WormBase Tree Display for Gene: WBGene00004800

WBGene00004800 SMap: S_parent: Sequence: R11A8
  Identity: Version: 1
    Name: CGC_name: sir-2.1 Person_evidence: WBPerson1840
      Sequence_name: R11A8.4
      Molecular_name: R11A8.4a
        R11A8.4a.1
        CE06302
        R11A8.4b
        CE44629
        R11A8.4b.1
      Other_name: CELE_R11A8.4 Accession_evidence: NDB BX284604
      Public_name: sir-2.1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sir
    Allele (42)
    Strain: WBStrain00024177
      WBStrain00022167
      WBStrain00026544
      WBStrain00035578
      WBStrain00047283
    RNASeq_FPKM (74)
    GO_annotation (36)
    Contained_in_operon: CEOP4372
    Ortholog (42)
    Paralog: WBGene00014769 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
      WBGene00004801 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004802 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004803 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sir-2.1 encodes an NAD-dependent protein deacetylase with similarity to Saccharomyces cerevisiae Sir2p and mammalian SIRT1. Paper_evidence: WBPaper00004566
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 14 Nov 2014 00:00:00
      Automated_description: Enables deacetylase activity. Involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage. Located in chromosome, telomeric region; nucleus; and perinuclear region of cytoplasm. Expressed in several structures, including intestinal cell; neurons; retrovesicular ganglion; tail; and ventral nerve cord. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; non-alcoholic fatty liver disease; and senile cataract. Is an ortholog of human SIRT1 (sirtuin 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00041098
          Curator_confirmed: WBPerson324
          Date_last_updated: 21 May 2019 00:00:00
    Potential_model: DOID:9669 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:12858 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:4448 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:0080208 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
      DOID:1826 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14929)
  Models_disease_asserted: WBDOannot00000675
  Molecular_info: Corresponding_CDS: R11A8.4a
      R11A8.4b
    Corresponding_transcript: R11A8.4a.1
      R11A8.4b.1
    Other_sequence (27)
    Associated_feature: WBsf652127
      WBsf230722
      WBsf230723
      WBsf230724
  Experimental_info: RNAi_result (22)
    Expr_pattern (11)
    Drives_construct (18)
    Construct_product (18)
    Regulate_expr_cluster (22)
    Antibody: WBAntibody00001101
      WBAntibody00001123
      WBAntibody00001697
      WBAntibody00001698
    Microarray_results (26)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:isp-1-1(qm150)_upregulated
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_downregulated_N2
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050015:ifg-1(RNAi)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00054626:NO_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059763:neuron_expressed
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00061340:Neuroblast_AFD_RMD
      WBPaper00061340:RIA_parent
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:skr-16-F37B4.10
      WBPaper00061572:oleic-acid-specific_mating_upregulated
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064716:paraquat_upregulated
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_7
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00036286:Pattern_B
      WBPaper00036286:Pattern_H
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00044091:Bpseudomallei_induced_12h
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:herm_sex-enriched
    Interaction (156)
    WBProcess: WBbiopr:00000001
      WBbiopr:00000121
  Map_info: Map: IV Position: 4.57839 Error: 0.000393
    Positive: Positive_clone: R11A8 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4660
    Pseudo_map_position
  Reference (245)
  Remark: Sequence connection from [Tissenbaum HA]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene