| WBGene00006887 | SMap | S_parent | Sequence | C35B8 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | vav-1 | Person_evidence | WBPerson404 |
| | | Sequence_name | C35B8.2 |
| | | Molecular_name | C35B8.2a |
| | | | C35B8.2a.1 |
| | | | CE38040 |
| | | | C35B8.2b |
| | | | CE39333 |
| | | | C35B8.2c |
| | | | CE53342 |
| | | | C35B8.2b.1 |
| | | | C35B8.2c.1 |
| | | Other_name | CELE_C35B8.2 | Accession_evidence | NDB | BX284606 |
| | | Public_name | vav-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | vav |
| | Allele (258) |
| | Strain | WBStrain00003320 |
| | | WBStrain00035617 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00003931 |
| | | 00003932 |
| | | 00080791 |
| | | 00080792 |
| | | 00080793 |
| | | 00080794 |
| | | 00080795 |
| | | 00080796 |
| | | 00080797 |
| | | 00114965 |
| | Ortholog (48) |
| | Paralog | WBGene00006496 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00006805 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00009337 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00010111 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00010776 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00015704 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | vav-1 encodes a Rho/Rac-family guanine nucleotide exchange factor orthologous to the Vav proto-oncogene; VAV-1 is a complex protein with several domains, from N- to C-terminus: a calponin-like actin-binding domain; a RhoGEF/DH domain; a pleckstrin-like domain; a SH2 motif domain; and an SH3 domain; in C. elegans vav-1 is an essential gene and functions to regulate the concentration of intracellular calcium and thus, plays a key role in regulating rhythmic behaviors such as pharyngeal pumping, ovulation, and defecation; in addition, vav-1 has been shown to be a target of the mir-61 miRNA in the secondary vulval precursor cells, where it functions to negatively regulate LIN-12 activity; VAV-1::GFP reporters are expressed in the pharynx, the contractile sheath cells of the gonad, the four posterior-most intestinal cells, and the three rectal epithelial cells; VAV-1::GFP is also seen in the distal gonad, body wall muscle, and in the vulval precursor cells and their descendants. | Paper_evidence | WBPaper00012852 |
| | | | | | WBPaper00026850 |
| | | | | | WBPaper00026909 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 20 Feb 2009 00:00:00 |
| | | Automated_description | Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of nematode male tail tip morphogenesis; and regulation of vulval development. Predicted to be located in cytoplasm. Expressed in several structures, including gonad; intestinal cell; neurons; pharyngeal cell; and tail hypodermis. Is an ortholog of human VAV1 (vav guanine nucleotide exchange factor 1); VAV2 (vav guanine nucleotide exchange factor 2); and VAV3 (vav guanine nucleotide exchange factor 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info (5) |
| Experimental_info | RNAi_result (17) |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00000019 |
| | | WBCnstr00003791 |
| | | WBCnstr00008160 |
| | | WBCnstr00011643 |
| | | WBCnstr00011704 |
| | | WBCnstr00020222 |
| | | WBCnstr00034113 |
| | Construct_product | WBCnstr00000018 |
| | | WBCnstr00000019 |
| | | WBCnstr00000020 |
| | | WBCnstr00000027 |
| | | WBCnstr00011643 |
| | | WBCnstr00014782 |
| | | WBCnstr00019921 |
| | | WBCnstr00019932 |
| | | WBCnstr00020222 |
| | | WBCnstr00034113 |
| | Microarray_results (26) |
| | Expression_cluster | WBPaper00032425:up_in_alg-1 |
| | | WBPaper00032425:up_in_lin-35 |
| | | WBPaper00032425:up_in_zfp-1 |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set2 |
| | | WBPaper00048644:germline_enriched |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056034:pals-25(jy9)_downregulated |
| | | WBPaper00056139:gut-microbiota_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061340:ABarpaaa_lineage |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:AMso_parent |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:mc1 |
| | | WBPaper00061340:mc3 |
| | | WBPaper00061340:Neuroblast_AFD_RMD |
| | | WBPaper00061340:Parents_of_PHsh_hyp8_hyp9 |
| | | WBPaper00061340:Parent_of_AMsh_URB |
| | | WBPaper00061340:Parent_of_hyp3_ILsoDx |
| | | WBPaper00061340:Pharyngeal_marginal_cell |
| | | WBPaper00061340:pm3_pm4_pm5 |
| | | WBPaper00061340:pm7 |
| | | WBPaper00061340:rect_D |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061527:hlh-30_18579-unc-43_21739 |
| | | WBPaper00061527:utx-1_2886-swan-1_2192 |
| | | WBPaper00062520:qui-1(db104)_downregulated |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065841:139_0 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | cgc4489_group_7 |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030985:Erwinia_carotovora_downregulated |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040963:TA200_up |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00055899:nitroguanidine_regulated |
| | Interaction (113) |
| | WBProcess | WBbiopr:00000044 |
| | | WBbiopr:00000053 |
| | | WBbiopr:00000120 |
| Map_info | Map | X | Position | 0.858443 | Error | 0.015966 |
| | Positive | Positive_clone | C35B8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4774 |
| | | | 4378 |
| | Pseudo_map_position |
| Reference (27) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
