| WBGene00016103 | SMap | S_parent | Sequence | C25F6 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | dpyd-1 |
| | | Sequence_name | C25F6.3 |
| | | Molecular_name | C25F6.3 |
| | | | C25F6.3.1 |
| | | | CE38489 |
| | | Other_name | CELE_C25F6.3 | Accession_evidence | NDB | BX284606 |
| | | Public_name | dpyd-1 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:30:57 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 03 Aug 2007 17:23:44 | WBPerson2970 | Name_change | CGC_name | dpyd-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | dpyd |
| | Allele (67) |
| | Strain | WBStrain00037841 |
| | RNASeq_FPKM (74) |
| | GO_annotation (23) |
| | Ortholog (32) |
| | Paralog | WBGene00012326 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00013376 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00020932 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | dpyd-1 encodes the C. elegans ortholog of human DihydroPYrimidine Dehydrogenase (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270); DPYD-1 is the first and rate-limiting enzyme for uracil and thymine metabolism to 5,6-dihydrouracil and 5,6-dihydrothymine, respectively, and in humans, functions in metabolism of the anti-cancer pyrimidine antagonist 5-fluorouracil (5-FU); in C. elegans, loss of dpyd-1 activity via RNAi results in sensitivity (decreased survival) to 5-FU while conversely, DPYD-1 overexpression affords increased germ cell survivability to 5-FU. | Paper_evidence | WBPaper00004637 |
| | | | | | WBPaper00013017 |
| | | | | | WBPaper00031988 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson1823 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 10 Jul 2008 00:00:00 |
| | | Automated_description | Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and gallbladder cancer. Is an ortholog of human DPYD (dihydropyrimidine dehydrogenase). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:9952 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3012) |
| | | DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3012) |
| | | DOID:14218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3012) |
| | | DOID:3121 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3012) |
| Molecular_info | Corresponding_CDS | C25F6.3 |
| | Corresponding_CDS_history | C25F6.3:wp142 |
| | Corresponding_transcript | C25F6.3.1 |
| | Other_sequence (74) |
| | Associated_feature | WBsf655176 |
| | | WBsf662790 |
| | | WBsf1005274 |
| | | WBsf1022956 |
| | | WBsf235726 |
| | | WBsf235727 |
| | | WBsf235728 |
| Experimental_info | RNAi_result | WBRNAi00041194 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1024901 |
| | | Expr1036877 |
| | | Expr1145225 |
| | | Expr2011080 |
| | | Expr2029317 |
| | Drives_construct | WBCnstr00028324 |
| | Construct_product | WBCnstr00028324 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00005700:transmembrane_protein |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00032976:non_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_embryo_enriched |
| | | WBPaper00037950:intestine_embryo_SelectivelyEnriched |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY18 |
| | | WBPaper00040209:B.thuringiensis_downregulated_N2 |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044005:DAF-16_downregulated |
| | | WBPaper00044128:daf-2(e1370)_downregulated |
| | | WBPaper00044128:DietaryRestriction_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_downregulated_Day5 |
| | | WBPaper00044746:aging_downregulated_Day10 |
| | | WBPaper00045460:pept-1(lg601)_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045934:wrn-1(gk99)_downregulated |
| | | WBPaper00046303:P.aeruginosa_upregulated_protein |
| | | WBPaper00046337:monosomal_N2_vs_daf-2_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048785:heat-shock_downregulated |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048971:daf-16(mgDf50)_upregulated_L1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049018:swsn-2.2(RNAi)_upregulated |
| | | WBPaper00049217:TCER-1_downregulated |
| | | WBPaper00049368:daf-2(e1370)_downregulated |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00049954:BPA_downregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051021:4-bromodiphenyl-ether_downregulated |
| | | WBPaper00051039:ash-2(RNAi)_regulated_intestine |
| | | WBPaper00051039:intestine_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053814:25C_upregulated_PY79 |
| | | WBPaper00055827:daf-2(e1370)_downregulated |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1 |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4 |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_protein |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059604:fluvastatin_upregulated_dlk-1(km12) |
| | | WBPaper00059604:fluvastatin_upregulated_N2 |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059728:20ug_cholesterol_upregulated |
| | | WBPaper00059816:crh-1(n3315)_downrgulated |
| | | WBPaper00059895:wounding_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061274:hypergravity_15xg_downregulated |
| | | WBPaper00061340:Body_wall_muscle |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061527:dhs-28_22199-acs-14 |
| | | WBPaper00061818:AFD_enriched_protein |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_downregulated_N2 |
| | | WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13) |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064315:met-1(bn200)_downregulated_PGCs |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064871:hypoxia_upregulated_F1 |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00064952:Day10_vs_L4_downregulated_20C |
| | | WBPaper00064952:Day10_vs_L4_downregulated_25C |
| | | WBPaper00065086:JU1400_N.ausubeli_regulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065086:N2_N.ausubeli_regulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_25C |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:26_1 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00066085:hda-3(ok1991)_upregulated |
| | | cgc4489_group_3 |
| | | WBPaper00024393:strongly_regulated_dauer_genes |
| | | WBPaper00025032:cluster_2 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_6 |
| | | WBPaper00034757:down_by_oxidative_stress |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035873:osm-7_regulated |
| | | WBPaper00035873:osm-8_regulated |
| | | WBPaper00035873:osmotically_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00038231:Cry5B_1.5-fold_downregulated |
| | | WBPaper00038231:Cry5B_2-fold_downregulated |
| | | WBPaper00040184:hcf-1down_sir-2.1down_daf-2down |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040823:alg-1(gk214)_upregulated |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040963:TA300_up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041207:CE_dauer_down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042258:DA1877_upregulated_GravidAdult |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5976]:class_2 |
| | | [cgc6390]:Cluster_C |
| | Interaction (64) |
| Map_info | Map | X | Position | -5.27561 |
| | Positive | Positive_clone | C25F6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (9) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
