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WormBase Tree Display for Gene: WBGene00004185

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Name Class

WBGene00004185SMapS_parentSequenceR166
IdentityVersion1
NameCGC_namepro-1Person_evidenceWBPerson275
Sequence_nameR166.4
Molecular_nameR166.4
R166.4.1
CE03583
Other_nameCELE_R166.4Accession_evidenceNDBBX284602
Public_namepro-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:34WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpro
Allele (45)
StrainWBStrain00007707
RNASeq_FPKM (74)
GO_annotation (19)
Contained_in_operonCEOP2492
Ortholog (32)
Structured_descriptionConcise_descriptionpro-1 encodes a WD-repeat-containing protein that is orthologous to Saccharomyces cerevisiae IPI3; pro-1 activity is required for ribosome biogenesis and specifically, for efficient processing of intervening sequence 2 (ITS2) from rRNA intermediates during 26S rRNA maturation; during development, pro-1 is essential for larval growth, fertility, and normal cell division patterns; in addition, pro-1 is required cell autonomously in the somatic gonad for proper spatial and temporal regulation of germline development and proliferation; a pro-1 promoter::gfp fusion construct reveals that pro-1 is widely expressed in the embryo as well as in every major post-embryonic lineage including the somatic gonad.Paper_evidenceWBPaper00005654
WBPaper00006395
WBPaper00006484
WBPaper00028280
Curator_confirmedWBPerson1843
Date_last_updated01 Aug 2006 00:00:00
Automated_descriptionInvolved in germ cell development; gonad development; and rRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of Rix1 complex and nuclear pre-replicative complex. Expressed widely. Is an ortholog of human WDR18 (WD repeat domain 18).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSR166.4
Corresponding_transcriptR166.4.1
Other_sequence (37)
Associated_featureWBsf650505
WBsf989377
WBsf989378
WBsf223807
Experimental_infoRNAi_result (19)
Expr_patternExpr2932
Expr1021028
Expr1032045
Expr1155642
Expr2015103
Expr2033341
Drives_constructWBCnstr00001236
WBCnstr00011026
WBCnstr00035649
Construct_productWBCnstr00011026
WBCnstr00035649
Microarray_results (19)
Expression_clusterWBPaper00028451:Low_abundance_spermatogenesis_enriched
WBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:bodywall-muscle_larva_enriched
WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00040560:hpl-2_embryo_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00045774:clk-1_downregulated
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00048910:mRNA-interacting_protein
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050496:unc-39(hp701)_regulated
WBPaper00050686:glp-1(e2141)_downregulated
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_nucleus_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051245:nucleus_specific
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053599:oocyte_vs_mitosis_upregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00053810:isp-1(qm150)_downregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055565:AVK_enriched
WBPaper00055648:germline_expressed
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056997:NMAD-1_interacting
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059598:HeatShock_downregulated
WBPaper00060014:set-2(zr2012)_upregulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00061285:wounding_24h_downregulated
WBPaper00061340:Neuroblast_I6_M5
WBPaper00061340:Neuroblast_M2_M3
WBPaper00061341:28C_24h_downregulated
WBPaper00061527:ZK792.5-T26G10.1
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062498:PPM-1.D_interacting
WBPaper00062590:Aging_upregulated_body-wall-muscle
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064315:mes-3(bn199)_downregulated_EGCs
WBPaper00064315:mes-4(bn73)_downregulated_EGCs
WBPaper00064494:postdauer_downregulated_AWA
WBPaper00064716:paraquat_upregulated
WBPaper00065975:P-body_vs_oocyte_enriched
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4489_group_2
cgc4489_group_6
WBPaper00025032:cluster_12
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00032165:differentially_expressed_with_age_medoid_2
WBPaper00034739:N2moreDR1350
WBPaper00035905:FBF-1_Associated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_H
WBPaper00036429:glp-1(oz112)_upregulated
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00041002:HF_3d_2.0mM_Down
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00047070:DAF-16-dependent_UV_response
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00053236:daf-16(mgDF50)_regulated_Starved
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(122_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc6390]:intrinsic
Interaction (79)
Map_infoPositivePositive_cloneR166Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point (3)
Pos_neg_data10741
10742
10743
10744
Interpolated_map_positionII3.07684
Reference (14)
MethodGene