| WBGene00007413 | SMap | S_parent | Sequence | CHROMOSOME_II |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | pro-2 | Paper_evidence | WBPaper00028280 |
| | | | | Person_evidence | WBPerson275 |
| | | Sequence_name | C07E3.2 |
| | | Molecular_name | C07E3.2 |
| | | | C07E3.2.1 |
| | | | CE47947 |
| | | Other_name | CELE_C07E3.2 | Accession_evidence | NDB | BX284602 |
| | | Public_name | pro-2 |
| | DB_info | Database | AceView | gene | 2K630 |
| | | | WormQTL | gene | WBGene00007413 |
| | | | WormFlux | gene | WBGene00007413 |
| | | | NDB | locus_tag | CELE_C07E3.2 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00007413|UniProtKB=O17580 |
| | | | | family | PTHR12687 |
| | | | NCBI | gene | 174598 |
| | | | RefSeq | protein | NM_063823.6 |
| | | | SwissProt | UniProtAcc | O17580 |
| | | | TREEFAM | TREEFAM_ID | TF314829 |
| | | | UniProt_GCRP | UniProtAcc | O17580 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 03 Oct 2006 13:25:52 | WBPerson2970 | Name_change | CGC_name | pro-2 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | pro |
| | Allele (129) |
| | Strain | WBStrain00007711 |
| | RNASeq_FPKM (74) |
| | GO_annotation (12) |
| | Contained_in_operon | CEOP2692 |
| | Ortholog (32) |
| | Structured_description | Concise_description | pro-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Noc2p, which is required for intranuclear ribosome maturation and transport; in C. elegans, pro-2 activity is essential for larval growth, somatic gonad development, regulation of germline development and proliferation, and hence, fertility; by virtue of its similarity to Noc2p, PRO-2 is predicted to be a component of two heterodimeric intranuclear complexes that associate with, and aid in maturation of, different preribosomal particles. | Paper_evidence | WBPaper00028280 |
| | | | | | WBPaper00028281 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 01 Aug 2006 00:00:00 |
| | | Automated_description | Predicted to enable histone binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and ribosomal large subunit biogenesis. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Noc1p-Noc2p complex and Noc2p-Noc3p complex. Is an ortholog of human NOC2L (NOC2 like nucleolar associated transcriptional repressor). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info (4) |
| Experimental_info | RNAi_result (12) |
| | Expr_pattern | Expr1010517 |
| | | Expr1033192 |
| | | Expr1144078 |
| | | Expr2015104 |
| | | Expr2033342 |
| | Drives_construct | WBCnstr00033757 |
| | Construct_product | WBCnstr00033757 |
| | Microarray_results (15) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032031:DConiospora_upregulated_cDNA_24h |
| | | WBPaper00032097:CGH-1-associated-mRNA |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00042477:RSR-2_complex |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00050412:cco-1(RNAi)_downregulated_N2 |
| | | WBPaper00050686:glp-1(e2141)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:nucleus_specific |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055969:electromagnetic-field_downregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056034:pals-25(jy9)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_protein |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061340:M_cell |
| | | WBPaper00061340:Neuroblast_I6_M5 |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061527:ZK792.5-T26G10.1 |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062590:Aging_upregulated_hypodermis |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065158:25C_vs_15C_downregulated_AFD |
| | | WBPaper00065945:global-rpoa-2(-)_upregulated_transcript |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025032:cluster_180 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_H |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00053236:daf-16(mgDF50)_regulated_Starved |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:intrinsic |
| | Interaction (263) |
| Map_info | Map | II | Position | 2.42251 | Error | 0.00635 |
| | Positive | Positive_clone | C07E3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5697 |
| | | | 5698 |
| | | | 5699 |
| | | Pos_neg_data | 10762 |
| Reference | WBPaper00028280 |
| | WBPaper00033795 |
| | WBPaper00038491 |
| | WBPaper00039470 |
| | WBPaper00039496 |
| | WBPaper00044530 |
| | WBPaper00055090 |
| | WBPaper00065308 |
| Method | Gene |
