WormBase Tree Display for Gene: WBGene00004992

WBGene00004992 Evidence: Author_evidence (2)
  SMap: S_parent: Sequence: ZK616
  Identity: Version: 1
    Name: CGC_name: spp-7
      Sequence_name: ZK616.9
      Molecular_name: ZK616.9a
        ZK616.9a.1
        CE26344
        ZK616.9b
        CE49425
        ZK616.9b.1
      Other_name: ZK616.b Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_ZK616.9 Accession_evidence: NDB BX284604
      Public_name: spp-7
    DB_info: Database: AceView gene 4G178
        WormQTL gene WBGene00004992
        WormFlux gene WBGene00004992
        NDB locus_tag CELE_ZK616.9
        Panther gene CAEEL|WormBase=WBGene00004992|UniProtKB=V6CM12
          family PTHR11480
        NCBI gene 177326
        RefSeq protein NM_068407.5
            NM_001306908.4
        TrEMBL UniProtAcc Q9N4M7
            V6CM12
        UniProt_GCRP UniProtAcc V6CM12
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:37 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: spp
    Allele (27)
    RNASeq_FPKM (74)
    Ortholog (29)
    Paralog: WBGene00004993 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004995 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004998 Caenorhabditis elegans From_analysis: Panther
      WBGene00005000 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: spp-7 encodes an antimicrobial peptide that belongs to the SPP-protein family, called caenopores, with structural similarity to saposin-like proteins (SAPLIPs), the amoebapores and the mammalian NK-lysin and granulysin; caenopores are part of the worm's innate immune system and interact with and eliminate bacteria via membrane pore-forming activity; C. elegans has at least 33 putative SPP proteins; promoter-gfp studies indicate that spp-7 is expressed in pharyngeal muscle, head neurons and the intestine. Paper_evidence: WBPaper00029438
            WBPaper00035289
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Sep 2013 00:00:00
      Automated_description: Expressed in head neurons; intestine; and pm7. Is predicted to encode a protein with the following domains: Saposin B type domain; Saposin-like type B, region 2; and Saposin-like. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK616.9a
      ZK616.9b
    Corresponding_transcript: ZK616.9a.1
      ZK616.9b.1
    Other_sequence (13)
    Associated_feature: WBsf651801
      WBsf996501
      WBsf1017381
      WBsf230088
  Experimental_info: RNAi_result: WBRNAi00000717 Inferred_automatically: RNAi_primary
      WBRNAi00038362 Inferred_automatically: RNAi_primary
      WBRNAi00059557 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4719
      Expr1026928
      Expr1162973
      Expr2016085
      Expr2034321
    Drives_construct: WBCnstr00012196
      WBCnstr00015889
      WBCnstr00035285
    Construct_product: WBCnstr00012196
      WBCnstr00035285
    Microarray_results (16)
    Expression_cluster: WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040420:ALM_PLM_enriched
      WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray
      WBPaper00042561:smg-2(RNAi)_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044786:emr-1(gk119)_upregulated
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045050:csr-1(hypomorph)_upregulated
      WBPaper00045257:bar-1(ga80)_downregulated
      WBPaper00045420:fertilization_upregulated_transcript
      WBPaper00049377:MWCNT_downregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053402:cco-1(RNAi)_downregulated
      WBPaper00053771:down_by_skn-1(RNAi)_at_dpy-7(e88)
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053888:drh-3(rrr2)_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055013:hmg-4(RNAi)_downregulated
      WBPaper00055013:spt-16(RNAi)_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055941:nuo-6(qm200)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056169:rrf-3(pk1426)_downregulated_L3
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056169:rrf-3(pk1426)_upregulated_L2
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_L1
      WBPaper00059739:hira-1(gk835598)_downregulated_L4
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060909:atfs-1(et18)_downregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:Anterior_arcade_cell
      WBPaper00061340:g1A_g1P
      WBPaper00061340:g1P
      WBPaper00061340:MC
      WBPaper00061340:pm1_pm2
      WBPaper00061340:pm7
      WBPaper00061340:pm8
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061527:C38C6.3-acdh-6
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00062118:neural-HSF-1_downregulated
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062456:doxycycline_upregulated_N2_transcript
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065005:sams-3(RNAi)_upregulated
      WBPaper00065005:sams-4(RNAi)_upregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065560:E.coli-HB101_downregulated_F3
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_upregulated_WT
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032948:FedUp
      WBPaper00032948:MoltOssilate
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00038172:crh-1null_down_regulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045437:Toxic-Se_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00046083:oga-1(ok1207)_OP50_downregulated
      WBPaper00046083:ogt-1(ok1474)_OP50_downregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
    Interaction: WBInteraction000503638
  Map_info: Map: IV Position: 1.65867 Error: 0.001692
    Positive: Positive_clone: ZK616 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00024209
    WBPaper00029438
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene