WormBase Tree Display for Gene: WBGene00009127

WBGene00009127 SMap: S_parent: Sequence: F25H5
  Identity: Version: 2
    Name: CGC_name: clsp-1 Person_evidence: WBPerson4143
      Sequence_name: F25H5.5
      Molecular_name: F25H5.5a
        F25H5.5a.1
        CE42710
        F25H5.5b
        CE46262
        F25H5.5b.1
      Other_name: CELE_F25H5.5 Accession_evidence: NDB BX284601
      Public_name: clsp-1
    DB_info: Database: AceView gene 1J736
        WormQTL gene WBGene00009127
        WormFlux gene WBGene00009127
        NDB locus_tag CELE_F25H5.5
        Panther gene CAEEL|WormBase=WBGene00009127|UniProtKB=O17838
          family PTHR14396
        NCBI gene 172742
        RefSeq protein NM_001377615.2
            NM_001264079.3
        TREEFAM TREEFAM_ID TF321962
        TrEMBL UniProtAcc G3MU54
            O17838
        UniProt_GCRP UniProtAcc O17838
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:49 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 07 Jun 2016 16:25:01 WBPerson2970 Name_change: CGC_name: clsp-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: clsp
    Allele (50)
    RNASeq_FPKM (74)
    GO_annotation: 00009076
      00009077
      00009078
      00009079
      00009080
      00009081
    Contained_in_operon: CEOP1540
    Ortholog (27)
    Structured_description: Concise_description: F25H5.5 encodes the C. elegans homologue of Claspin, an S-phase checkpoint component that interacts with Chk1 and negatively regulates cell cycle progression; in wild-type animals, loss of F25H5.5 activity results in some embryonic lethality; loss of F25H5.5 activity in a lin-35 mutant background, however, results in sterility, as well as smaller than normal body size, uncoordinated locomotion, and a protruding vulva; weaker F25H5.5 RNAi phenotypes are seen in lin-15B and eri-1; lin-15B backgrounds. Paper_evidence: WBPaper00004651
            WBPaper00029258
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 Feb 2008 00:00:00
      Automated_description: Predicted to enable anaphase-promoting complex binding activity. Predicted to be involved in mitotic DNA replication checkpoint signaling and mitotic G2 DNA damage checkpoint signaling. Located in nucleus. Is an ortholog of human CLSPN (claspin). Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F25H5.5a
      F25H5.5b
    Corresponding_CDS_history: F25H5.5:wp192
    Corresponding_transcript: F25H5.5a.1
      F25H5.5b.1
    Other_sequence (33)
    Associated_feature: WBsf649452
      WBsf220047
      WBsf220048
      WBsf220049
  Experimental_info: RNAi_result (19)
    Expr_pattern: Expr8725
      Expr1026132
      Expr1033977
      Expr1149465
      Expr2010255
      Expr2028497
    Drives_construct: WBCnstr00032443
    Construct_product: WBCnstr00007587
      WBCnstr00013483
      WBCnstr00032443
    Antibody: WBAntibody00002990
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032425:up_in_lin-35
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-35_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045521:Gender_Neutral
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056617:adr-1(tm668)_upregulated_embryo_protein
      WBPaper00056826:SGP_biased
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061340:M1_parent
      WBPaper00061340:mc3
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:kle-2_4298-vrk-1
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064505:tamoxifen_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065149:lin-52(n771)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_6_4
      cgc4489_group_2
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_B
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00040963:TA100_down
      WBPaper00040963:TA200_down
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045263:0.1mM-paraquat_upregulated
      [cgc5767]:cluster_30
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(41_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_E
      [cgc6390]:oogenesis-enriched
    Interaction (39)
  Map_info: Map: I Position: 3.63002
    Positive: Positive_clone: F25H5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00029258
    WBPaper00033469
    WBPaper00038491
    WBPaper00049963
    WBPaper00055090
    WBPaper00062444
    WBPaper00066002
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene