n199mat : XX daughters of n199/+ mothers are maternally rescued weak dumpy phenotype with protruding vulva (ES2) 4% Him; XX daughters of n199/n199 mothers are severely dumpy and Him (2% of brood) or die as embryos or young larvae (98% of XX brood). XO n199 animals are non-dumpy almost wildtype males (ME3). Similar or slightly stronger phenotypes in n199/Df. NA3 (n198 (resembles n199) y6 (weaker phenotypes).
See also n198, n199, y6
[C.elegansII] n199mat : XX daughters of n199/+ mothers are maternally rescued weak dumpy phenotype with protruding vulva (ES2) 4% Him; XX daughters of n199/n199 mothers are severely dumpy and Him (2% of brood) or die as embryos or young larvae (98% of XX brood). XO n199 animals are non-dumpy almost wildtype males (ME3). Similar or slightly stronger phenotypes in n199/Df. OA3: n198 (resembles n199), y6 (weaker phenotypes), y65. Cloned: encodes predicted 1263 aa novel protein; antibody staining indicates DPY-26 associated with X chromosomes in XX, diffuse nuclear in XO. [Plenefisch et al. 1989; TY]
dpy-26 encodes a novel, acidic protein that is highly conserved in other Caenorhabditis species; during development, dpy-26 activity is required for both dosage compensation and meiotic chromosome segregation; DPY-26 localizes to all meiotic chromosomes in the germline and to the hermaphrodite X chromosomes in somatic cells; SDC-1, SDC-2, and SDC-3 proteins form a complex and these three proteins, in turn, colocalize with DPY-26, DPY-27, and MIX-1 proteins both on the X chromosome and on a transgenic her-1(+) array.
Involved in dosage compensation by hypoactivation of X chromosome; meiotic sister chromatid segregation; and mitotic sister chromatid segregation. Located in condensed nuclear chromosome. Part of dosage compensation complex. Expressed widely.