WormBase Tree Display for Gene: WBGene00004801

WBGene00004801 SMap: S_parent: Sequence: F46G10
  Identity: Version: 1
    Name: CGC_name: sir-2.2 Person_evidence: WBPerson1840
      Sequence_name: F46G10.7
      Molecular_name (11)
      Other_name: CELE_F46G10.7 Accession_evidence: NDB BX284606
      Public_name: sir-2.2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sir
    Allele (77)
    Strain: WBStrain00047283
    RNASeq_FPKM (74)
    GO_annotation (19)
    Contained_in_operon: CEOPX178
      CEOP2736
    Ortholog (31)
    Paralog: WBGene00004802 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00004800 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004803 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sir-2.2 encodes one of four C. elegans proteins with similarity to the Saccharomyces cerevisiae Sir2p NAD-dependent histone deacetylase; SIR-2.2 may play a role in genomic stability and protecting the genome against mutations, as loss of SIR-2.2 function via RNA-mediated interference (RNAi) results in an increased level of spontaneous mutagenesis. Paper_evidence: WBPaper00004566
            WBPaper00005736
          Curator_confirmed: WBPerson1843
          Date_last_updated: 11 May 2009 00:00:00
      Automated_description: Predicted to enable NAD+ binding activity and NAD-dependent histone deacetylase activity. Involved in innate immune response. Located in mitochondrion. Is an ortholog of human SIRT4 (sirtuin 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F46G10.7a
      F46G10.7b
      F46G10.7c
    Corresponding_CDS_history: F46G10.7:wp109
    Corresponding_transcript: F46G10.7a.1
      F46G10.7a.2
      F46G10.7b.1
      F46G10.7b.2
      F46G10.7c.1
    Other_sequence (15)
    Associated_feature: WBsf648660
      WBsf236559
  Experimental_info: RNAi_result (7)
    Expr_pattern: Chronogram1178
      Expr6092
      Expr6093
      Expr10774
      Expr1027681
      Expr1151410
      Expr1200185
      Expr2015824
      Expr2034057
    Drives_construct: WBCnstr00003470
      WBCnstr00003833
      WBCnstr00017540
      WBCnstr00035380
    Construct_product: WBCnstr00017540
      WBCnstr00017950
      WBCnstr00035380
    Antibody: WBAntibody00002427
    Microarray_results (27)
    Expression_cluster: WBPaper00029359_1166
      WBPaper00029359_1197
      WBPaper00029359_1291
      WBPaper00029359_1320
      WBPaper00029359_1326
      WBPaper00029359_1345
      WBPaper00029359_1439
      WBPaper00029359_1458
      WBPaper00029359_1546
      WBPaper00029359_1549
      WBPaper00029359_1557
      WBPaper00029359_1599
      WBPaper00029359_1618
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:dopaminergic-neurons_embryo_enriched
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00048923:Aging_regulated
      WBPaper00048988:daf-2(e1370)_downregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058711:paraquat_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00061203:let-418(n3536)_downregulated
      WBPaper00061340:Rectal_cell
      WBPaper00061527:ccg-1_12351-ZC410.5
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_7
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028482:PA14_upregulated
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00032062:age_regulated_genes
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036286:Pattern_I
      WBPaper00038304:octr-1_regulated
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00055899:nitroguanidine_regulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
      [cgc6390]:herm_soma-enriched
    SAGE_tag: SAGE:taatcttgaa Strand: Antisense
      SAGE:atggataaac Strand: Antisense
      SAGE:aaacaaattgccattct Strand: Antisense
      SAGE:aagttccgtt Strand: Antisense
      SAGE:aaacaaattg Strand: Antisense
      SAGE:gcgacgatga Strand: Sense
        Unambiguously_mapped
      SAGE:ccatacttca Strand: Antisense
      SAGE:gcgacgatgaagttaga Strand: Sense
        Unambiguously_mapped
      SAGE:ttaacgttct Strand: Antisense
    Interaction (150)
  Map_info: Map: X Position: 11.3226 Error: 0.035645
    Positive: Positive_clone: F46G10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (13)
  Remark: Sequence connection from [Tissenbaum HA]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene