WormBase Tree Display for Gene: WBGene00004800
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| WBGene00004800 | SMap | S_parent | Sequence | R11A8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sir-2.1 | Person_evidence | WBPerson1840 | |||||
| Sequence_name | R11A8.4 | ||||||||
| Molecular_name | R11A8.4a | ||||||||
| R11A8.4a.1 | |||||||||
| CE06302 | |||||||||
| R11A8.4b | |||||||||
| CE44629 | |||||||||
| R11A8.4b.1 | |||||||||
| Other_name | CELE_R11A8.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | sir-2.1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sir | ||||||||
| Allele (42) | |||||||||
| Strain | WBStrain00024177 | ||||||||
| WBStrain00022167 | |||||||||
| WBStrain00026544 | |||||||||
| WBStrain00035578 | |||||||||
| WBStrain00047283 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Contained_in_operon | CEOP4372 | ||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00014769 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | |||||
| WBGene00004801 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00004802 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00004803 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | sir-2.1 encodes an NAD-dependent protein deacetylase with similarity to Saccharomyces cerevisiae Sir2p and mammalian SIRT1. | Paper_evidence | WBPaper00004566 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 14 Nov 2014 00:00:00 | ||||||||
| Automated_description | Enables deacetylase activity. Involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage. Located in chromosome, telomeric region; nucleus; and perinuclear region of cytoplasm. Expressed in several structures, including intestinal cell; neurons; retrovesicular ganglion; tail; and ventral nerve cord. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; non-alcoholic fatty liver disease; and senile cataract. Is an ortholog of human SIRT1 (sirtuin 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00041098 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 May 2019 00:00:00 | ||||||||
| Potential_model | DOID:9669 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14929) | |||||
| DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14929) | ||||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14929) | ||||||
| DOID:4448 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14929) | ||||||
| DOID:0080208 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14929) | ||||||
| DOID:1826 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14929) | ||||||
| Models_disease_asserted | WBDOannot00000675 | ||||||||
| Molecular_info | Corresponding_CDS | R11A8.4a | |||||||
| R11A8.4b | |||||||||
| Corresponding_transcript | R11A8.4a.1 | ||||||||
| R11A8.4b.1 | |||||||||
| Other_sequence (27) | |||||||||
| Associated_feature | WBsf652127 | ||||||||
| WBsf230722 | |||||||||
| WBsf230723 | |||||||||
| WBsf230724 | |||||||||
| Experimental_info | RNAi_result (22) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct (18) | |||||||||
| Construct_product (18) | |||||||||
| Regulate_expr_cluster (22) | |||||||||
| Antibody | WBAntibody00001101 | ||||||||
| WBAntibody00001123 | |||||||||
| WBAntibody00001697 | |||||||||
| WBAntibody00001698 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (97) | |||||||||
| Interaction (156) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000121 | |||||||||
| Map_info | Map | IV | Position | 4.57839 | Error | 0.000393 | |||
| Positive | Positive_clone | R11A8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4660 | |||||||
| Pseudo_map_position | |||||||||
| Reference (245) | |||||||||
| Remark | Sequence connection from [Tissenbaum HA] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
