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WormBase Tree Display for Gene: WBGene00011672

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Name Class

WBGene00011672SMapS_parentSequenceT10B9
IdentityVersion2
NameCGC_namecyp-13A5
Sequence_nameT10B9.2
Molecular_name (3)
Other_nameCELE_T10B9.2Accession_evidenceNDBBX284602
Public_namecyp-13A5
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:52WBPerson1971EventImportedInitial conversion from CDS class of WS125
221 Sep 2004 09:38:16WBPerson1971Name_changeCGC_namecyp-13A5
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcyp
Allele (36)
RNASeq_FPKM (74)
GO_annotation00079947
00079948
00079949
00118899
00118900
00118901
00118902
Ortholog (64)
Paralog (12)
Structured_descriptionConcise_descriptioncyp-13A5 encodes one of ~80 C. elegans cytochrome P450s: membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyze the oxidative metabolism of a variety of exogenous compounds and endogenous substrates; loss of cyp-13A5 activity in large-scale RNAi screens results in uncoordinated locomotion, decreased and/or slow growth, and cadmium hypersensitivity.Paper_evidenceWBPaper00005654
WBPaper00006395
WBPaper00030811
Curator_confirmedWBPerson1843
Date_last_updated20 Nov 2008 00:00:00
Automated_descriptionPredicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Human ortholog(s) of this gene implicated in several diseases, including Ghosal hematodiaphyseal syndrome; familial Mediterranean fever; and leukemia (multiple). Is an ortholog of several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4); CYP3A5 (cytochrome P450 family 3 subfamily A member 5); and CYP3A7 (cytochrome P450 family 3 subfamily A member 7).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:8552Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2638)
DOID:3526Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11609)
DOID:2987Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2637)
DOID:9952Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2638)
DOID:0112251Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11609)
DOID:0080630Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2638)
DOID:10825Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2638)
DOID:1612Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2637)
Molecular_infoCorresponding_CDST10B9.2
Corresponding_transcriptT10B9.2.1
Other_sequenceJI174138.1
Oden_isotig14710
Acan_isotig21796
Associated_featureWBsf223709
WBsf223710
Experimental_infoRNAi_resultWBRNAi00018525Inferred_automaticallyRNAi_primary
WBRNAi00070152Inferred_automaticallyRNAi_primary
WBRNAi00053015Inferred_automaticallyRNAi_primary
WBRNAi00035421Inferred_automaticallyRNAi_primary
WBRNAi00092623Inferred_automaticallyRNAi_primary
Expr_patternExpr1156616
Expr2010685
Expr2028924
Drives_constructWBCnstr00030481
Construct_productWBCnstr00030481
Microarray_results (14)
Expression_clusterWBPaper00032022:X-Ray_upregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038168:lin-15B(n744)_upregulated
WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00040560:hpl-2_L3_upregulated
WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
WBPaper00042194:Tryptophan_upregulated
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
WBPaper00042561:smg-2(RNAi)_upregulated
WBPaper00042561:smgl-1(RNAi)_downregulated
WBPaper00043945:MeHg_upregulated
WBPaper00044030:nhr-8(hd117)_upregulated
WBPaper00044037:eat-2_upregulated
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044434:2-deoxy-D-glucose_downregulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044743:wdr-23_neuron_upregulated
WBPaper00045017:blmp-1(tm548)_upregulated
WBPaper00045257:bar-1(ga80)_upregulated
WBPaper00045316:prg-1_upregulated_L3
WBPaper00045390:tunicamycin_downregulated
WBPaper00045390:ubc-9(RNAi)_downregulated
WBPaper00045934:wrn-1(gk99)_downregulated
WBPaper00045971:tunicamycin_upregulated_control
WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
WBPaper00046415:lithium_downregulated
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
WBPaper00046805:csr-1(RNAi)_upregulated_Set1
WBPaper00047131:daf-2(e1370)_downregulated_hel-1(gk148684)-background
WBPaper00048926:miaserin_upregulated_adult-day5
WBPaper00049018:ham-3(RNAi)_upregulated
WBPaper00049018:swsn-2.2(RNAi)_upregulated
WBPaper00049217:TCER-1_downregulated
WBPaper00049334:CE_intestine_enriched
WBPaper00049368:daf-2(e1370)_upregulated
WBPaper00049495:starvation-refeeding_regulated
WBPaper00049498:npr-1(ur89)_regulated_7
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049635:dop-1(vs100)_upregulated
WBPaper00049920:hyl-2(tm2031)_upregulated
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00049954:BPA_upregulated
WBPaper00049954:BPS_upregulated
WBPaper00050096:P.aeruginosa_upregulated
WBPaper00050121:mir-60(n4947)_upregulated
WBPaper00050193:cec-4(ok3124)_upregulated_L1
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050332:daf-16(RNAi)_downregulated
WBPaper00050344:ASER-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050412:cco-1(RNAi)_upregulated_N2
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050504:hrp-2(RNAi)_upregulated
WBPaper00050561:indole_0.1mM-indole_upregulated
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
WBPaper00050990:intestine_enriched
WBPaper00050990:intestine_expressed
WBPaper00051021:4-bromodiphenyl-ether_upregulated
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051265:F4_hrde-1(tm1200)_downregulated
WBPaper00051404:alg-1(gk214)_downregulated
WBPaper00051404:alg-5(ram2)_downregulated
WBPaper00051437:Cit-SPIONs_downregulated
WBPaper00051540:exc-7(csb29);mbl-1(csb30)_upregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053402:cco-1(RNAi)_upregulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
WBPaper00053664:ins-11(tm1053)_upregulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
WBPaper00053771:up_at_3h-NaCl
WBPaper00053771:up_at_24h-NaCl
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00054493:hpl-2(tm1489)_downregulated
WBPaper00054872:egl-9(sa307)_downregulated
WBPaper00055013:hmg-3(bar24)_upregulated
WBPaper00055013:hmg-4(RNAi)_upregulated
WBPaper00055013:spt-16(RNAi)_upregulated
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055137:S.maltophilia_downregulated
WBPaper00055354:Psora_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin_upregulated
WBPaper00055386:eat-2(ad465)_downregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
WBPaper00055941:nuo-6(qm200)_upregulated
WBPaper00055971:nhl-2(ok818)_20C_upregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056167:Cry5B_downregulated
WBPaper00056167:ifo-1(kc2)_downregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056218:daf-16(mu86)_upregulated_Day7
WBPaper00056290:mdt-15(mg584)_upregulated
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:flcn-1(ok975)_upregulated
WBPaper00056550:ceh-60(ok1485)_downregulated_AdultDay4
WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
WBPaper00056586:kri-1(ok1251)_upregulated
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057041:unc-70(cas983)_downregulated
WBPaper00057068:Cadmium_upregulated
WBPaper00057068:ints-4(RNAi)_upregulated
WBPaper00057196:raga-1(ok386)_upregulated)
WBPaper00058711:paraquat_downregulated
WBPaper00058711:wdr-5(ok1417)_downregulated
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00058948:npr-8(ok1439)_downregulated_OP50
WBPaper00058948:npr-8(ok1439)_upregulated_PA14
WBPaper00058948:PA14_downregulated
WBPaper00058958:10mGy-irradiation-72h_upregulated
WBPaper00059117:B.subtilis_upregulated
WBPaper00059253:stearic-acid_upregulated
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
WBPaper00059537:ngn-1(ok2200)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059735:glucose_downregulated_lpin-1(RNAi)
WBPaper00059739:hira-1(gk835598)_upregulated_adult
WBPaper00059754:E.faecalis_OG1RF_upregulated
WBPaper00059754:P.aeruginosa_PA14_upregulated
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059839:S.maltophilia_regulated
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060084:cco-1(RNAi)_upregulated_N2
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060273:vrk-1(RNAi)_downregulated
WBPaper00060278:atp-2(RNAi)_upregulated
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
WBPaper00060445:nfki-1(cer1)_downregulated_L1
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060683:hlh-11(overexpression)_upregulated
WBPaper00060764:swsn-1(os22ts)_upregulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
WBPaper00060921:tph-1(mg280)_upregulated
WBPaper00061040:eat-2(ad1116)_downregulated
WBPaper00061081:skpo-1(ok1640)_upregulated_OP50
WBPaper00061340:FLP
WBPaper00061340:pm6
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061422:let-607(RNAi)_regulated
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061424:Diet_MYb131_upregulated
WBPaper00061527:W01F3.2_1554-Y106G6D.8
WBPaper00061530:nhr-49(e2144)_upregulated
WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_upregulated
WBPaper00061753:csr-1(tor159)_downregulated_20C
WBPaper00061823:mex-3(spr9)_downregulated
WBPaper00061952:daf-18(nr2037)_upregulated
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062118:neural-HSF-1_upregulated
WBPaper00062146:MOG-7-degron_2h_regulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062167:mbl-1(tm1563)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062237:dnj-21(RNAi)_upregulated_protein
WBPaper00062305:P.brevicompactum_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062345:bortezomib_4h_upregulated_N2
WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
WBPaper00062345:bortezomib_30min_upregulated_N2
WBPaper00062345:bortezomib_30min_upregulated_zip-1(jy13)
WBPaper00062347:blmp-1(tm548)_upregulated
WBPaper00062354:H.zoospora_12h_regulated
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062440:crh-1(syb385)_downregulated
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062446:nhr-8(ok186)_upregulated
WBPaper00062497:xpf-1(tm2842)_upregulated
WBPaper00062587:lsl-1(ljm1)_upregulated
WBPaper00062587:lsl-1(tm4769)_upregulated
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064005:starvation_upregulated_N2_protein
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064107:lin-35(n745)_upregulated
WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
WBPaper00064130:Beta-Amyloid_upregulated_protein
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064156:lipl-4(overexpress)_upregulated
WBPaper00064291:antimycin_upregulated
WBPaper00064509:static-magnetic-field_upregulated
WBPaper00064532:pals-22(jy3)_upregulated
WBPaper00064539:nhr-114(gk849)_upregulated
WBPaper00064632:daf-2(e1370)_downregulated_intestine
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064661:lpd-3(ok2138)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064727:daf-2(e1370)_downregulated
WBPaper00064762:freezing-thaw_regulated
WBPaper00064769:him-17(me24)_upregulated
WBPaper00064788:ketamine_upregulated
WBPaper00064789:Day12_vs_Day1_upregulated_neuron
WBPaper00064871:PA14_upregulated_AWA
WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
WBPaper00065029:cadmium_upregulated
WBPaper00065074:glna(-)_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065149:lin-52(n771)_upregulated
WBPaper00065392:P.pentosaceus_downregulated
WBPaper00065578:gcn-1(nc40)_upregulated
WBPaper00065734:unc-25(e156)_upregulated
WBPaper00065746:tmc-1(rg1003)_downregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
WBPaper00065841:9_0
WBPaper00065841:9_1
WBPaper00065841:9_2
WBPaper00065841:15_0
WBPaper00065841:24_0
WBPaper00065841:26_0
WBPaper00065841:26_1
WBPaper00065841:26_2
WBPaper00065841:27_0
WBPaper00065841:79_2
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066118:cyclobutrifluram_downregulated
WBPaper00066163:crtc-1(wbm18)_downregulated_set-2(ok952)
WBPaper00066163:set-2(ok952)_upregulated_N2
WBPaper00066232:ash-2(RNAi)_downregulated_WT
WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
cgc4489_group_12
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00028789:PA14_vs_OP50_upregulated_4hr
WBPaper00028789:PA14_vs_OP50_upregulated_8hr
WBPaper00029437:dcr-1_upregulated
WBPaper00030985:Enterococcus_faecalis_downregulated
WBPaper00030985:Erwinia_carotovora_downregulated
WBPaper00031003:hlh_1_enriched
WBPaper00031184:acrylamide_downregulated
WBPaper00032948:FedUp
WBPaper00034739:TreatmentAffectedGenes
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035873:osm-8_regulated
WBPaper00036123:Cadmium_regulated
WBPaper00036123:Fluoranthene_regulated
WBPaper00036130:mir-243_up_regulated
WBPaper00036286:Pattern_H
WBPaper00037113:Diazinon_16C_regulated
WBPaper00037695:WC_5-day
WBPaper00038172:crh-1null_up_regulated
WBPaper00038231:Cry5B_1.5-fold_upregulated
WBPaper00038231:Cry5B_2-fold_upregulated
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00040963:Q200_down
WBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00042178:hlh-29(tm284)_upregulated
WBPaper00042274:tbx-2(bx59)_upregulated
WBPaper00044013:nasp-1_downregulated
WBPaper00044535:male_upregulated
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00045294:50uM_TBBP_upregulated
WBPaper00045673:colistin_upregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00046083:oga-1(ok1207)_OP50_downregulated
WBPaper00047070:N2_UV_upregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00053827:pyoverdine_upregulated
WBPaper00055899:nitrotriazolone_regulated
WBPaper00056330:mrps-5(RNAi)_upregulated
[cgc6390]:herm_soma-enriched
Interaction (36)
Map_infoMapIIPosition1.7164Error0.000227
PositivePositive_cloneT10B9Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (7)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene