| WBGene00006381 | SMap | S_parent | Sequence | Y54E2A |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | tac-1 | Person_evidence | WBPerson208 |
| | | Sequence_name | Y54E2A.3 |
| | | Molecular_name | Y54E2A.3 |
| | | | Y54E2A.3.1 |
| | | | CE20302 |
| | | Other_name | 2P40 | Accession_evidence | EMBL | AF326937 |
| | | | CELE_Y54E2A.3 | Accession_evidence | NDB | BX284602 |
| | | Public_name | tac-1 |
| | DB_info | Database | AceView | gene | 2P38 |
| | | | WormQTL | gene | WBGene00006381 |
| | | | WormFlux | gene | WBGene00006381 |
| | | | NDB | locus_tag | CELE_Y54E2A.3 |
| | | | NCBI | gene | 175133 |
| | | | RefSeq | protein | NM_064658.8 |
| | | | SwissProt | UniProtAcc | G5ECG0 |
| | | | UniProt_GCRP | UniProtAcc | G5ECG0 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | tac |
| | Allele (20) |
| | Strain | WBStrain00037424 |
| | | WBStrain00007335 |
| | | WBStrain00007333 |
| | | WBStrain00050672 |
| | RNASeq_FPKM (74) |
| | GO_annotation (46) |
| | Contained_in_operon | CEOP2648 |
| | Ortholog (20) |
| | Structured_description | Concise_description | tac-1 encodes the sole C. elegans member of the transforming acidic coiled-coil (TACC) protein family whose members contain highly conserved C-terminal coiled-coil domains; during early embryogenesis, TAC-1 activity is essential for such microtubule-based processes as pronuclear migration and mitotic spindle elongation; TAC-1 interacts in vivo with, and mutually stabilizes, ZYG-9, a microtubule-associated protein (MAP) also required for pronuclear migration; TAC-1 also interacts with ZYG-8, a kinase domain-containing MAP required for proper spindle positioning during anaphase of the first embryonic cell division; TAC-1 is a core component of centrosomes, and also localizes to the meiotic spindle poles, the mitotic spindle, and the cytoplasm. | Paper_evidence | WBPaper00006059 |
| | | | | | WBPaper00006060 |
| | | | | | WBPaper00006061 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Mar 2006 00:00:00 |
| | | Automated_description | Enables protein domain specific binding activity. Involved in several processes, including regulation of microtubule polymerization or depolymerization; sexual reproduction; and spindle organization. Located in cytoplasm; kinetochore; and microtubule cytoskeleton. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | Y54E2A.3 |
| | Corresponding_transcript | Y54E2A.3.1 |
| | Other_sequence | AF326937 |
| | | FG620567.1 |
| | Associated_feature | WBsf650765 |
| | | WBsf224306 |
| Experimental_info | RNAi_result (18) |
| | Expr_pattern | Expr2681 |
| | | Expr2683 |
| | | Expr2684 |
| | | Expr2685 |
| | | Expr12439 |
| | | Expr1020108 |
| | | Expr1032578 |
| | | Expr1160809 |
| | | Expr2017202 |
| | | Expr2035338 |
| | Construct_product | WBCnstr00005024 |
| | | WBCnstr00010900 |
| | | WBCnstr00015616 |
| | | WBCnstr00015617 |
| | | WBCnstr00020876 |
| | | WBCnstr00021102 |
| | | WBCnstr00022253 |
| | | WBCnstr00022255 |
| | | WBCnstr00022258 |
| | | WBCnstr00040176 |
| | Antibody | WBAntibody00000668 |
| | | WBAntibody00000669 |
| | | WBAntibody00000670 |
| | | WBAntibody00002182 |
| | | WBAntibody00002963 |
| | | WBAntibody00003043 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050514:CEBP-1_interacting |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053295:lin-22(ot267)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053388:dauer_regulated_Cluster6 |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060951:mrpl-2(osa3)_upregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061340:Parent_of_AMsh_URB |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:pbs-3_18439-rpn-5 |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061692:acivicin_downregulated |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062293:isp-1(qm150)_downregulated |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064789:Day6_vs_Day1_upregulated_neuron |
| | | WBPaper00064789:Day9_vs_Day1_upregulated_neuron |
| | | WBPaper00064871:hypoxia_upregulated_F1 |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_upregulated_Ref |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066085:sin-3(syb2172)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_6_1 |
| | | cgc4489_group_1 |
| | | WBPaper00025032:cluster_62 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026952:class_A |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_7 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00040963:TA200_down |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(143_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:intrinsic |
| | Interaction (152) |
| Map_info | Map | II | Position | 23.4578 | Error | 0.010609 |
| | Positive | Positive_clone | Y54E2A | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (35) |
| Remark (2) |
| Method | Gene |
