| WBGene00004321 | SMap | S_parent | Sequence | F54E7 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | rcan-1 | Paper_evidence | WBPaper00048397 |
| | | | | Person_evidence | WBPerson746 |
| | | Sequence_name | F54E7.7 |
| | | Molecular_name | F54E7.7 |
| | | | F54E7.7.1 |
| | | | CE31002 |
| | | Other_name | DSCR1L | Accession_evidence | EMBL | AF176115 |
| | | | SC | Accession_evidence | EMBL | AF176115 |
| | | | rcn-1 | Paper_evidence | WBPaper00005829 |
| | | | | Person_evidence | WBPerson746 |
| | | | CELE_F54E7.7 | Accession_evidence | NDB | BX284603 |
| | | Public_name | rcan-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 03 Sep 2015 10:04:07 | WBPerson2970 | Name_change | CGC_name | rcan-1 |
| | | | | | | | Other_name | rcn-1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | rcan |
| | Allele (25) |
| | RNASeq_FPKM (74) |
| | GO_annotation (18) |
| | Ortholog (43) |
| | Structured_description | Automated_description | Enables protein phosphatase 2B binding activity and protein serine/threonine phosphatase inhibitor activity. Involved in several processes, including male mating behavior; positive regulation of nematode male tail tip morphogenesis; and thermosensory behavior. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including non-striated muscle; pharyngeal cell; somatic nervous system; tail; and vulva. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human RCAN1 (regulator of calcineurin 1); RCAN2 (regulator of calcineurin 2); and RCAN3 (RCAN family member 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:14250 | Homo sapiens | Paper_evidence | WBPaper00005829 |
| | | | | Accession_evidence | OMIM | 190685 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 05 Jun 2017 00:00:00 |
| | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3040) |
| | Disease_relevance | DSCR1) gene is located in the Down Syndrome critical region (DSCR) of chromosome 21, and encodes an inhibitor of calcineurin-signalling pathways; in elegans, overexpression of rcan-1 could reproduce calcineurin loss-of-function phenotypes, providing in vivo proof of rcan-1 regulation of calcineurin; also, as with mbk-1, another DSCR gene ortholog in elegans, adjusting rcan-1 dosage could reverse the effects of its overexpression. | Homo sapiens | Paper_evidence | WBPaper00005829 |
| | | | | Accession_evidence | OMIM | 190685 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 05 Jun 2017 00:00:00 |
| Models_disease_in_annotation | WBDOannot00000131 |
| Molecular_info (4) |
| Experimental_info | RNAi_result | WBRNAi00048353 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00015642 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00005533 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027915 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr2548 |
| | | Expr11062 |
| | | Expr13659 |
| | | Expr1011498 |
| | | Expr1032146 |
| | | Expr1152149 |
| | | Expr2015278 |
| | | Expr2033512 |
| | Drives_construct | WBCnstr00008158 |
| | | WBCnstr00010850 |
| | | WBCnstr00037927 |
| | | WBCnstr00039931 |
| | Construct_product | WBCnstr00008158 |
| | | WBCnstr00037927 |
| | | WBCnstr00039931 |
| | Antibody | WBAntibody00002649 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00032528:L3_enriched |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:BAG-neuron_embryo_enriched |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:excretory-cell_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045050:csr-1(hypomorph)_downregulated |
| | | WBPaper00045314:S.aureus-induced_N2 |
| | | WBPaper00045316:prg-1_upregulated_L1 |
| | | WBPaper00045316:prg-1_upregulated_L2 |
| | | WBPaper00045316:prg-1_upregulated_L3 |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h |
| | | WBPaper00047132:glp-1(ts)-25C_upregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(+) |
| | | WBPaper00050053:muscle_enriched_Day4 |
| | | WBPaper00050094:mes-2(bn11)_upregulated |
| | | WBPaper00050094:mes-6(bn66)_upregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050448:KGB-1-induced |
| | | WBPaper00050468:hlh-30-dependent_Cry5B_regulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050514:CEBP-1_interacting |
| | | WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_nucleus_expressed |
| | | WBPaper00051257:Levamisole_upregulated |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00053664:ins-11(tm1053)_upregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056034:pals-25(jy9)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057068:Cadmium_upregulated |
| | | WBPaper00057162:meg-3_meg-4_upregulated_sRNA |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00060951:mrpl-2(osa3)_downregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061274:microgravity_downregulated |
| | | WBPaper00061340:AIN |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:AVK |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:FLP |
| | | WBPaper00061340:PVT |
| | | WBPaper00061340:RIM |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061479:hda-1(ne4748)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:snt-4_17845-T27C4.1 |
| | | WBPaper00061651:ASG_enriched |
| | | WBPaper00061651:AVG_enriched |
| | | WBPaper00061651:BAG_enriched |
| | | WBPaper00061651:PLM_enriched |
| | | WBPaper00061651:PVT_enriched |
| | | WBPaper00061651:RIB_enriched |
| | | WBPaper00061651:RIS_enriched |
| | | WBPaper00061651:SMB_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062520:qui-1(db104)_upregulated |
| | | WBPaper00062590:Aging_upregulated_neuron |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2 |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4386_cluster_3_4 |
| | | cgc4489_group_13 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00028948:cep-1(gk138)_upregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00034757:up_by_oxidative_stress |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00038231:Cry5B_1.5-fold_upregulated |
| | | WBPaper00038231:Cry5B_2-fold_upregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotype_environment_interaction |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | | WBPaper00045015:nhr-25(RNAi)_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(143_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(143_min) |
| | | [cgc6390]:Cluster_A |
| | Interaction (169) |
| Map_info | Map | III | Position | -1.45588 | Error | 0.000648 |
| | Positive | Positive_clone | F54E7 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5250 |
| | | | 5049 |
| | Pseudo_map_position |
| Reference (25) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
