WormBase Tree Display for Gene: WBGene00018734

WBGene00018734 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 2
    Name: Sequence_name: F53A10.2
      Molecular_name (22)
      Other_name: CELE_F53A10.2 Accession_evidence: NDB BX284602
      Public_name: F53A10.2
    DB_info: Database: AceView gene 2B519
        WormQTL gene WBGene00018734
        WormFlux gene WBGene00018734
        NDB locus_tag CELE_F53A10.2
        Panther gene CAEEL|WormBase=WBGene00018734|UniProtKB=H2L055
          family PTHR15711
        NCBI gene 173502
        RefSeq protein NM_001322703.3
            NM_001322701.3
            NM_001393000.1
            NM_001393001.1
            NM_001322702.3
            NM_001027019.3
        TrEMBL UniProtAcc A0A131MBF2
            H2L055
            A0A131MCP2
            A0A131MBM3
            Q8IA84
            Q965M4
        UniProt_GCRP UniProtAcc H2L055
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 29 Nov 2004 17:10:33 WBPerson2970 Event: Acquires_merge: WBGene00018733
      Acquires_merge: WBGene00018733
    Status: Live
  Gene_info: Biotype: SO:0001217
    Allele (847)
    Strain: WBStrain00055198
    RNASeq_FPKM (74)
    GO_annotation: 00001998
      00001999
      00002000
      00022854
      00022855
      00123774
      00123775
      00123776
    Ortholog (41)
    Paralog: WBGene00012100 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: F53A10.2 encodes a Rap1GAP homolog; a region of F53A10.2 encompassing one GoLoco motif specifically binds GOA-1 in yeast two-hybrid assays, and also binds itself; F53A10.2 is expressed in hypodermal seam cells, various neurons, and intestinal cells; F53A10.2 has no obvious function or phenotype in RNAi assays, whether in a normal background or in goa-1(-) or goa-1(gf) mutant backgrounds. Paper_evidence: WBPaper00006194
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in cytoplasm. Expressed in intestine; neurons; and seam cell. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; endocrine gland cancer (multiple); and myelodysplastic syndrome. Is an ortholog of human RAP1GAP (RAP1 GTPase activating protein) and RAP1GAP2 (RAP1 GTPase activating protein 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3969 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9858)
      DOID:3312 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9858)
      DOID:0050908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9858)
      DOID:1909 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9858)
      DOID:1793 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9858)
      DOID:1312 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9858)
  Molecular_info: Corresponding_CDS: F53A10.2a
      F53A10.2b
      F53A10.2c
      F53A10.2d
      F53A10.2e
      F53A10.2f
    Corresponding_transcript: F53A10.2a.1
      F53A10.2b.1
      F53A10.2b.2
      F53A10.2b.3
      F53A10.2b.4
      F53A10.2b.5
      F53A10.2c.1
      F53A10.2d.1
      F53A10.2e.1
      F53A10.2f.1
    Other_sequence (48)
    Associated_feature (40)
  Experimental_info: RNAi_result: WBRNAi00032647 Inferred_automatically: RNAi_primary
      WBRNAi00063378 Inferred_automatically: RNAi_primary
      WBRNAi00015207 Inferred_automatically: RNAi_primary
      WBRNAi00063366 Inferred_automatically: RNAi_primary
      WBRNAi00020851 Inferred_automatically: RNAi_primary
      WBRNAi00032648 Inferred_automatically: RNAi_primary
      WBRNAi00048037 Inferred_automatically: RNAi_primary
      WBRNAi00015447 Inferred_automatically: RNAi_primary
      WBRNAi00048036 Inferred_automatically: RNAi_primary
      WBRNAi00048038 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2756
      Expr1015564
      Expr1038064
      Expr1151853
      Expr2004017
      Expr2022239
    Drives_construct: WBCnstr00010936
    Construct_product: WBCnstr00010936
    Microarray_results (40)
    Expression_cluster: WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00040412:germline-regulated_daf-16_target
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00046121:mesoderm_unique
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:let-418(n3536)_downregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061340:AMso
      WBPaper00061340:Anterior_arcade_cell
      WBPaper00061340:Glia
      WBPaper00061340:hyp1_hyp2
      WBPaper00061340:hyp3
      WBPaper00061340:mc1
      WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3
      WBPaper00061340:PVP
      WBPaper00061340:Tail_hypodermis
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:srj-42-srw-113
      WBPaper00061527:syd-1_2945-unc-41_2170
      WBPaper00061651:AVF_enriched
      WBPaper00061651:AVJ_enriched
      WBPaper00061651:RIG_enriched
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_8
      cgc4489_group_20
      WBPaper00025032:cluster_73
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00036286:Pattern_D
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00042274:tbx-2(bx59)_downregulated
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00045263:isp-1(qm150)_upregulated
      [cgc5376]:let-60(G12V)-regulated_genes
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (40)
  Map_info: Positive: Positive_clone: F53A10 Inferred_automatically: From sequence, transcript, pseudogene data
    Interpolated_map_position: II -15.5618
  Reference (3)
  Method: Gene