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WormBase Tree Display for Gene: WBGene00019126

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Name Class

WBGene00019126SMapS_parentSequenceF59E12
IdentityVersion3
NameCGC_namesam-4Paper_evidenceWBPaper00045884
Person_evidenceWBPerson451
Sequence_nameF59E12.11
Molecular_nameF59E12.11
F59E12.11.1
CE28570
F59E12.11.2
Other_nameF59E12.dCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
F59E12.cCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
F59E12.nCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_F59E12.11Accession_evidenceNDBBX284602
Public_namesam-4
DB_infoDatabaseAceViewgene2F938
WormQTLgeneWBGene00019126
WormFluxgeneWBGene00019126
NDBlocus_tagCELE_F59E12.11
PanthergeneCAEEL|EnsemblGenome=WBGene00019126|UniProtKB=O01902
familyPTHR31634
NCBIgene173955
RefSeqproteinNM_001381430.3
TREEFAMTREEFAM_IDTF316379
TrEMBLUniProtAccO01902
UniProt_GCRPUniProtAccO01902
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:01WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
212 Nov 2014 15:10:23WBPerson2970Name_changeCGC_namesam-4
306 Mar 2018 14:46:54WBPerson4025EventSplit_intoWBGene00302971
Split_intoWBGene00302971
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsam
Allele (24)
RNASeq_FPKM (74)
GO_annotation (16)
Contained_in_operonCEOP2198
CEOP5593
Ortholog (33)
Structured_descriptionConcise_descriptionsam-4 encodes a novel protein orthologous to human LOH12CR1, deletions of which have been associated with acute lymphoblastic leukemia; SAM-4 activity is required cell autonomously to maintain synaptic vesicle transport processivity; in regulating synaptic vesicle tranport, SAM-4 functions together with the UNC-104 kinesin motor protein and SYD-2/liprin-alpha; SAM-4 is broadly expressed in the nervous system where it localizes primarily to the anterior nerve ring and, subcellularly, to synaptic vesicle membranes.Paper_evidenceWBPaper00045884
Curator_confirmedWBPerson1843
Date_last_updated12 Dec 2014 00:00:00
Automated_descriptionEnables guanyl-nucleotide exchange factor activity. Involved in several processes, including multicellular organismal reproductive process; positive regulation of anterograde synaptic vesicle transport; and positive regulation of pharyngeal pumping. Located in synaptic vesicle membrane. Expressed in nerve ring. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Is an ortholog of human BORCS5 (BLOC-1 related complex subunit 5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050861Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17950)
Molecular_infoCorresponding_CDSF59E12.11
Corresponding_CDS_historyF59E12.11a:wp264
F59E12.11b:wp264
Corresponding_transcript (2)
Corresponding_transcript_historyF59E12.11c:wp264
Other_sequenceEY463123.1
CJC12832_1
CBC16884_1
Associated_featureWBsf650074
WBsf650075
WBsf650076
WBsf223077
Experimental_infoRNAi_result (20)
Expr_patternExpr12013
Expr1010547
Expr1038256
Expr1152947
Expr2015584
Expr2033819
Drives_constructWBCnstr00019746
WBCnstr00019749
WBCnstr00026043
Construct_productWBCnstr00019745
WBCnstr00019746
WBCnstr00019747
WBCnstr00019749
WBCnstr00026043
Microarray_results (19)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00035269:cde-1_regulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037946:LIN-39_interacting
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044760:germline_specific
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045521:Gender_Neutral
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053289:DREAM-target
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
WBPaper00053810:clk-1(qm30)_downregulated
WBPaper00055648:germline_expressed
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056826:SGP_biased
WBPaper00057288:Cold_downregulated_transcript
WBPaper00059471:EGL-43_interacting
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00061274:hypergravity_15xg_upregulated
WBPaper00061527:pch-2-B0393.3
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064716:paraquat_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065373:sek-1(km4)_upregulated_Ref
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4489_group_2
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00030985:Serratia_marcesens_upregulated
WBPaper00031252:AIN-2_IP_enriched
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00035905:FBF-1_Associated
WBPaper00036286:Pattern_F
WBPaper00037147:heatshock_upregulated
WBPaper00038060:SUMO-1_upregulated
WBPaper00040210:Diazinon_24C_regulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_juvenile
WBPaper00040963:TA300_down
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
[cgc6390]:Cluster_E
[cgc6390]:oogenesis-enriched
Interaction (44)
Map_infoMapIIPosition-0.993749
PositivePositive_cloneF59E12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00035228
WBPaper00038491
WBPaper00045884
WBPaper00052655
WBPaper00052935
WBPaper00055090
WBPaper00064980
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene