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WormBase Tree Display for Gene: WBGene00004002

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Name Class

WBGene00004002SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_namepgp-8Person_evidenceWBPerson490
Sequence_nameT21E8.3
Molecular_nameT21E8.3
T21E8.3.1
CE31624
Other_nameCELE_T21E8.3Accession_evidenceNDBBX284606
Public_namepgp-8
DB_infoDatabaseAceViewgeneXL480
WormQTLgeneWBGene00004002
WormFluxgeneWBGene00004002
NDBlocus_tagCELE_T21E8.3
PanthergeneCAEEL|WormBase=WBGene00004002|UniProtKB=G5EG03
familyPTHR24221
NCBIgene181277
RefSeqproteinNM_077410.6
TrEMBLUniProtAccG5EG03
UniProt_GCRPUniProtAccG5EG03
OMIMgene171050
171060
603201
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpgp
Allele (100)
StrainWBStrain00001121
WBStrain00032601
RNASeq_FPKM (74)
GO_annotation (12)
Ortholog (50)
Paralog (23)
Structured_descriptionConcise_descriptionpgp-8 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-8 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-8 activity via RNAi results in no obvious defects, the precise role of PGP-8 in C. elegans development and/or behavior is not yet known; pgp-8 promoter-gfp fusion proteins are expressed in adult head neurons.Paper_evidenceWBPaper00006421
WBPaper00024561
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated07 Mar 2006 00:00:00
Automated_descriptionPredicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Expressed in head neurons. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (41)
Molecular_infoCorresponding_CDST21E8.3
Corresponding_CDS_historyT21E8.3:wp83
Corresponding_transcriptT21E8.3.1
Other_sequence (5)
Associated_featureWBsf671000
WBsf237902
Experimental_infoRNAi_resultWBRNAi00053751Inferred_automaticallyRNAi_primary
WBRNAi00035767Inferred_automaticallyRNAi_primary
WBRNAi00077358Inferred_automaticallyRNAi_primary
WBRNAi00070100Inferred_automaticallyRNAi_primary
WBRNAi00018984Inferred_automaticallyRNAi_primary
Expr_patternChronogram1650
Expr3333
Expr3334
Expr1017136
Expr1157298
Expr2014875
Expr2033110
Drives_constructWBCnstr00002004
WBCnstr00011329
WBCnstr00011330
WBCnstr00035748
Construct_productWBCnstr00016458
WBCnstr00035748
Microarray_results (18)
Expression_clusterWBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:AVA-neuron_embryo_enriched
WBPaper00037950:AVA-neuron_embryo_SelectivelyEnriched
WBPaper00037950:bodywall-muscle_larva_enriched
WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched
WBPaper00037950:GABAergic-motor-neurons_larva_enriched
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
WBPaper00042477:prp-8(RNAi)_upregulated_RNAseq
WBPaper00042477:rsr-2(RNAi)_upregulated_RNAseq
WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray
WBPaper00042561:smg-2(RNAi)_upregulated
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00044037:eat-2_downregulated
WBPaper00044316:CH3HgCl_2.0uM_upregulated
WBPaper00044316:CH3HgCl_7.5uM_upregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00045390:ubc-9(RNAi)_upregulated
WBPaper00045401:N.parisii_40h_upregulated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045774:clk-1_upregulated
WBPaper00046012:tdp-1(ok803)_upregulated
WBPaper00046415:lithium_downregulated
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048923:Aging_regulated
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049905:Age_variant_expression
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050080:rbr-2(tm3141)_downregulated
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050504:hrp-2(RNAi)_upregulated
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
WBPaper00053664:ins-11(tm1053)_downregulated
WBPaper00053771:up_at_3h-NaCl
WBPaper00053771:up_at_24h-NaCl
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00054410:set-9(rw5)_upregulated
WBPaper00054410:set-26(tm2467)_upregulated
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055013:hmg-3(bar24)_upregulated
WBPaper00055013:spt-16(RNAi)_upregulated
WBPaper00055060:flr-1(RNAi)_downregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:eat-2(ad465)_upregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055941:atfs-1(et15)_downregulated
WBPaper00055941:atfs-1(gk3094)_upregulated
WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
WBPaper00055941:nuo-6(qm200)_upregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056034:pals-25(jy9)_upregulated
WBPaper00056167:Cry5B_downregulated
WBPaper00056167:ifo-1(kc2)_downregulated
WBPaper00056169:rrf-3(pk1426)_downregulated_L1
WBPaper00056169:rrf-3(pk1426)_downregulated_L2
WBPaper00056169:rrf-3(pk1426)_downregulated_L3
WBPaper00056169:rrf-3(pk1426)_downregulated_L4
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056293:rpl-5(0)-rpl-33(0)_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056617:adr-2_upregulated_embryo_transcript
WBPaper00056809:smn-1(ok355)_upregulated
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057068:Cadmium_upregulated
WBPaper00057068:ints-4(RNAi)_upregulated
WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
WBPaper00057068:numr-1(RNAi)_downregulated
WBPaper00057196:raga-1(ok386)_upregulated)
WBPaper00057265:metaformin_downregulated_OP50
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058711:wdr-5(ok1417)_upregulated
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00058725:sftb-1(cer39)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00059117:B.subtilis_downregulated
WBPaper00059191:hsp-16.2p-LIN-29_downregulated
WBPaper00059334:sacy-1(depletion)_regulated
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059605:mut-16(pk710)_upregulated
WBPaper00059739:hira-1(gk835598)_upregulated_L4
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
WBPaper00060661:sensory-neuron_enriched
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061527:C10C5.2-Y58A7A.3
WBPaper00061530:nhr-49(e2144)_downregulated
WBPaper00061692:acivicin_upregulated
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00061995:mter-4(syb3662syb3403)_upregulated
WBPaper00062103:neuron_enriched
WBPaper00062118:neural-HSF-1_downregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:daf-16(RNAi)_upregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062345:bortezomib_4h_upregulated_N2
WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062590:Aging_upregulated_intestine
WBPaper00062669:extracellular-vesicle_protein
WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
WBPaper00062672:let-418(n3536)_upregulated
WBPaper00064005:starvation_downregulated_N2_mRNA
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064107:lin-35(n745)_upregulated
WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
WBPaper00064375:sid-1(pk3321)_regulated
WBPaper00064532:pals-22(jy3)_upregulated
WBPaper00064539:nhr-114(gk849)_upregulated
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064727:daf-2(e1370)_downregulated
WBPaper00064769:him-17(me24)_upregulated
WBPaper00064841:tent-5(tm3504)_upregulated_transcript
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00065005:sams-4(RNAi)_upregulated
WBPaper00065029:cadmium_upregulated
WBPaper00065074:glna(-)_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065749:Heat-Shock-With-Recovery_upregulated_endu-2(tm4977)
WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
WBPaper00065841:1_0
WBPaper00065841:13_1
WBPaper00065841:57_0
WBPaper00065841:57_1
WBPaper00065841:115_0
WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
WBPaper00065945:epidermis-rpoa-2(-)_upregulated_transcript
WBPaper00065945:global-rpoa-2(-)_upregulated_transcript
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066004:tdp-1(csb38)_upregulated
WBPaper00066005:RAGA-1_degradation_somatic_downregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066204:CdCl2_upregulated_mRNA
cgc4489_group_9
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026952:class_B
WBPaper00027111:eri-1(mg366)_upregulated
WBPaper00027111:rde-3(ne298)_upregulated
WBPaper00027111:rde-3(r459)_upregulated
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00032165:differentially_expressed_with_age_medoid_2
WBPaper00035429:UVC_upregulated
WBPaper00036123:Atrazine_regulated
WBPaper00036130:mir-243_up_regulated
WBPaper00036286:Pattern_D
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_aging
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_old
WBPaper00040858:eQTL_regulated_reproductive
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HF_11d_0.2mM_Up
WBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00047070:DAF-16-dependent_UV_response
WBPaper00047070:N2_UV_upregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00055899:nitroguanidine_regulated
WBPaper00056330:mrps-5(RNAi)_upregulated
Interaction (133)
Map_info (3)
ReferenceWBPaper00006402
WBPaper00006421
WBPaper00028970
WBPaper00031023
WBPaper00035429
WBPaper00038491
WBPaper00046184
WBPaper00055090
WBPaper00062515
WBPaper00064375
RemarkSequence connection from [Sheps JA, Baillie DL] [040902 ck1]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene