| WBGene00007054 | SMap | S_parent | Sequence | B0379 |
|---|
| Identity | Version | 3 |
| | Name | CGC_name | scpl-1 | Person_evidence | WBPerson56 |
| | | Sequence_name | B0379.4 |
| | | Molecular_name (9) |
| | | Other_name | tag-188 | Person_evidence | WBPerson201 |
| | | | CELE_B0379.4 | Accession_evidence | NDB | BX284601 |
| | | Public_name | scpl-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 13:09:06 | WBPerson1845 | Event | Created |
| | | | 2 | 05 Oct 2005 17:16:53 | WBPerson2970 | Event | Acquires_merge | WBGene00007157 |
| | | | | | | Name_change | Sequence_name | B0379.4 |
| | | | 3 | 02 Feb 2007 10:26:41 | WBPerson2970 | Name_change | CGC_name | scpl-1 |
| | | | | | | | Other_name | tag-188 |
| | | Acquires_merge | WBGene00007157 |
| | | | WBGene00043085 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | scpl |
| | Allele (181) |
| | Strain | WBStrain00031805 |
| | | WBStrain00035918 |
| | RNASeq_FPKM (74) |
| | GO_annotation (22) |
| | Ortholog (45) |
| | Paralog | WBGene00021629 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00011897 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00018474 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | scpl-1 encodes, by alternative splicing, two protein isoforms of a putative class-C RNA polymerase II (RNAPII) carboxyl-terminal domain (CTD) phosphatase, orthologous to budding yeast PSR1 and PSR2 and human CTDSP1 (OMIM:605323), CTDSP2 (OMIM:608711, amplified in sarcoma), and CTDSPL (OMIM:608592, deleted in epithelial cancer), and paralogous to C. elegans SCPL-3 and human CTDSPL2; more distantly, SCPL-1 (and its paralog SCPL-3) are similar to SCPL-2, SCPL-4, and FCP-1; loss of scpl-1 activity via RNAi results in a slightly abnormal egg-laying response in the presence of serotonin; an scpl-1::gfp promoter fusion is expressed in pharyngeal, vulval, and body wall muscle; within body wall muscle, SCPL-1 localize to the M line and I band; SCPL-1 physically interacts with UNC-89 both in vitro and in vivo. | Paper_evidence | WBPaper00029277 |
| | | | | | WBPaper00029278 |
| | | | | | WBPaper00029279 |
| | | | | | WBPaper00029280 |
| | | | | | WBPaper00031595 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 16 Dec 2011 00:00:00 |
| | | Automated_description | Enables several functions, including LIM domain binding activity; kinase binding activity; and protein-macromolecule adaptor activity. Involved in dephosphorylation and regulation of egg-laying behavior. Located in I band and M band. Expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Is an ortholog of human CTDSP1 (CTD small phosphatase 1) and CTDSPL (CTD small phosphatase like). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16890) |
| Molecular_info | Corresponding_CDS | B0379.4a |
| | | B0379.4b |
| | | B0379.4c |
| | Corresponding_CDS_history | B0379.4:wp77 |
| | | B0379.4a:wp103 |
| | | B0379.4b:wp103 |
| | Corresponding_transcript | B0379.4a.1 |
| | | B0379.4b.1 |
| | | B0379.4c.1 |
| | Other_sequence (38) |
| | Associated_feature (22) |
| | Transcription_factor | WBTranscriptionFactor000636 |
| Experimental_info | RNAi_result (13) |
| | Expr_pattern | Chronogram589 |
| | | Expr8052 |
| | | Expr8053 |
| | | Expr1015780 |
| | | Expr1033029 |
| | | Expr1143160 |
| | | Expr2015647 |
| | | Expr2033879 |
| | Drives_construct | WBCnstr00002821 |
| | | WBCnstr00013080 |
| | Antibody | WBAntibody00001386 |
| | | WBAntibody00001387 |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00033065:isp-1-1(qm150)_upregulated |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_embryo_enriched |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00041075:hcf-1(-)_skn-1(+)_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:tunicamycin_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00057254:MWCNT_downregulated_mRNA |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00061340:ADE |
| | | WBPaper00061340:Arcade_cell_anterior_and_posterior |
| | | WBPaper00061340:OLL |
| | | WBPaper00061527:srj-42-srw-113 |
| | | WBPaper00061527:T23B5.3_15993-C17D12.1 |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062237:dnj-21(RNAi)_upregulated_protein |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | cgc4489_group_4 |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00040184:hcf-1down_sir-2.1down_daf-2down |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction (39) |
| Map_info | Map | I | Position | 4.63311 | Error | 0.019017 |
| | Positive | Positive_clone | B0379 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5541 |
| | | | 5251 |
| | Pseudo_map_position |
| Reference (11) |
| Remark | tag-188 is parsed from CGC strain VC612 |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
