Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00022599

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00022599SMapS_parentSequenceZC395
IdentityVersion2
Name (5)
DB_infoDatabaseAceViewgene3G364
WormQTLgeneWBGene00022599
WormFluxgeneWBGene00022599
NDBlocus_tagCELE_ZC395.10
PanthergeneCAEEL|WormBase=WBGene00022599|UniProtKB=Q23280
familyPTHR22932
NCBIgene175727
RefSeqproteinNM_065725.5
SwissProtUniProtAccQ23280
TREEFAMTREEFAM_IDTF315077
UniProt_GCRPUniProtAccQ23280
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:06WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
221 Sep 2017 11:27:19WBPerson2970Name_changeCGC_namedaf-41
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classdaf
Allele (15)
StrainWBStrain00001518
WBStrain00032911
WBStrain00032936
WBStrain00037205
RNASeq_FPKM (74)
GO_annotation00077908
00077909
00077910
00077911
00077912
00077913
00077914
00126638
Contained_in_operonCEOP3276
Ortholog (42)
Structured_descriptionAutomated_descriptionPredicted to enable Hsp90 protein binding activity and protein-folding chaperone binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and protein folding. Located in myofibril. Expressed in several structures, including amphid neurons; anal depressor muscle; phasmid neurons; touch receptor neurons; and vulva. Human ortholog(s) of this gene implicated in atherosclerosis; breast cancer; and oligodendroglioma. Is an ortholog of human PTGES3 (prostaglandin E synthase 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:3181Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:16049)
DOID:1936Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:16049)
DOID:1612Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:16049)
Molecular_infoCorresponding_CDSZC395.10
Corresponding_transcriptZC395.10.1
Other_sequence (49)
Associated_featureWBsf651041
WBsf655434
WBsf226659
Experimental_infoRNAi_result (12)
Expr_pattern (12)
Drives_constructWBCnstr00002375
WBCnstr00004326
WBCnstr00024122
Construct_productWBCnstr00013931
WBCnstr00024122
WBCnstr00040348
Microarray_results (20)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00032528:L3_enriched
WBPaper00037047:aging_accelerated_insoluble_protein
WBPaper00037047:insoluble_protein
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038118:stress_upregulated_N2
WBPaper00040209:B.thuringiensis_downregulated_MY18
WBPaper00040420:FLP_enriched
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_downregulated
WBPaper00045774:clk-1_downregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048910:Apoptosis-induced_mRNA-interacting_protein
WBPaper00048910:mRNA-interacting_protein
WBPaper00048988:neuron_expressed
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050199:hsf-1(ok600)_downregulated
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050686:glp-1(e2141)_downregulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:body-wall-muscle_nucleus_expressed
WBPaper00051245:cytoplasm_specific
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053254:hsp-90(RNAi)_upregulated_protein
WBPaper00053289:DREAM-target
WBPaper00053388:dauer_regulated_Cluster5
WBPaper00053615:SMO-1_target
WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00053810:isp-1(qm150)_downregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00053814:25C_downregulated_OP50
WBPaper00053814:25C_downregulated_PY79
WBPaper00055049:S.gordonii_downregulated
WBPaper00055482:pmt-2(RNAi)_downregulated
WBPaper00055648:germline_expressed
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_downregulated_N2
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056284:ints-5(RNAi)_downregulated
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00056826:SGP_biased
WBPaper00056997:nmad-1(ok3133)_downregulated_germline_25C
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00060014:set-2(zr2012)_upregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061274:hypergravity_10xg_upregulated
WBPaper00061340:ASG
WBPaper00061340:ASG_AWA
WBPaper00061340:ASI
WBPaper00061340:ASI_parent
WBPaper00061340:AWC
WBPaper00061340:Neuroblast_ADE_ADA
WBPaper00061340:Neuroblast_ALM_BDU
WBPaper00061341:28C_24h_downregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061358:ferulic-acid_upregulated
WBPaper00061527:pbs-3_18439-rpn-5
WBPaper00061651:DB01_enriched
WBPaper00061651:Germline_enriched
WBPaper00061651:I4_enriched
WBPaper00061651:NSM_enriched
WBPaper00061651:PDE_enriched
WBPaper00062325:etr-1(lq61)_upregulated
WBPaper00062498:PPM-1.D_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064055:trl-1(cas1077)_downregulated_starved
WBPaper00064055:trl-1(cas1078)_upregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064163:ZNFX-1_interacting_embryo
WBPaper00064716:paraquat_upregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065149:lin-52(n771)_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4386_cluster_3_6
cgc4489_group_4
WBPaper00006465:II_ethanol_late_induction
WBPaper00025032:cluster_27
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00032948:FedUp
WBPaper00033101:spr-5_regulated
WBPaper00034739:N2moreDR1350
WBPaper00036123:Atrazine_regulated
WBPaper00038427:lin-54_embryo_changed
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_aging
WBPaper00040858:eQTL_regulated_reproductive
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00045673:colistin_downregulated
WBPaper00045960:L1-L4-lethargus_downregulated
WBPaper00045960:L4-lethargus_downregulated
WBPaper00048989:N2_allantoin_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:cluster_1
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MD_pd(23_min)
[cgc5767]:expression_class_SM
[cgc5767]:expression_class_SMD
[cgc6390]:oogenesis-enriched
Interaction (160)
Map_infoMapIIIPosition-1.84928
PositivePositive_cloneZC395Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (16)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene