sam-4 encodes a novel protein orthologous to human LOH12CR1, deletions of which have been associated with acute lymphoblastic leukemia; SAM-4 activity is required cell autonomously to maintain synaptic vesicle transport processivity; in regulating synaptic vesicle tranport, SAM-4 functions together with the UNC-104 kinesin motor protein and SYD-2/liprin-alpha; SAM-4 is broadly expressed in the nervous system where it localizes primarily to the anterior nerve ring and, subcellularly, to synaptic vesicle membranes.
Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including multicellular organismal reproductive process; positive regulation of anterograde synaptic vesicle transport; and positive regulation of pharyngeal pumping. Located in synaptic vesicle membrane. Expressed in nerve ring. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Is an ortholog of human BORCS5 (BLOC-1 related complex subunit 5).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.