WormBase Tree Display for Gene: WBGene00011674

WBGene00011674 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 2
    Name: CGC_name: cyp-13A8
      Sequence_name: T10B9.4
      Molecular_name: T10B9.4
        T10B9.4.1
        CE13541
      Other_name: CELE_T10B9.4 Accession_evidence: NDB BX284602
      Public_name: cyp-13A8
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-13A8
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (29)
    RNASeq_FPKM (74)
    GO_annotation: 00079953
      00079954
      00079955
      00118907
      00118908
      00118909
      00118910
    Ortholog (84)
    Paralog (12)
    Structured_description: Concise_description: cyp-13A8 encodes one of ~80 C. elegans cytochrome P450s: membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyze the oxidative metabolism of a variety of exogenous compounds and endogenous substrates; loss of cyp-13A8 activity in large-scale RNAi screens results in low levels of embryonic lethality, sluggish locomotion, and a clear appearance. Paper_evidence: WBPaper00005654
          Curator_confirmed: WBPerson1843
          Date_last_updated: 20 Nov 2008 00:00:00
      Automated_description: Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Expressed in hypodermis and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Ghosal hematodiaphyseal syndrome; familial Mediterranean fever; and leukemia (multiple). Is an ortholog of several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4); CYP3A5 (cytochrome P450 family 3 subfamily A member 5); and CYP3A7 (cytochrome P450 family 3 subfamily A member 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (8)
  Molecular_info: Corresponding_CDS: T10B9.4
    Corresponding_transcript: T10B9.4.1
    Other_sequence: MI04235
      MI01651
      ES743048.1
      PPC00382_1
      MIC02148_1
    Associated_feature: WBsf650463
      WBsf989152
      WBsf1012907
      WBsf1012908
      WBsf1012909
  Experimental_info: RNAi_result: WBRNAi00035423 Inferred_automatically: RNAi_primary
      WBRNAi00053018 Inferred_automatically: RNAi_primary
      WBRNAi00094897 Inferred_automatically: RNAi_primary
      WBRNAi00092626 Inferred_automatically: RNAi_primary
      WBRNAi00009149 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr15175
      Expr1027602
      Expr1156618
      Expr2010688
      Expr2028927
    Drives_construct: WBCnstr00030479
      WBCnstr00042031
    Construct_product: WBCnstr00030479
    Microarray_results (16)
    Expression_cluster: WBPaper00006195:azacoprostane_downregulated
      WBPaper00027022:tax-6(jh107)_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044316:HgCl2_20uM_upregulated
      WBPaper00044427:lbp-5(tm1618)_upregulated
      WBPaper00045017:blmp-1(tm548)_upregulated
      WBPaper00045257:bar-1(ga80)_upregulated
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045774:clk-1_upregulated
      WBPaper00046415:lithium_downregulated
      WBPaper00049498:npr-1(ur89)_regulated_4
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_lin-65(n3441)
      WBPaper00050412:cco-1(RNAi)_upregulated_met-2(ok2307)
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050504:hrp-2(RNAi)_upregulated
      WBPaper00050990:NMDA-neuron_enriched
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00052856:Cadmium_regulated
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053810:sod-2(ok1030)_upregulated
      WBPaper00054410:set-26(tm2467)_upregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:hif-1(ia4)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_L3
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056586:mpk-2(ok219)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059194:KLF-1_interacting
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
      WBPaper00060084:cco-1(RNAi)_upregulated_N2
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
      WBPaper00060445:nfki-1(cer1)_downregulated_L1
      WBPaper00060445:nfki-1(cer1)_downregulated_L4
      WBPaper00060764:swsn-1(os22ts)_upregulated
      WBPaper00060909:atfs-1(et18)_upregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061527:cyp-14A4-cyp-13A4
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061653:alh-4(hj221)_upregulated
      WBPaper00062237:dnj-21(RNAi)_upregulated_protein
      WBPaper00062305:P.brevicompactum_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_30min_upregulated_zip-1(jy13)
      WBPaper00062347:blmp-1(tm548)_upregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00062606:rotenone_upregulated
      WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
      WBPaper00064291:antimycin_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065746:eat-2(ad1113)_upregulated
      WBPaper00065746:tmc-1(rg1003)_downregulated
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065995:M.humicola-extract_upregulated_old-1(ok1273)
      WBPaper00066118:cyclobutrifluram_upregulated
      WBPaper00066163:crtc-1(wbm18)_downregulated_set-2(ok952)
      WBPaper00066163:set-2(ok952)_upregulated_N2
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4489_group_9
      WBPaper00006465:II_ethanol_late_induction
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00041207:CE_dauer_up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00042067:Cu2+_upregulated_WT
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
    Interaction (34)
  Map_info: Map: II Position: 1.72429 Error: 0.00034
    Positive: Positive_clone: T10B9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00042257
    WBPaper00055090
    WBPaper00064073
    WBPaper00064598
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene