WormBase Tree Display for Gene: WBGene00016204
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WBGene00016204 | SMap | S_parent | Sequence | C29E4 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | gsto | ||||||
Allele (25) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00041808 | ||||||
00041809 | |||||||
00041810 | |||||||
00041811 | |||||||
00041812 | |||||||
00041813 | |||||||
00041814 | |||||||
00041815 | |||||||
00041816 | |||||||
00041817 | |||||||
00041818 | |||||||
00041819 | |||||||
00041820 | |||||||
00041821 | |||||||
00041822 | |||||||
00041823 | |||||||
00041824 | |||||||
00041825 | |||||||
00041826 | |||||||
00041827 | |||||||
00041828 | |||||||
00041829 | |||||||
00041830 | |||||||
00041831 | |||||||
00041832 | |||||||
00041833 | |||||||
00041834 | |||||||
00041835 | |||||||
00121884 | |||||||
00121885 | |||||||
Ortholog (39) | |||||||
Paralog | WBGene00001792 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00015337 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00043097 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00019636 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001365 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00001371 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00001790 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00001791 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00008920 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00021817 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | gsto-1 encodes an experimentally verified thiol oxidoreductase and dehydroascorbate reductase, required for normal stress resistance; formally, GSTO-1 is an omega-class glutathione transferase (GST; EC 2.5.1.18), but it has little activity in vitro on classic GST substrates; GSTO-1 is expressed in postembryonic intestine; gsto-1(RNAi) induces hypersensitivity to heat-, arsenite-, juglone-, paraquat-, or cumene hydroperoxide-induced stresses, whereas overexpression of GSTO-1 enhances resistance to them; gsto-1 transcription is upregulated by stress; ELT-2 may directly activate gsto-1 transcription in developing gut via a 300-nucleotide sequence upstream of gsto-1's ATG start site. | Paper_evidence | WBPaper00031042 | |||
WBPaper00031083 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 16 Oct 2007 00:00:00 | ||||||
Automated_description | Enables glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Involved in cellular response to extracellular stimulus; obsolete oxidation-reduction process; and response to superoxide. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Is an ortholog of human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13312,HGNC:23064) | ||
DOID:2841 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23064) | ||||
DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13312,HGNC:23064) | ||||
Molecular_info | Corresponding_CDS | C29E4.7 | |||||
Corresponding_transcript | C29E4.7.1 | ||||||
Other_sequence | CBC14472_1 | ||||||
AF203814.2 | |||||||
CJC05775_1 | |||||||
Associated_feature | WBsf034318 | ||||||
WBsf667116 | |||||||
WBsf227052 | |||||||
Experimental_info | RNAi_result (15) | ||||||
Expr_pattern | Expr4883 | ||||||
Expr4884 | |||||||
Expr1021261 | |||||||
Expr1036937 | |||||||
Expr1145482 | |||||||
Expr2012336 | |||||||
Expr2030573 | |||||||
Drives_construct | WBCnstr00012309 | ||||||
WBCnstr00028246 | |||||||
Construct_product | WBCnstr00012309 | ||||||
WBCnstr00028246 | |||||||
Antibody | WBAntibody00001308 | ||||||
Microarray_results (18) | |||||||
Expression_cluster (227) | |||||||
Interaction (15) | |||||||
Map_info | Map | III | Position | -0.473487 | Error | 0.00203 | |
Positive | Positive_clone | C29E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00024841 | ||||||
WBPaper00031042 | |||||||
WBPaper00038491 | |||||||
WBPaper00042271 | |||||||
WBPaper00045842 | |||||||
WBPaper00055090 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |