| WBGene00004324 | SMap | S_parent | Sequence | F21C3 |
|---|
| Identity | Version | 3 |
| | Name | CGC_name | rde-2 | Person_evidence | WBPerson419 |
| | | Sequence_name | F21C3.4 |
| | | Molecular_name | F21C3.4a |
| | | | F21C3.4a.1 |
| | | | CE37005 |
| | | | F21C3.4b |
| | | | CE38174 |
| | | | F21C3.4b.1 |
| | | Other_name | mut-8 | Paper_evidence | WBPaper00003956 |
| | | | | Person_evidence | WBPerson2587 |
| | | | CELE_F21C3.4 | Accession_evidence | NDB | BX284601 |
| | | Public_name | rde-2 |
| | DB_info | Database | WormQTL | gene | WBGene00004324 |
| | | | WormFlux | gene | WBGene00004324 |
| | | | NDB | locus_tag | CELE_F21C3.4 |
| | | | NCBI | gene | 172473 |
| | | | RefSeq | protein | NM_001026227.3 |
| | | | | | NM_001026228.4 |
| | | | TrEMBL | UniProtAcc | Q19672 |
| | | | | | Q58AA4 |
| | | | UniProt_GCRP | UniProtAcc | Q19672 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 14 Jan 2005 10:37:35 | WBPerson2970 | Event | Acquires_merge | WBGene00003505 |
| | | | 3 | 14 Jan 2005 10:41:26 | WBPerson2970 | Event | Acquires_merge | WBGene00009003 |
| | | Acquires_merge | WBGene00003505 |
| | | | WBGene00009003 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | rde |
| | Allele (31) |
| | Strain | WBStrain00029016 |
| | | WBStrain00040416 |
| | RNASeq_FPKM (74) |
| | GO_annotation (9) |
| | Contained_in_operon | CEOP1384 |
| | Ortholog (20) |
| | Structured_description | Concise_description | rde-2 encodes a novel protein that is conserved in at least two other Caenorhabditis species; rde-2 is required for the functional silencing of chromosomal loci by transgenes (cosuppression) and promotes the effects of RNAi in a step after the formation of a heritable interfering agent, also affects X-chromosome nondisjunction and transposon activation; functions downstream of rde-1 in the RNAi pathway most effective against germline, but not somatically expressed, genes; RDE-2 is present predominantly in the cytosol, in complexes with MUT-7, a predicted exoribonuclease also required for RNA interference. | Paper_evidence | WBPaper00003711 |
| | | | | | WBPaper00003964 |
| | | | | | WBPaper00004198 |
| | | | | | WBPaper00005368 |
| | | | | | WBPaper00024699 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson1843 |
| | | | | Date_last_updated | 22 Feb 2006 00:00:00 |
| | | Automated_description | Involved in several processes, including meiotic chromosome segregation and regulatory ncRNA-mediated gene silencing. Located in cytosol and mutator focus. Expressed in germ line. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F21C3.4a |
| | | F21C3.4b |
| | Corresponding_CDS_history | F21C3.4:wp47 |
| | | F21C3.4:wp128 |
| | Corresponding_transcript | F21C3.4a.1 |
| | | F21C3.4b.1 |
| | Other_sequence | CBC00924_1 |
| | Associated_feature | WBsf219729 |
| | | WBsf219730 |
| Experimental_info | RNAi_result | WBRNAi00086733 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00003411 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061788 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00003412 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00092968 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00076321 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00086728 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00031209 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00116531 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00045182 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr10156 |
| | | Expr1018003 |
| | | Expr1032149 |
| | | Expr1149122 |
| | | Expr2015285 |
| | | Expr2033519 |
| | Drives_construct | WBCnstr00014701 |
| | | WBCnstr00014703 |
| | Construct_product | WBCnstr00014701 |
| | | WBCnstr00014703 |
| | Antibody | WBAntibody00000829 |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00055354:Allantoin_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00060911:prx-5(RNAi)_upregulated_protein |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061274:hypergravity_15xg_upregulated |
| | | WBPaper00061340:Neuroblast_I6_M5 |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061527:F31C3.4_6048-cutc-1_15804 |
| | | WBPaper00061527:pch-2-B0393.3 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_2 |
| | | cgc4489_group_6 |
| | | WBPaper00025032:cluster_19 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00029437:dcr-1_downregulated |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036130:mir-243_down_regulated |
| | | WBPaper00036286:Pattern_B |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | [cgc5767]:cluster_3 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(23_min) |
| | | [cgc5767]:expression_class_SM |
| | | [cgc5767]:expression_class_SMD |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (33) |
| Map_info | Map | I | Position | 1.87282 | Error | 0.000485 |
| | Positive | Positive_clone | F21C3 | Inferred_automatically | From From sequence, transcript, pseudogene data |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5087 |
| | | | 4953 |
| | | | 5331 |
| | Pseudo_map_position |
| Reference (51) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
