WormBase Tree Display for Gene: WBGene00015418

WBGene00015418 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 3
    Name: CGC_name: pac-1 Person_evidence: WBPerson6440
            WBPerson440
      Sequence_name: C04D8.1
      Molecular_name (18)
      Other_name: CEGAP Accession_evidence: EMBL U02289
        CELE_C04D8.1 Accession_evidence: NDB BX284603
      Public_name: pac-1
    DB_info: Database: AceView gene 3J607
        WormQTL gene WBGene00015418
        WormFlux gene WBGene00015418
        NDB locus_tag CELE_C04D8.1
        Panther gene CAEEL|WormBase=WBGene00015418|UniProtKB=P34288
          family PTHR23176
        NCBI gene 176201
        RefSeq protein NM_001136361.5
            NM_001306726.3
            NM_001306727.4
            NM_001306725.3
            NM_066476.7
            NM_001306728.4
        SwissProt UniProtAcc P34288
        TrEMBL UniProtAcc U4PM34
            U4PRC7
            U4PBN0
            U4PBA1
        UniProt_GCRP UniProtAcc P34288
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:56 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 07 Feb 2008 17:23:14 WBPerson2970 Name_change: CGC_name: pac-1
        3 03 Nov 2008 13:41:14 WBPerson1849 Event: Acquires_merge: WBGene00018372
      Acquires_merge: WBGene00018372
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pac
    Allele (340)
    Strain: WBStrain00032310
      WBStrain00007530
      WBStrain00007531
    RNASeq_FPKM (74)
    GO_annotation (18)
    Contained_in_operon: CEOP3814
    Ortholog (40)
    Paralog: WBGene00008006 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: pac-1 encodes a RhoGAP (Rho guanosine triphosphatase (GTPase) activating protein); in the embryo, PAC-1 is essential for establishment of radial (inner-outer) asymmetry and specifically, for differential localization of PAR-6, PAR-3, and PKC-3 to outer somatic cell surfaces devoid of cell-cell contacts; in regulating PAR protein localization, PAC-1 appears to act by spatially regulating activity of the CDC-42 Rho GTPase which can bind PAR-6 and is required, genetically, for PAR-6 localization to the outer cell surface; a PAC-1::GFP fusion protein expressed in the early embryo and in cultured embryos localizes to points of cell-cell contact. Paper_evidence: WBPaper00031968
          Curator_confirmed: WBPerson1843
          Date_last_updated: 30 Jun 2008 00:00:00
      Automated_description: Enables GTPase activator activity. Involved in Rho protein signal transduction; protein localization; and regulation of gastrulation. Located in cell junction. Expressed in anus; epithelial cell; hypodermis; pharynx; and pm7. Is an ortholog of human ARHGAP23 (Rho GTPase activating protein 23). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C04D8.1a
      C04D8.1b
      C04D8.1d
      C04D8.1e
      C04D8.1f
      C04D8.1g
    Corresponding_CDS_history: C04D8.1:wp92
      C04D8.1a:wp196
      C04D8.1c:wp275
    Corresponding_transcript: C04D8.1a.1
      C04D8.1b.1
      C04D8.1d.1
      C04D8.1e.1
      C04D8.1f.1
      C04D8.1g.1
    Other_sequence (24)
    Associated_feature (62)
  Experimental_info: RNAi_result (7)
    Expr_pattern: Expr68
      Expr2035
      Expr8161
      Expr12368
      Expr13517
      Expr1016440
      Expr1036597
      Expr1143693
      Expr2014677
      Expr2032910
    Drives_construct: WBCnstr00020487
      WBCnstr00020494
      WBCnstr00028863
    Construct_product (16)
    Microarray_results (39)
    Expression_cluster: WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00041506:P2_enriched
      WBPaper00042561:smg-2(RNAi)_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049626:UNC-75_target
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055648:germline_expressed
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058969:RIS_enriched
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059754:C.neoformans_H99_upregulated
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061340:ADEsh
      WBPaper00061340:AIM
      WBPaper00061340:CEPsh
      WBPaper00061340:CEPso
      WBPaper00061340:FLP
      WBPaper00061340:g2
      WBPaper00061340:Glia
      WBPaper00061340:IL1_parent
      WBPaper00061340:ILsh_OLLsh_OLQsh
      WBPaper00061340:M1_parent
      WBPaper00061340:OLL_parent
      WBPaper00061340:OLQ_parent
      WBPaper00061340:XXX
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061527:srj-42-srw-113
      WBPaper00061527:trcs-2_5724-R11A8.7_17645
      WBPaper00061651:BAG_enriched
      WBPaper00061651:HSN_enriched
      WBPaper00061651:M1_enriched
      WBPaper00061651:RMF_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064716:paraquat_upregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065841:59_0
      WBPaper00065841:105_0
      cgc4386_cluster_5_5
      WBPaper00005475:Aging-regulated
      WBPaper00025032:cluster_142
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026980:intestine_enriched
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00034661:AgNPs_downregulated
      WBPaper00034739:N2moreDR1350
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.5
      WBPaper00040823:alg-1(gk214)_downregulated
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042234:xpa-1_upregulated
      WBPaper00042548:miRISC_enriched
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (75)
  Map_info: Map: III Position: -0.25513 Error: 0.000591
    Positive: Positive_clone: C04D8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene