WormBase Tree Display for Gene: WBGene00016768

WBGene00016768 SMap: S_parent: Sequence: C49C8
  Identity: Version: 2
    Name: CGC_name: cyp-33E1
      Sequence_name: C49C8.4
      Molecular_name: C49C8.4
        C49C8.4.1
        CE31452
        C49C8.4.2
      Other_name: CELE_C49C8.4 Accession_evidence: NDB BX284604
      Public_name: cyp-33E1
    DB_info: Database: AceView gene 4J410
        WormQTL gene WBGene00016768
        WormFlux gene WBGene00016768
        NDB locus_tag CELE_C49C8.4
        Panther gene CAEEL|WormBase=WBGene00016768|UniProtKB=Q27482
          family PTHR24300
        NCBI gene 183602
        RefSeq protein NM_069079.6
        TrEMBL UniProtAcc Q27482
        UniProt_GCRP UniProtAcc Q27482
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-33E1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (51)
    Strain: WBStrain00031731
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (75)
    Paralog (44)
    Structured_description: Automated_description: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; human immunodeficiency virus infectious disease; and renal hypertension. Is an ortholog of several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2C8 (cytochrome P450 family 2 subfamily C member 8); and CYP2F1 (cytochrome P450 family 2 subfamily F member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9974 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2615)
      DOID:783 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2622)
      DOID:1073 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2622)
      DOID:9828 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2615)
      DOID:9976 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2615)
      DOID:399 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2615)
      DOID:0050742 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2615)
      DOID:526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2615)
      DOID:9119 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2615)
  Molecular_info: Corresponding_CDS: C49C8.4
    Corresponding_CDS_history: C49C8.4:wp82
    Corresponding_transcript: C49C8.4.1
      C49C8.4.2
    Other_sequence (14)
    Associated_feature: WBsf652007
      WBsf1017868
      WBsf230446
  Experimental_info: RNAi_result: WBRNAi00012135 Inferred_automatically: RNAi_primary
      WBRNAi00029976 Inferred_automatically: RNAi_primary
      WBRNAi00090636 Inferred_automatically: RNAi_primary
      WBRNAi00012134 Inferred_automatically: RNAi_primary
      WBRNAi00092668 Inferred_automatically: RNAi_primary
      WBRNAi00042792 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8191
      Expr1028716
      Expr1146775
      Expr2010723
      Expr2028961
    Drives_construct: WBCnstr00004997
      WBCnstr00027817
    Construct_product: WBCnstr00027817
    Antibody: WBAntibody00002185
      WBAntibody00002224
    Microarray_results (17)
    Expression_cluster: WBPaper00004966:beta-Naphthoflavone_induced
      WBPaper00031040:Cluster_5
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045618:fbf-1_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:hypergravity_15xg_downregulated
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:nhr-18-C34D1.4_6256
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065288:mdt-15(tm2182)_upregulated
      WBPaper00065841:21_1
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_8
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028482:PA14_upregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp2
      WBPaper00035479:daf-16(RNAi)_downregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_I
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc6390]:Cluster_B
    Interaction (40)
  Map_info: Map: IV Position: 3.92656 Error: 0.001619
    Positive: Positive_clone: C49C8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4874
    Pseudo_map_position
  Reference (8)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene