WormBase Tree Display for Gene: WBGene00010759

WBGene00010759 SMap: S_parent: Sequence: K10H10
  Identity: Version: 2
    Name: CGC_name: cysl-2 Paper_evidence: WBPaper00039977
          Person_evidence: WBPerson537
      Sequence_name: K10H10.2
      Molecular_name: K10H10.2
        K10H10.2.1
        CE16252
      Other_name: CELE_K10H10.2 Accession_evidence: NDB BX284602
      Public_name: cysl-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 29 Sep 2011 10:45:56 WBPerson2970 Name_change: CGC_name: cysl-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cysl
    Allele (39)
    Strain: WBStrain00033210
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (33)
    Paralog (12)
    Structured_description: Concise_description: cysl-2 encodes a homolog of sulfhydrylases/cysteine synthases. Paper_evidence: WBPaper00040881
          Curator_confirmed: WBPerson1843
          Date_last_updated: 13 Apr 2012 00:00:00
      Automated_description: Enables L-3-cyanoalanine synthase activity and cysteine synthase activity. Involved in cysteine biosynthetic process from serine. Predicted to be located in cytoplasm. Expressed in hypodermis and pharynx. Used to study Down syndrome. Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14250 Homo sapiens Paper_evidence: WBPaper00053600
          Curator_confirmed: WBPerson324
          Date_last_updated: 05 Mar 2018 00:00:00
  Models_disease_asserted: WBDOannot00000492
  Molecular_info: Corresponding_CDS: K10H10.2
    Corresponding_transcript: K10H10.2.1
    Other_sequence (85)
    Associated_feature: WBsf650753
      WBsf650754
      WBsf655398
      WBsf655399
      WBsf666380
      WBsf666381
      WBsf666382
      WBsf666383
      WBsf224281
  Experimental_info: RNAi_result: WBRNAi00050566 Inferred_automatically: RNAi_primary
      WBRNAi00098189 Inferred_automatically: RNAi_primary
      WBRNAi00016998 Inferred_automatically: RNAi_primary
      WBRNAi00060977 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr15038
      Expr1015759
      Expr1034709
      Expr1154275
      Expr2010749
      Expr2028985
    Drives_construct: WBCnstr00014465
      WBCnstr00031166
      WBCnstr00041880
    Construct_product: WBCnstr00031166
    Microarray_results (19)
    Expression_cluster: WBPaper00026640:Development_Group_VI
      WBPaper00028451:Low_abundance_spermatogenesis_enriched
      WBPaper00030894:daf-2(e1370ts)_upregulated
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032031:DConiospora_upregulated_cDNA_12h
      WBPaper00032425:up_in_lin-35
      WBPaper00032528:L3_enriched
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033065:isp-1-1(qm150)_upregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00035073:mitochondria_protein
      WBPaper00035926:A.hydrophila_regulated
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040285:H2S_1hr_upregulated
      WBPaper00040285:H2S_12hr_upregulated
      WBPaper00041075:hcf-1(-)_skn-1(+)_upregulated
      WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044037:eat-2_downregulated
      WBPaper00044260:1-methylnicotinamide_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045390:ubc-9(RNAi)_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046024:sleep_downregulated_oscillating
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046795:starvation_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047132:skn-1(RNAi)_downregulated
      WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent
      WBPaper00048926:miaserin_upregulated_adult-day5
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00049325:CB4856_vs_N2_DEG
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPA_downregulated
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050332:juglone_upregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050332:skr-1(RNAi)-skr-2(RNAi)_downregulated
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051069:isp-1(qm150)_upregulated
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051257:Levamisole_downregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00051555:atm-1(gk186)_regulated_protein
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053020:sta-1(ok587)_upregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053737:Anatase-TiO2-Nanoparticles_downregulated
      WBPaper00053771:down_by_skn-1(RNAi)_at_24h-NaCl
      WBPaper00053771:down_by_skn-1(RNAi)_at_dpy-7(e88)
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053792:Ochrobactrum_downregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00054872:egl-9(sa307)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00055941:hif-1(ia4)_downregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00055981:fog-2(q71)_downregulated
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056218:daf-16(mu86)_upregulated_Day3
      WBPaper00056218:daf-16(mu86)_upregulated_Day5
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056284:ints-5(RNAi)_upregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056501:P.aeruginosa_upregulated_mitochondria-protein
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
      WBPaper00057143:ztf-11(RNAi)_upregulated
      WBPaper00057196:raga-1(ok386)_downregulated)
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00058598:spn-4(tm291)_downregulated
      WBPaper00058665:amino-functionized-graphene-oxide_upregulated_mRNA
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058942:henn-1(pk2295)_downregulated
      WBPaper00059253:stearic-acid_upregulated
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059253:sucrose_upregulated
      WBPaper00059477:hlh-2(RNAi)_regulated
      WBPaper00059477:lin-32(RNAi)_regulated
      WBPaper00059566:P.aeruginosa_upregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_L4
      WBPaper00059754:P.aeruginosa_PA14_upregulated
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00060764:swsn-1(os22ts)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060909:atfs-1(et18)_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061007:X.citri_downregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:P_cell
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061390:daf-22(ok693)_ascarosides_downregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:mlt-9_22518-F33D4.6_14044
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061653:alh-4(hj221)_downregulated
      WBPaper00061753:csr-1(tor159)_upregulated_20C
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00061952:daf-18(yh1)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:daf-16(RNAi)_downregulated
      WBPaper00062193:hsf-1(RNAi)_upregulated
      WBPaper00062293:clk-1(qm30)_upregulated
      WBPaper00062293:isp-1(qm150)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062491:sma-3(wk30)_downregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064156:lbp-3(overexpress)_downregulated
      WBPaper00064232:amdh-1(uth29)_upregulated
      WBPaper00064581:amygdalin_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065288:mdt-15(tm2182)_downregulated
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065392:Lb.delbrueckii_upregulated
      WBPaper00065392:Lb.reuteri_upregulated
      WBPaper00065392:P.pentosaceus_upregulated
      WBPaper00065841:0_0
      WBPaper00065841:21_0
      WBPaper00065841:21_1
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      WBPaper00066085:sin-3(tm1276)_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4386_cluster_2_4
      cgc4489_group_8
      WBPaper00006465:IV_ethanol_late_repression
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025032:PAL-1_target_genes
      WBPaper00025099:NI_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_F
      WBPaper00026980:intestine_enriched
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:A_to_C_transit_increased
      WBPaper00032948:FedUp
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036286:Pattern_G
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00037113:DZN_16C_down-regulated
      WBPaper00038427:lin-54_germline_changed
      WBPaper00040210:Chlorpyrifos_16C_regulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00042128:gei-8(ok1671)_upregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045015:nhr-25(RNAi)_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045437:Toxic-Se_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00047021:MWCNT_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00051448:P.aeruginosa_Liquid-Killing_upregulated
      WBPaper00055435:AuNPs_upregulated
      WBPaper00055435:MUA-AuNP-0.5_upregulated
      WBPaper00055435:MUA-AuNP-3_upregulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:herm_soma-enriched
    Interaction (51)
    WBProcess: WBbiopr:00000008
  Map_info: Map: II Position: 23.0319 Error: 0.002146
    Positive: Positive_clone: K10H10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (22)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene