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WormBase Tree Display for Gene: WBGene00012641

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Name Class

WBGene00012641SMapS_parentSequenceY39A1A
IdentityVersion2
NameCGC_nameepg-6Paper_evidenceWBPaper00039980
Person_evidenceWBPerson716
Sequence_nameY39A1A.1
Molecular_name (12)
Other_nameCELE_Y39A1A.1Accession_evidenceNDBBX284603
Public_nameepg-6
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:54WBPerson1971EventImportedInitial conversion from CDS class of WS125
212 Aug 2011 13:38:18WBPerson2970Name_changeCGC_nameepg-6
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classepg
Allele (63)
StrainWBStrain00002335
WBStrain00008602
RNASeq_FPKM (74)
GO_annotation (21)
Contained_in_operonCEOP3684
Ortholog (40)
ParalogWBGene00018294Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionepg-6 encodes a WD40 repeat-containing protein that is related to the mammalian WIPI3/4 family of proteins (WD40 repeat protein interacting with phosphoinositides); in C. elegans, epg-6 activity is required for autophagic processes, specifically for the formation of autophagosomes from omegasomes (PtdIns(3)P-enriched endoplasmic reticulum subdomains) and for proper distribution of the autophagic proteins ATG-9 and EPG-1; EPG-6 binds ATG-2 in vitro and in vivo and also binds, in vitro, PtdIns(3)P and PtdIns(5)P and weakly binds PtdIns(4)P and PtdIns(3,5)P2; an EGP-6::GFP reporter fusion protein is widely expressed during embryonic and post-embryonic development, and localizes diffusely to the cytoplasm.Paper_evidenceWBPaper00039980
Curator_confirmedWBPerson1843
Date_last_updated03 Aug 2011 00:00:00
Automated_descriptionEnables phosphatidylinositol phosphate binding activity. Involved in autophagosome assembly. Located in cytoplasm. Expressed widely. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Is an ortholog of human WDR45 (WD repeat domain 45).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0110739Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:28912)
Molecular_infoCorresponding_CDSY39A1A.1a
Y39A1A.1b
Y39A1A.1c
Y39A1A.1d
Corresponding_CDS_historyY39A1A.1:wp61
Y39A1A.1:wp93
Corresponding_transcriptY39A1A.1a.1
Y39A1A.1b.1
Y39A1A.1c.1
Y39A1A.1d.1
Other_sequence (21)
Associated_featureWBsf651465
WBsf651466
WBsf994086
WBsf994087
WBsf227477
WBsf227478
Experimental_infoRNAi_result (9)
Expr_patternChronogram1690
Expr6939
Expr9612
Expr1020256
Expr1035583
Expr1159613
Expr2011345
Expr2029581
Drives_constructWBCnstr00003004
WBCnstr00014173
Construct_productWBCnstr00014173
Microarray_results (29)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00037946:MAB-5_interacting
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00038168:lin-15B(n744)_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045257:bar-1(ga80)_upregulated
WBPaper00045521:Gender_Neutral
WBPaper00045774:clk-1_upregulated
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046509:htz-1(ok3099)_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049626:UNC-75_target
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050514:CEBP-1_interacting
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050743:elli-1(sam-3)_downregulated
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051039:germline_enriched
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053388:dauer_regulated_Cluster2
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055648:germline_expressed
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056161:male_enriched_siRNA
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058598:sin-3(tm1276)_upregulated
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00059664:srbc-48(ac23)_downregulated
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00061007:S.aquatilis_downregulated
WBPaper00061203:sin-3(tm1276)_downregulated
WBPaper00061203:spr-1(ok2144)_downregulated
WBPaper00061479:HDA-1_interacting_protein
WBPaper00061527:F31C3.4_6048-cutc-1_15804
WBPaper00061530:nhr-49(e2144)_upregulated
WBPaper00062056:lin-35(n745)_upregulated
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
WBPaper00064716:paraquat_upregulated
WBPaper00064769:him-17(me24)_downregulated
WBPaper00065096:25C_vs_20C_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066110:tetraploid_vs_diploid_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4489_group_12
WBPaper00005124:estrogen_10-5M_regulated
WBPaper00025032:cluster_192
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00034661:AgNPs_downregulated
WBPaper00035905:FBF-1_Associated
WBPaper00036286:Pattern_B
WBPaper00038231:Cry5B_1.5-fold_upregulated
WBPaper00041002:HF_3d_2.0mM_Down
WBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00048989:N2_rapamycin_downregulated
WBPaper00050538:Fasting_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:cluster_7
[cgc5767]:expression_class_E
[cgc5767]:expression_class_ET
[cgc5767]:expression_class_ET_max(101_min)
[cgc5767]:expression_class_E_pi(23_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc5767]:expression_class_MET
[cgc6390]:Cluster_E
[cgc6390]:mixed_oogenesis-somatic
Interaction (20)
Map_infoMapIIIPosition3.81526Error0.046215
PositivePositive_cloneY39A1AInferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (12)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene