WormBase Tree Display for Gene: WBGene00015648

WBGene00015648 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 3
    Name: CGC_name: orai-1 Person_evidence: WBPerson1851
      Sequence_name: C09F5.2
      Molecular_name (7)
      Other_name: CELE_C09F5.2 Accession_evidence: NDB BX284603
      Public_name: orai-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:56 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 18 Jul 2006 14:35:12 WBPerson2970 Name_change: CGC_name: orai-1
        3 03 Nov 2008 13:42:45 WBPerson1867 Event: Acquires_merge: WBGene00021065
      Acquires_merge: WBGene00021065
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: orai
    Allele (179)
    Strain: WBStrain00002066
    RNASeq_FPKM (74)
    GO_annotation (16)
    Contained_in_operon: CEOP3859
    Ortholog (46)
    Structured_description: Concise_description: orai-1 encodes a calcium release activated calcium (CRAC) channel orthologous to the vertebrate ORAI family of proteins; ORAI-1 activity is required for normal levels of fertility and for store-operated calcium channel (SOCC) activity in intestinal epithelial cells; co-expression of ORAI-1 and STIM-1 in HEK293 cells results in large inwardly rectifying cation currents activated by endoplasmic reticulum calcium depletion; ORAI-1 is expressed in the gonad and in the intestine; in the intestine, ORAI-1 appears to localize to the apical and basal plasma membrane; in the spermatheca, ORAI-1 expression is consistent with localization to the basal plasma membrane. Paper_evidence: WBPaper00028994
          Curator_confirmed: WBPerson1843
          Date_last_updated: 21 May 2014 00:00:00
      Automated_description: Enables store-operated calcium channel activity. Involved in ovulation and store-operated calcium entry. Located in apical plasma membrane and basolateral plasma membrane. Part of voltage-gated calcium channel complex. Expressed in gonadal sheath cell; head; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Is an ortholog of human ORAI2 (ORAI calcium release-activated calcium modulator 2) and ORAI3 (ORAI calcium release-activated calcium modulator 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080686 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:25896)
      DOID:0111976 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:25896)
  Molecular_info: Corresponding_CDS: C09F5.2a
      C09F5.2b
    Corresponding_CDS_history: C09F5.2:wp194
    Corresponding_transcript: C09F5.2a.1
      C09F5.2a.2
      C09F5.2b.1
    Other_sequence (41)
    Associated_feature (13)
  Experimental_info: RNAi_result: WBRNAi00090597 Inferred_automatically: RNAi_primary
      WBRNAi00028729 Inferred_automatically: RNAi_primary
      WBRNAi00010525 Inferred_automatically: RNAi_primary
      WBRNAi00085731 Inferred_automatically: RNAi_primary
      WBRNAi00001126 Inferred_automatically: RNAi_primary
      WBRNAi00054897 Inferred_automatically: RNAi_primary
      WBRNAi00040207 Inferred_automatically: RNAi_primary
      WBRNAi00006596 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram2030
      Expr4783
      Expr5220
      Expr5221
      Expr1013330
      Expr1036702
      Expr1144278
      Expr2014632
      Expr2032865
    Drives_construct: WBCnstr00002229
      WBCnstr00004260
      WBCnstr00008590
      WBCnstr00012242
      WBCnstr00028687
    Construct_product: WBCnstr00008590
      WBCnstr00012242
      WBCnstr00028687
    Microarray_results (31)
    Expression_cluster: WBPaper00029359_1217
      WBPaper00029359_1280
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1548
      WBPaper00029359_1604
      WBPaper00031132:LiCl_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00040209:B.thuringiensis_upregulated_MY15
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00048988:daf-16(mu86)_upregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_specific
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056826:SGP_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059440:LAG-1_interacting_germline
      WBPaper00059471:EGL-43_interacting
      WBPaper00059987:Wounding_upregulated
      WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00061340:GLR
      WBPaper00061340:hmc_and_homolog
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061527:C10C5.2-Y58A7A.3
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00025032:cluster_20
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028482:PA14_upregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00035560:ahr-1_downregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_D
      WBPaper00036286:Pattern_F
      WBPaper00037695:WC_5-day
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00042234:xpa-1_upregulated
      WBPaper00042548:miRISC_enriched
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053827:pyoverdine_upregulated
      [cgc5767]:cluster_6
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(41_min)
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
    Interaction: WBInteraction000556188
      WBInteraction000556189
      WBInteraction000556190
      WBInteraction000556191
  Map_info: Map: III Position: -26.3293 Error: 0.015704
    Positive: Positive_clone: C09F5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00028994
    WBPaper00030263
    WBPaper00038491
    WBPaper00047380
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene