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WormBase Tree Display for Gene: WBGene00012553

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Name Class

WBGene00012553SMapS_parentSequenceY37D8A
IdentityVersion3
NameCGC_namecox-5APerson_evidenceWBPerson117
WBPerson7169
Sequence_nameY37D8A.14
Molecular_nameY37D8A.14
Y37D8A.14.1
CE20218
Other_namecco-2Person_evidenceWBPerson1157
CELE_Y37D8A.14Accession_evidenceNDBBX284603
Public_namecox-5A
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:53WBPerson1971EventImportedInitial conversion from CDS class of WS125
231 Aug 2005 14:07:05WBPerson2970Name_changeCGC_namecco-2
305 Sep 2017 13:25:30WBPerson2970Name_changeCGC_namecox-5A
Other_namecco-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcox
Allele (24)
RNASeq_FPKM (74)
GO_annotation (12)
Ortholog (38)
Structured_descriptionConcise_descriptioncco-2 encodes the C. elegans ortholog of the cytochrome c oxidase (COX) subunit Va (COX Va); loss of cco-2 activity via RNAi results in a shortened life span, reduced fertility, and defects in mitochondrial respiratory chain function.Paper_evidenceWBPaper00032427
Curator_confirmedWBPerson1843
Date_last_updated08 Nov 2010 00:00:00
Automated_descriptionPredicted to enable metal ion binding activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex IV. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Is an ortholog of human COX5A (cytochrome c oxidase subunit 5A).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0070505Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2267)
Molecular_infoCorresponding_CDSY37D8A.14
Corresponding_transcriptY37D8A.14.1
Other_sequence (143)
Associated_feature (15)
Experimental_infoRNAi_result (17)
Expr_patternExpr1017887
Expr1035556
Expr1159398
Expr2009765
Expr2028005
Microarray_results (26)
Expression_clusterWBPaper00032528:L3_enriched
WBPaper00035073:mitochondria_protein
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038213:E.coli(LF82)_72h_upregulated
WBPaper00038289:oocyte_protein
WBPaper00040221:DAF-12_target_ALF4
WBPaper00040529:TWE_regulated
WBPaper00040965:lipid-droplet_associated_protein
WBPaper00042477:rsr-2(RNAi)_upregulated_RNAseq
WBPaper00044128:daf-2(e1370)_downregulated
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:flat_dev_expression
WBPaper00044746:aging_downregulated_Day5
WBPaper00044746:aging_downregulated_HeatShock
WBPaper00045521:Gender_Neutral
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00048910:mRNA-interacting_protein
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050698:DEP-1_interacting
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053289:DREAM-target
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
WBPaper00053388:dauer_regulated_Cluster6
WBPaper00053599:female_vs_male_downregulated
WBPaper00053615:SMO-1_target
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00054913:AKIR-1_interacting_protein
WBPaper00055049:S.gordonii_downregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055648:germline_expressed
WBPaper00056284:ints-5(RNAi)_downregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056501:P.aeruginosa_upregulated_mitochondria-protein
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00056900:PID-3_interacting
WBPaper00059194:KLF-1_interacting
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00059763:neuron_expressed
WBPaper00059895:wounding_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061221:H4K8ac_interacting
WBPaper00061341:28C_48h_downregulated
WBPaper00061377:MYRF-1_interacting
WBPaper00061377:MYRF-2_interacting
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061527:F45H10.2-R53.4_21676
WBPaper00061651:Distal_tip_cell_enriched
WBPaper00061651:Gonadal_sheath_cell_enriched
WBPaper00061651:HSN_enriched
WBPaper00061651:Spermatheca_enriched
WBPaper00062193:hsf-1(RNAi)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062498:PPM-1.D_interacting
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
WBPaper00064055:trl-1(cas1077)_downregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064201:SNA-3_interacting
WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
WBPaper00064716:paraquat_downregulated
WBPaper00064750:0.1mg-nanoplastics_upregulated_protein
WBPaper00064750:10mg-nanoplastics_upregulated_protein
WBPaper00065120:body-muscle-transcriptome
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_Ref
cgc4386_cluster_1_5
cgc4489_group_3
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00034661:AgNPs_upregulated
WBPaper00036286:Pattern_G
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00044091:Bpseudomallei_repressed_12h
WBPaper00045401:N.parisii_34h_upregulated_N2
WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
Interaction (95)
Map_infoMapIIIPosition19.5686Error0.139069
PositivePositive_cloneY37D8AInferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (7)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene