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WormBase Tree Display for Gene: WBGene00003969

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Name Class

WBGene00003969SMapS_parentSequenceF23H11
IdentityVersion1
NameCGC_namepef-1
Sequence_nameF23H11.8
Molecular_nameF23H11.8a
F23H11.8a.1
CE27999
F23H11.8b
CE30662
F23H11.8c
CE43732
F23H11.8b.1
F23H11.8b.2
F23H11.8c.1
Other_nameCELE_F23H11.8Accession_evidenceNDBBX284603
Public_namepef-1
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpef
Allele (265)
StrainWBStrain00032302
WBStrain00047611
RNASeq_FPKM (74)
GO_annotation (24)
Contained_in_operonCEOP3805
Ortholog (42)
Paralog (44)
Structured_descriptionConcise_descriptionpef-1 encodes an ortholog of the rhodopsin-specific serine/threonine phosphatase RdgC in D. melanogaster and of RdgC-related proteins in humans (PPEF1 and PPEF2; OMIM:300109 and OMIM:602256); PEF-1 has a EF-hand calcium-binding domain, and is peripherally bound to the plasma membrane by myristoylation and palmitoylation; pef-1 has no known mutant phenotype, but is expressed in several anterior amphid neurons, from what appears to be the 3-fold embryo stage onward; on the basis of its expression and its orthology, PEF-1 may negatively regulate signalling through serpentine receptors such as STR-2.Paper_evidenceWBPaper00004766
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in detection of stimulus involved in sensory perception. Located in neuronal cell body. Expressed in hypodermis; intestinal cell; muscle cell; and neurons. Is an ortholog of human PPEF1 (protein phosphatase with EF-hand domain 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_info (4)
Experimental_infoRNAi_resultWBRNAi00045447Inferred_automaticallyRNAi_primary
WBRNAi00006514Inferred_automaticallyRNAi_primary
WBRNAi00115957Inferred_automaticallyRNAi_primary
WBRNAi00013834Inferred_automaticallyRNAi_primary
Expr_patternExpr1500
Expr2115
Expr1020293
Expr1031893
Expr1149366
Expr2014817
Expr2033051
Drives_constructWBCnstr00010314
WBCnstr00035766
Construct_productWBCnstr00035766
AntibodyWBAntibody00000387
Microarray_results (25)
Expression_clusterWBPaper00033065:clk-1(qm30)_upregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037682:sma-2_sma-4_upregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:excretory-cell_larva_enriched
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040209:B.thuringiensis_downregulated_MY15
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00042561:smgl-2(RNAi)_upregulated
WBPaper00044037:eat-2_regulated_nhr-62_dependent
WBPaper00044037:eat-2_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00045774:clk-1_upregulated
WBPaper00045934:wrn-1(gk99)_downregulated
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049942:HeatShock_downregulated_hsf-1(+)
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050344:ASER-neuron_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:intestine_expressed
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053388:dauer_regulated_Cluster4
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055827:daf-2(e1370)_upregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056826:hmc_biased
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058725:sftb-1(cer6)_upregulated
WBPaper00058725:sftb-1(cer39)_downregulated
WBPaper00058725:sftb-1(cer39)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00059027:neuron-synapses_depleted
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059728:5ug_cholesterol_upregulated
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059987:Wounding_upregulated
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:AWC
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061527:T16H12.9-kin-9_20752
WBPaper00061651:AFD_enriched
WBPaper00061651:BAG_enriched
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064502:spe-44(fx110)_downregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064769:him-17(me24)_upregulated
WBPaper00064871:hypoxia_downregulated_F1
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065749:Heat-Shock_downregulated_N2
WBPaper00065835:Day5_vs_Day1_downregulated
WBPaper00065841:4_0
WBPaper00065841:23_0
WBPaper00065841:35_0
WBPaper00065841:35_1
WBPaper00065841:35_2
WBPaper00065841:35_3
WBPaper00065841:35_4
WBPaper00065841:85_0
WBPaper00065841:102_0
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
cgc4489_group_15
WBPaper00024671:AFD_vs_AWB_upregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Enriched_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030839:Embryo_A_Class
WBPaper00031003:0hr_muscle_enriched
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_enriched
WBPaper00032948:StarveUp2
WBPaper00035588:alg-1(-)_upregulated
WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00045673:colistin_upregulated
WBPaper00047070:N2_starvation_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00057098:SiO2-nanoparticles_upregulated
Interaction (17)
Map_infoMapIIIPosition-25.0941Error0.017637
PositivePositive_cloneF23H11Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5654
Pseudo_map_position
ReferenceWBPaper00004766
WBPaper00038491
WBPaper00055090
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene