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WormBase Tree Display for Gene: WBGene00017082

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Name Class

WBGene00017082SMapS_parentSequenceDC2
IdentityVersion1
NameSequence_nameDC2.5
Molecular_nameDC2.5a
DC2.5a.1
CE42420
DC2.5b
Other_nameCELE_DC2.5Accession_evidenceNDBBX284605
Public_nameDC2.5
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:30:58WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
StatusLive
Gene_infoBiotypeSO:0001217
Allele (48)
RNASeq_FPKM (74)
GO_annotation00100722
Ortholog (33)
Paralog (11)
Structured_descriptionAutomated_descriptionEnriched in several structures, including ABplpppapa; ABprpppapa; anal sphincter muscle; rectal epithelial cell; and sensory neurons based on RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including daf-16; daf-2; and skn-1 based on microarray; RNA-seq; and proteomic studies. Is affected by eighteen chemicals including TPEN; Alovudine; and stavudine based on RNA-seq; proteomic; and microarray studies. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; and esophagus squamous cell carcinoma. Human WWOX enables enzyme binding activity and identical protein binding activity. Is predicted to encode a protein with the following domains: Short-chain dehydrogenase/reductase SDR; short chain dehydrogenase; and NAD(P)-binding domain superfamily. Is an ortholog of human WWOX (WW domain containing oxidoreductase).Paper_evidenceWBPaper00065943
Curator_confirmed (2)
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:3748Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12799)
DOID:5041Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12799)
DOID:0080452Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12799)
DOID:0080060Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12799)
DOID:1749Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12799)
Molecular_infoCorresponding_CDSDC2.5a
Corresponding_CDS_historyDC2.5:wp88
DC2.5:wp125
DC2.5:wp188
Corresponding_transcriptDC2.5b
DC2.5a.1
Other_sequenceOden_isotig21742
Associated_featureWBsf652436
WBsf668708
WBsf999097
WBsf999098
WBsf999099
WBsf1019030
WBsf1019031
WBsf233243
Experimental_infoRNAi_resultWBRNAi00043540Inferred_automaticallyRNAi_primary
WBRNAi00012615Inferred_automaticallyRNAi_primary
Expr_patternExpr1025881
Expr1037341
Expr1147532
Expr2002107
Expr2020332
Microarray_results (15)
Expression_clusterWBPaper00033065:clk-1(qm30)_upregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038237:age-1_upregulated_intestine_rescue
WBPaper00038237:age-1_upregulated_neuron_rescue
WBPaper00038237:age-1_upregulated_nontransgenic
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040990:PA14_upregulated
WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
WBPaper00042561:smg-2(RNAi)_upregulated
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00044037:eat-2_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:oscillating_dev_expression
WBPaper00045390:ubc-9(RNAi)_upregulated
WBPaper00045774:clk-1_upregulated
WBPaper00046012:tdp-1(ok803)_upregulated
WBPaper00046887:WNT-target
WBPaper00047131:daf-2(e1370)_downregulated_N2-background
WBPaper00048988:neuron_expressed
WBPaper00049217:TCER-1_upregulated
WBPaper00049334:CE_intestine_enriched
WBPaper00049498:npr-1(ur89)_regulated_6
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00050121:mir-60(n4947)_upregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050412:cco-1(RNAi)_upregulated_N2
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050801:DPY-21_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:pharynx_enriched
WBPaper00050990:pharynx_expressed
WBPaper00051039:intestine_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051404:alg-1(gk214)_upregulated
WBPaper00051404:alg-2(ok304)_upregulated
WBPaper00051498:zinc-reduction_upregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:alovudine_72h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
WBPaper00053402:cco-1(RNAi)_upregulated
WBPaper00053599:female_vs_male_downregulated
WBPaper00053664:ins-11(tm1053)_downregulated
WBPaper00053810:clk-1(qm30)_upregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053810:sod-2(ok1030)_upregulated
WBPaper00054410:set-26(tm2467)_upregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00054872:egl-9(sa307)_downregulated
WBPaper00055013:hmg-3(bar24)_upregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Psora_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055386:daf-2(e1370)_downregulated
WBPaper00055827:pfd-6(gk493446)_upregulated
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00055941:nuo-6(qm200)_upregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056034:pals-25(jy9)_upregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_downregulated_N2
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056290:mdt-15(mg584)_upregulated
WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056586:mpk-2(ok219)_upregulated
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00056826:SGP_biased
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00057265:metaformin_upregulated_OP50
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00059194:klf-1(RNAi)_regulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059735:glucose_downregulated_lpin-1(RNAi)
WBPaper00059839:S.maltophilia_regulated
WBPaper00059895:wounding_downregulated
WBPaper00060014:set-2(zr2012)_downregulated
WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
WBPaper00060084:cco-1(RNAi)_upregulated_N2
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00060909:atfs-1(et18)_upregulated
WBPaper00061081:E.faecalis_downregulated_N2
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:B
WBPaper00061340:F_U
WBPaper00061340:G2_and_W_blasts
WBPaper00061340:mu_sph
WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
WBPaper00061340:P_cell
WBPaper00061340:T
WBPaper00061340:Y
WBPaper00061341:28C_48h_downregulated
WBPaper00061527:gst-26-pho-1_10767
WBPaper00061590:CGP37157_downregulated
WBPaper00061651:PHA_enriched
WBPaper00061651:PHB_enriched
WBPaper00061653:alh-4(hj221)_upregulated
WBPaper00061692:acivicin_upregulated
WBPaper00061699:daf-18(ok480)_upregulated
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062184:PA14_downregulated
WBPaper00062193:daf-16(RNAi)_upregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062237:dnj-21(RNAi)_upregulated_protein
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062440:crh-1(n3315)_upregulated
WBPaper00062456:doxycycline_upregulated_CB4856_protein
WBPaper00062590:Aging_downregulated_neuron
WBPaper00062606:rotenone_upregulated
WBPaper00062684:pathogen_downregulated_N2
WBPaper00064005:starvation_downregulated_N2_mRNA
WBPaper00064071:NHR-49_interacting
WBPaper00064158:xpo-1(RNAi)_upregulated
WBPaper00064532:pals-22(jy3)_upregulated
WBPaper00064539:nhr-114(gk849)_upregulated
WBPaper00064632:daf-2(e1370)_downregulated_intestine
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00065272:dhgd-1(tm6671)_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065373:sek-1(km4)_upregulated_Ref
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065841:1_1
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066085:sin-3(syb2172)_upregulated
WBPaper00066085:sin-3(tm1276)_upregulated
WBPaper00066110:Doxorubicin_upregulated_diploid
WBPaper00066204:CdCl2_upregulated_mRNA
WBPaper00066232:ash-2(RNAi)_downregulated_WT
cgc4489_group_20
WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
WBPaper00024671:AFD_vs_AWB_upregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026980:intestine_enriched
WBPaper00027758:Group_IV
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00031003:24hr_muscle_enriched
WBPaper00031003:total_muscle_enriched
WBPaper00032165:A_to_C_transit_increased
WBPaper00032165:differentially_expressed_with_age_medoid_2
WBPaper00034757:up_by_oxidative_stress
WBPaper00036286:Pattern_I
WBPaper00038172:crh-1null_up_regulated
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HF_11d_0.2mM_Up
WBPaper00041174:environmental
WBPaper00041174:genotypic
WBPaper00041174:genotypic_and_environmental
WBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00044091:Bpseudomallei_induced_8h
WBPaper00044091:Bpseudomallei_induced_12h
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00045437:Toxic-Se_upregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00050515:nipi-3(fr4)_upregulated
WBPaper00056330:mrps-5(RNAi)_upregulated
WBPaper00057098:SiO2-nanoparticles_downregulated
InteractionWBInteraction000471081
WBInteraction000585656
Map_infoPositivePositive_cloneDC2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Interpolated_map_positionV-20.0099
ReferenceWBPaper00038491
WBPaper00055090
MethodGene