteraction000161822
WBInteraction000161823
WBInteraction000165546
WBInteraction000169427
WBInteraction000173926
WBInteraction000229579
WBInteraction000229695
WBInteraction000239608
WBInteraction000263399
WBInteraction000264788
WBInteraction000274567
WBInteraction000291489
WBInteraction000315668
WBInteraction000329333
WBInteraction000329508
WBInteraction000340426
WBInteraction000349683
WBInteraction000351765
WBInteraction000354743
WBInteraction000364703
WBInteraction000366401
WBInteraction000372050
WBInteraction000378654
WBInteraction000385972
WBInteraction000387597
WBInteraction000388951
WBInteraction000396096
WBInteraction000413329
WBInteraction000414335
WBInteraction000417703
WBInteraction000427625
WBInteraction000436303
WBInteraction000441752
WBInteraction000501543
WBInteraction000501567
WBInteraction000502315
WBInteraction000502316
WBInteraction000502645
WBInteraction000502821
WBInteraction000502822
WBInteraction000503977
WBInteraction000520433
WBInteraction000520954
WBInteraction000521670
WBInteraction000521702
WBInteraction000521703
WBInteraction000521704
WBInteraction000521705
WBInteraction000521706
WBInteraction000521736
WBInteraction000521737
WBInteraction000521738
WBInteraction000524106
WBInteraction000525588
WBInteraction000525589
WBInteraction000525590
WBInteraction000525591
WBInteraction000525592
WBInteraction000525593
WBInteraction000525594
WBInteraction000525595
WBInteraction000528918
WBInteraction000529591
WBInteraction000534642
WBInteraction000534711
WBInteraction000538592
WBInteraction000538596
WBInteraction000538601
WBInteraction000538606
WBInteraction000541817
WBProcessWBbiopr:00000073
WBbiopr:00000114
Map_infoMapVPosition2.70908Error0.00321
Well_ordered
PositivePositive_cloneF29F11Inferred_automaticallyFrom sequence, transcript, pseudogene data
Y24E3
Y33F10
Y59H10
Y61D5
Mapping_dataMulti_point3789
Pos_neg_data8351
8352
8353
8354
8355
Reference (88)
MethodGene