WormBase Tree Display for Gene: WBGene00020094

WBGene00020094 SMap: S_parent: Sequence: R144
  Identity: Version: 2
    Name: CGC_name: wip-1 Person_evidence: WBPerson1949
      Sequence_name: R144.4
      Molecular_name (6)
      Other_name: CELE_R144.4 Accession_evidence: NDB BX284603
      Public_name: wip-1
    DB_info: Database: AceView gene 3G109
        WormQTL gene WBGene00020094
        WormFlux gene WBGene00020094
        NDB locus_tag CELE_R144.4
        NCBI gene 175681
        RefSeq protein NM_171863.4
            NM_171109.4
        TrEMBL UniProtAcc Q8WT46
            H2KZ22
        UniProt_GCRP UniProtAcc Q8WT46
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:02 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 22 Mar 2006 08:13:40 WBPerson2970 Name_change: CGC_name: wip-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: wip
    Allele (34)
    Strain: WBStrain00037056
      WBStrain00034756
    RNASeq_FPKM (74)
    GO_annotation: 00022028
      00022029
      00022030
      00022031
      00124805
    Contained_in_operon: CEOP3256
    Ortholog (33)
    Paralog: WBGene00006957 Caenorhabditis elegans From_analysis: Panther
      WBGene00007840 Caenorhabditis elegans From_analysis: Panther
      WBGene00015100 Caenorhabditis elegans From_analysis: Panther
      WBGene00015107 Caenorhabditis elegans From_analysis: Panther
      WBGene00011978 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: wip-1 encodes the C. elegans ortholog of WASP-interacting protein; wip-1 is required for embryonic morphogenesis, specifically ventral enclosure; WIP-1 is predicted to bind G-actin and in a yeast two-hybrid assay WIP-1 physically interacts with WSP-1, the C. elegans WASP ortholog; WIP-1 and WSP-1 are mutually required for normal protein levels; WIP-1 is broadly expressed in the embryo and is found in migrating hypodermal cells during ventral enclosure. Paper_evidence: WBPaper00027006
          Curator_confirmed: WBPerson1843
          Date_last_updated: 29 May 2013 00:00:00
      Automated_description: Enables cytoskeletal regulatory protein binding activity. Involved in embryonic body morphogenesis; regulation of cell migration; and regulation of protein stability. Expressed in hypodermis. Is an ortholog of human WIPF1 (WAS/WASL interacting protein family member 1); WIPF2 (WAS/WASL interacting protein family member 2); and WIPF3 (WAS/WASL interacting protein family member 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: R144.4a
      R144.4b
    Corresponding_CDS_history: R144.4a:wp102
      R144.4b:wp102
    Corresponding_transcript: R144.4a.1
      R144.4b.1
    Other_sequence: AS00801
      CRC00425_1
      NB08701
      CBC02684_1
      NBC07295_1
      Tcol_contig19598
      JO475789.1
      ASC23400_1
    Associated_feature: WBsf981465
      WBsf992270
      WBsf992271
      WBsf1014827
      WBsf1014828
      WBsf224836
      WBsf224837
  Experimental_info: RNAi_result (24)
    Expr_pattern: Expr4343
      Expr1019444
      Expr1038733
      Expr1155604
      Expr1200206
      Expr2018069
      Expr2036207
    Drives_construct: WBCnstr00025376
    Construct_product: WBCnstr00025376
    Antibody: WBAntibody00001047
    Microarray_results (31)
    Expression_cluster: WBPaper00032097:CGH-1-associated-mRNA
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_8
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPS_downregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F1_morc-1(tm6048)_downregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056617:adr-1(gv6)_downregulated_embryo_protein
      WBPaper00056617:adr-1(tm668)_downregulated_embryo_protein
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058942:henn-1(pk2295)_downregulated
      WBPaper00059194:KLF-1_interacting
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00061340:g2_parent
      WBPaper00061340:Rectal_cell
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061466:nath-10(icb99)_downregulated
      WBPaper00061527:dld-1-skn-1_16701
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065158:AFD_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00034739:N2lessDR1350
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035905:FBF-1_Associated
      WBPaper00037611:GLD-2-associated
      WBPaper00037611:RNP-8-associated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040821:Au-NP_regulated
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00056330:mrps-5(RNAi)_downregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(53_min)
    Interaction (63)
  Map_info: Map: III Position: -2.22895 Error: 0.003422
    Positive: Positive_clone: R144 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027006
    WBPaper00031805
    WBPaper00038491
    WBPaper00040857
    WBPaper00055090
    WBPaper00056797
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene