WormBase Tree Display for Gene: WBGene00012140

WBGene00012140 SMap: S_parent: Sequence: T28F4
  Identity: Version: 1
    Name: Sequence_name: T28F4.5
      Molecular_name: T28F4.5
        T28F4.5.1
        CE06527
        T28F4.5.2
      Other_name: CELE_T28F4.5 Accession_evidence: NDB BX284601
      Public_name: T28F4.5
    DB_info: Database: AceView gene 1I69
        WormQTL gene WBGene00012140
        WormFlux gene WBGene00012140
        NDB locus_tag CELE_T28F4.5
        Panther gene CAEEL|WormBase=WBGene00012140|UniProtKB=Q22850
          family PTHR13177
        NCBI gene 172503
        RefSeq protein NM_059701.8
        TREEFAM TREEFAM_ID TF318830
        TrEMBL UniProtAcc Q22850
        UniProt_GCRP UniProtAcc Q22850
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:53 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
    Status: Live
  Gene_info: Biotype: SO:0001217
    Allele (21)
    RNASeq_FPKM (74)
    GO_annotation: 00076609
      00076610
      00076611
      00076612
    Ortholog (24)
    Paralog: WBGene00010019 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: The T28F4.5 gene encodes a homolog of Death Associated Protein 1 (DAP-1) protein that may be involved in apoptosis. Paper_evidence: WBPaper00004589
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable death domain binding activity. Predicted to be involved in apoptotic signaling pathway; cellular response to amino acid starvation; and negative regulation of autophagy. Is an ortholog of human DAP (death associated protein). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info (4)
  Experimental_info: RNAi_result: WBRNAi00054444 Inferred_automatically: RNAi_primary
      WBRNAi00036105 Inferred_automatically: RNAi_primary
      WBRNAi00004348 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1025397
      Expr1035369
      Expr1157988
      Expr2006634
      Expr2024851
    Drives_construct: WBCnstr00030111
    Construct_product: WBCnstr00030111
    Microarray_results (25)
    Expression_cluster: WBPaper00032528:L3_enriched
      WBPaper00033065:isp-1-1(qm150)_upregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00034761:hlh-30_downregulated
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
      WBPaper00040135:orn-1(RNAi)_downregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044128:daf-2(e1370)_upregulated
      WBPaper00044128:DietaryRestriction_upregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044736:rising_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046303:P.aeruginosa_downregulated_protein
      WBPaper00046337:monosomal_N2_vs_daf-2_downregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_upregulated_protein
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00046795:starvation_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048926:miaserin_upregulated_adult-day10
      WBPaper00048952:glucose_repressed
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049018:ham-3(RNAi)_downregulated
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050053:muscle_enriched_Day12
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050496:RID_enriched
      WBPaper00050496:unc-39(hp701)_regulated
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-5(ram2)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053771:up_at_3h-NaCl
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055969:electromagnetic-field_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056218:daf-16(mu86)_upregulated_Day5
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:SGP_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059373:stt-3(RNAi)_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:CEPsh
      WBPaper00061340:CEPso
      WBPaper00061340:F_U
      WBPaper00061340:Glia
      WBPaper00061340:ILsh_OLLsh_OLQsh
      WBPaper00061340:K_Kprime
      WBPaper00061340:M_cell
      WBPaper00061340:Parent_of_AMsh_URB
      WBPaper00061340:Parent_of_g1P_I3
      WBPaper00061340:rect_D
      WBPaper00061340:Z1_Z4
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061409:neuronal-fzo-1(RNAi)_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:F54D5.3_7003-F54D5.3_7004
      WBPaper00061651:AVG_enriched
      WBPaper00061651:AVH_enriched
      WBPaper00061651:AVJ_enriched
      WBPaper00061651:CAN_enriched
      WBPaper00061651:Coelomocyte_enriched
      WBPaper00061651:M5_enriched
      WBPaper00061651:PVP_enriched
      WBPaper00061651:PVR_enriched
      WBPaper00061651:PVW_enriched
      WBPaper00061651:RIC_enriched
      WBPaper00061651:RID_enriched
      WBPaper00061651:SMD_enriched
      WBPaper00061651:VB_enriched
      WBPaper00061651:XXX_enriched
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061753:csr-1(tor159)_downregulated_20C
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062456:doxycycline_upregulated_N2_protein
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064225:heat-shock_upregulated_protein
      WBPaper00064502:spe-44(fx110)_downregulated
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064735:bet-1(RNAi)_vs_N2_upregulated
      WBPaper00064735:bet-1(uth41)_vs_N2_upregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00064952:Day1_vs_L4_upregulated_25C
      WBPaper00064952:Day5_vs_Day1_downregulated_25C
      WBPaper00064952:Day10_vs_Day1_downregulated_25C
      WBPaper00064992:heat-shock_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day1_20C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065199:Transgeneration-starvation_regulated_fed
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065392:Lb.plantarum_downregulated
      WBPaper00065392:Lb.reuteri_downregulated
      WBPaper00065392:P.pentosaceus_downregulated
      WBPaper00065623:55
      WBPaper00065746:tmc-1(rg1003)_downregulated
      WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00065995:M.humicola-extract_downregulated_N2
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4386_cluster_2_2
      cgc4489_group_12
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00029437:dcr-1_upregulated
      WBPaper00029437:rde-4_upregulated
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp2
      WBPaper00033101:spr-5_regulated
      WBPaper00034739:N2moreDR1350
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00036286:Pattern_D
      WBPaper00037113:CPF_16C_down-regulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
      WBPaper00040210:Chlorpyrifos_16C_regulated
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042128:gei-8(ok1671)_upregulated
      WBPaper00042178:hlh-29(tm284)_upregulated
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00044013:nasp-1_downregulated
      WBPaper00044091:Bpseudomallei_induced_2h
      WBPaper00045015:nhr-25(RNAi)_upregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00050515:nipi-3(fr4)_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5976]:class_1
    Interaction (143)
  Map_info: Positive: Positive_clone: T28F4 Inferred_automatically: From sequence, transcript, pseudogene data
    Interpolated_map_position: I 2.09689
  Reference: WBPaper00033099
  Method: Gene