WormBase Tree Display for Gene: WBGene00018635

WBGene00018635 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 3
    Name: CGC_name: nprl-2 Person_evidence: WBPerson237
      Sequence_name: F49E8.1
      Molecular_name: F49E8.1a
        F49E8.1a.1
        CE33650
        F49E8.1b
        CE51825
        F49E8.1b.1
      Other_name: CELE_F49E8.1 Accession_evidence: NDB BX284604
      Public_name: nprl-2
    DB_info: Database: AceView gene 4I323
        WormQTL gene WBGene00018635
        WormFlux gene WBGene00018635
        NDB locus_tag CELE_F49E8.1
        Panther gene CAEEL|WormBase=WBGene00018635|UniProtKB=W6RQZ3
          family PTHR12991
        NCBI gene 177532
        RefSeq protein NM_001392334.1
            NM_001392333.1
        TrEMBL UniProtAcc W6SBD7
            W6RQZ3
        UniProt_GCRP UniProtAcc W6RQZ3
        OMIM gene 607072
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 11 Apr 2012 13:49:30 WBPerson2970 Name_change: CGC_name: nprl-2
        3 06 Mar 2018 14:46:01 WBPerson4025 Event: Split_into: WBGene00302976
      Split_into: WBGene00302976
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nprl
    Allele (33)
    RNASeq_FPKM (74)
    GO_annotation: 00105446
      00105447
      00105448
      00105449
      00105450
      00105451
      00105452
    Contained_in_operon: CEOP5598
    Ortholog (40)
    Structured_description: Automated_description: Predicted to contribute to GTPase activator activity. Predicted to be involved in cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of autophagy. Predicted to be located in vacuolar membrane. Predicted to be part of GATOR1 complex. Human ortholog(s) of this gene implicated in focal epilepsy. Is an ortholog of human NPRL2 (NPR2 like, GATOR1 complex subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:2234 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:24969)
  Molecular_info: Corresponding_CDS: F49E8.1a
      F49E8.1b
    Corresponding_CDS_history: F49E8.1:wp97
      F49E8.1:wp241
      F49E8.1a:wp256
      F49E8.1b:wp256
      F49E8.1c:wp264
    Corresponding_transcript: F49E8.1a.1
      F49E8.1b.1
    Other_sequence (24)
    Associated_feature (6)
  Experimental_info: RNAi_result: WBRNAi00061819 Inferred_automatically: RNAi_primary
      WBRNAi00032550 Inferred_automatically: RNAi_primary
      WBRNAi00015331 Inferred_automatically: RNAi_primary
      WBRNAi00047868 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1019604
      Expr1038019
      Expr1151698
      Expr2014430
      Expr2032671
    Drives_construct: WBCnstr00026371
    Construct_product: WBCnstr00026371
    Microarray_results (22)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00035211:age-1_vs_age-1_downregulated
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00051039:germline_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061340:Parent_of_PVP_and_rect_V
      WBPaper00061527:let-99_22239-such-1
      WBPaper00061527:T02E1.2-uri-1
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_3
      WBPaper00025032:cluster_94
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00029437:dcr-1_downregulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_F
      WBPaper00037147:heatshock_upregulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00041002:HF_3d_0.2mM_Down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(143_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:oogenesis-enriched
    Interaction (35)
  Map_info: Map: IV Position: 3.35571
    Positive: Positive_clone: F49E8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00042436
    WBPaper00052740
    WBPaper00055090
    WBPaper00055173
    WBPaper00061251
    WBPaper00064505
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene