| WBGene00007918 | SMap | S_parent | Sequence | C34C6 |
|---|
| Identity | Version | 3 |
| | Name | CGC_name | sphk-1 | Person_evidence | WBPerson6511 |
| | | | | | WBPerson590 |
| | | Sequence_name | C34C6.5 |
| | | Molecular_name (12) |
| | | Other_name | tag-274 |
| | | | CELE_C34C6.5 | Accession_evidence | NDB | BX284602 |
| | | Public_name | sphk-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 22 Apr 2005 11:55:18 | WBPerson2970 | Name_change | CGC_name | tag-274 |
| | | | 3 | 03 Dec 2007 11:45:57 | WBPerson2970 | Name_change | CGC_name | sphk-1 |
| | | | | | | | Other_name | tag-274 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | sphk |
| | Allele (42) |
| | Strain | WBStrain00036171 |
| | | WBStrain00005455 |
| | RNASeq_FPKM (74) |
| | GO_annotation (47) |
| | Contained_in_operon | CEOP2384 |
| | Ortholog (43) |
| | Paralog | WBGene00020398 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00018674 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | sphk-1 encodes a sphingosine kinase orhtologous to the mammalian sphingosine kinases (SphK1 and SphK2); SPHK-1 activity is required, primarily in neurons, for promoting neurotransmitter release from synaptic vesicles at neuromuscular junctions; sphk-1 is expressedin the majority of cholinergic and GABAergic neurons, as well as in body wall muscle, intestine, and hypodermis; SPHK-1 localizes to discrete subsynaptic regions at presynaptic terminals; SPHK-1 abundance at presynaptic regions is regulated by a muscarinic signaling pathway that includes the muscarinc acetylcholine receptor GAR-3, the G protein subunit EGL-30, and the Trio Rho/GEF UNC-73. | Paper_evidence | WBPaper00041106 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 24 Oct 2013 00:00:00 |
| | | Automated_description | Predicted to enable D-erythro-sphingosine kinase activity and acetyltransferase activity. Involved in mitochondrial unfolded protein response; positive regulation of acetylcholine secretion, neurotransmission; and regulation of locomotion. Located in several cellular components, including mitochondrion; neuronal cell body; and presynaptic periactive zone. Expressed in several structures, including body wall musculature; excretory canal; intestine; linker cell; and neurons. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is an ortholog of human SPHK1 (sphingosine kinase 1) and SPHK2 (sphingosine kinase 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11240) |
| Molecular_info | Corresponding_CDS | C34C6.5a |
| | | C34C6.5b |
| | | C34C6.5c |
| | | C34C6.5d |
| | Corresponding_transcript (4) |
| | Other_sequence (17) |
| | Associated_feature | WBsf650356 |
| | | WBsf650357 |
| | | WBsf665256 |
| | | WBsf717740 |
| | | WBsf988798 |
| | | WBsf223536 |
| | | WBsf223537 |
| Experimental_info | RNAi_result (20) |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00015023 |
| | | WBCnstr00017093 |
| | | WBCnstr00017395 |
| | | WBCnstr00018187 |
| | | WBCnstr00037865 |
| | Construct_product (12) |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046509:lin-35(n745)_downregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055648:sperm_expressed |
| | | WBPaper00055827:pfd-6(gk493446)_upregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated |
| | | WBPaper00060006:nfyb-1(cu13)_upregulated_transcript |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:Y45F10D.7-C14C10.4 |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064992:Eugenol_downregulated |
| | | WBPaper00065086:JU1400_N.ferruginous_regulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065841:110_1 |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00029437:dcr-1_downregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_H |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:herm_soma-enriched |
| | Interaction (24) |
| Map_info | Map | II | Position | 0.842334 | Error | 0.001708 |
| | Positive | Positive_clone | C34C6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5162 |
| | | | 5443 |
| | Pseudo_map_position |
| Reference (23) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
